Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0345904 (
liver cancer
)
15,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Alternative splicing within a gene can create different versions of an mRNA, called isoforms. CFIm, composed of a small subunit CFIm25 and two large subunits CFIm68 and CFIm59 (also known as
CPSF7
), has been proposed as an enhancer-dependent activator of mRNA 3' processing. In this study, we investigated the role of
CPSF7
in hepatocellular carcinoma. Experimental evidence suggests that the expression level of
CPSF7
is higher in
liver cancer
cells and tissues than in non-tumor hepatic cells and tissues. Furthermore, knockdown of
CPSF7
effectively suppressed cell proliferation, migration and colony formation in
liver cancer
cells by inhibiting PTEN/AKT signaling.
CPSF7
promoted WWP2-FL due to the presence of PTEN ubiquitination sites in this longer transcript. Taken together, we identified that
CPSF7
regulates
liver cancer
growth by targeting WWP2-FL that in turn regulates AKT activation in a PTEN-dependent manner.
...
PMID:CPSF7 regulates liver cancer growth and metastasis by facilitating WWP2-FL and targeting the WWP2/PTEN/AKT signaling pathway. 3183 82
