Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0345904 (
liver cancer
)
15,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The present study aimed to investigate the role of
caprin-1
in
liver cancer
and its association with the clinicopathological features and prognosis of
liver cancer
, as well as the underlying mechanism of
caprin-1
function.
Caprin-1
expression levels in a tissue microarray containing 40
liver cancer
tissues, 10 peritumoral tissues and 20 normal liver tissues were analyzed using immunohistochemistry. The clinical data of 154 patients with
liver cancer
were also collected from The Cancer Genome Atlas database. Kaplan-Meier analysis and a Cox proportional hazards regression model were used to assess the association between
caprin-1
expression levels and survival in patients with
liver cancer
. The effects of
caprin-1
knockdown on the mRNA levels of cyclin D1 and cyclin D2 as well as the proliferation, invasion and migration of HepG2 cells were also investigated. The expression level of
caprin-1
in
liver cancer
tissues was significantly higher compared with normal liver tissues or cells (P<0.01). High
caprin-1
expression levels were associated with advanced clinical stage (P<0.001) and enhanced tumor invasion (P<0.001). Kaplan-Meier analysis showed that the overall survival time and disease-free survival time in patients with
liver cancer
with high
caprin-1
expression were significantly shorter compared with patients with low
caprin-1
expression levels (P=0.002 and P=0.033, respectively). The Cox proportional hazards regression model showed that high
caprin-1
expression levels were an independent prognostic factor for
liver cancer
(P<0.001). Knockdown of
caprin-1
in HepG2 cells significantly downregulated mRNA expression levels of cyclin D1 and cyclin D2, inhibited cell proliferation and invasion and the cells were arrested at G
0
/G
1
phase. In conclusion,
caprin-1
may be a novel prognostic indicator for patients with
liver cancer
.
...
PMID:Caprin-1 promotes HepG2 cell proliferation, invasion and migration and is associated with poor prognosis in patients with liver cancer. 3272 19
