Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Lens culimaris agglutinin A-reactive alpha-fetoprotein (AFP L3) and erythroagglutinating phytohemagglutin-reactive alpha-fetoprotein (AFP P4 + P5) were determined by a sensitive method using lectin-affinity electrophoresis coupled with antibody-affinity blotting, and the usefulness of this method for early detection of hepatocellular carcinoma (HCC) was examined. For 72 operated cases of the HCC group including 28 cases of small liver cancer, the AFP value was 124 +/- 198ng/ml (Mean +/- SD); the lectin fraction values for L3 and P4 + P5 were 12.2 +/- 17.9 and 17.9 +/- 17.9%, respectively, which were significantly higher compared with the chronic hepatitis (CH).cirrhosis (LC) group and showed an increasing tendency with an increase in tumor diameter. The cut-off values for distinguishing HCC from CH.LC, determined with the receiver-operating characteristic (ROC) plots, were 10.0 and 15.0% for the L3 and P4 + P5 fractions, respectively, and the positive rates in the patient with HCC were 33.3 and 48.6% for AFP L3 and AFP P4 + P5, respectively, and 59.7% with a combination assay. For small liver cancer, the positive rate was 17.9% with protein induced by vitamin K absence-II (PIVKA-II) and 46.4% with combination assay of AFP L3 and AFP P4 + P5. Also, for HCC below AFP 50ng/ml, a positive rate of 45.0% was obtained. In the CH.LC group, all cases were negative for AFP L3 and 2 of 44 cases (4.5%) were false-positive for AFP P4 + P5.
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PMID:[Early detection of hepatocellular carcinoma with lectin reactive alpha-fetoprotein]. 752 71

Our patient presented with a large liver mass, an extremely elevated AFP level, and an almost certain diagnosis of HCC. However, extensive evaluation and biopsies failed to demonstrate malignancy, and the available evidence strongly suggests that the patient has an adult polycystic disease without renal involvement, and that the mass was the result of hemorrhage and degenerative changes in one of his cysts. Polycystic diseases can involve only one lobe, as it appears in this case. Only about 10-15% of patients with polycystic disease have symptoms due to the liver disease, while 30-50% have associated renal disease. Thus, our patient is unusual in several respects. However, his liver mass has decreased in size, he feels well, and his biochemical abnormalities have returned to normal. Despite a classic presentation for HCC, this case underscores the necessity for a thorough evaluation, especially for patients without major risk factors for hepatocellular carcinoma.
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PMID:A 22-year-old man with a liver mass and markedly elevated serum alpha fetoprotein. 753 71

Case 1 was a 55-year-old male with multiple pulmonary metastases after two operations to excise hepatocellular carcinoma. Treatment consisted of initial administration of 5'-DFUR (po), followed by frequent administration of low-dose epirubicin (20 mg/body once every 2 weeks iv). This resulted in disappearance of the pulmonary metastases and a striking decrease in the AFP level. Case 2 was a 68-year-old male with multiple pulmonary metastases after surgery for hepatocellular carcinoma. Treatment with 5-FU (iv; once a week) and epirubicin (20 mg/body once every 2 weeks iv) resulted in disappearance of the pulmonary metastases and a marked decrease in the AFP level. It was concluded that administration of epirubicin in frequent, low doses is a useful method for the treatment of pulmonary metastasis after surgery for liver cancer, and it can be safely performed even on an outpatient basis.
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PMID:[Efficacy of treatment with frequent and low-dose epirubicin in two cases of pulmonary metastases after surgery of liver cancer]. 757 17

Hepatic resection had been performed in 600 cases with primary liver cancer (PLC) in our hospital from 1964 to 1993. Among them, 24 cases underwent second hepatic resection because of tumor reccurrence. The ratio of male to female was 8.0:1. Most of the patients were 40 to 59 years old. and the age ranged from 8 to 78 years old. The positive rate of AFP was 57.4% (> 400 micrograms/L). of them, 84.4% were associated with hepatic cirrhosis. Hepatocellular carcinoma was verified in 91.6% of these cases. Small tumor (< 5cm in diameter) was found in 130 cases (21.7%). In this series, 10 cases underwent semi-hepatectomy and 590 cases underwent irregular hepatectomy. Spontaneous rupture of tumor was found in 29 cases. In 13 of 600 cases, hepatectomy was done after transcatheter hepatic arterial chemoembolization. Six of 600 cases underwent second stage hepatectomy because the tumots could not be resected during laparotomy. After multimodality therapy, including tumor ethanol injection treatment, microwave tumor coagulation and hepatic artery chemoembolization, the tumors became small and subsequently resected. In these 600 cases, 24 cases died within one month after hepatectomy with a mortality of 4.0%. The most common cause of death was hepatic failure. The 1-,3-,5-, 10-year survival rates were 61.9%, 40.2%, 33.0%, 29.2%, respectively in the whole series and 87.8%, 69.4%, 54.0%, 43.0% respectively in patients with small tumor.
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PMID:[Results of hepatic resection for 600 cases with primary liver cancer]. 765 3

Intra-arterial CDDP-Lipiodol infusion chemotherapy using an implantable port was effective in 10 unresectable liver cancer patients, including 7 hepatocellular and 3 metastatic cases. CDDP-Lipiodol suspension (10 mg of CDDP/1 ml of Lipiodol) was administered at the dose of 25 mg/m2 of CDDP biweekly from 2 to 9 times. The clinical responses were defined as 4 PR (40%), 5 NC (50%), including 3 MR, and 1 PD (10%). The efficacy rate was 40%. The level of AFP and CEA was reduced in all PR and NC cases except one. Side effects were nausea (70%), low-grade pyrexia (50%), abdominal pain (30%), and liver dysfunction (20%), but they were tolerable and transient.
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PMID:[Intra-arterial infusion chemotherapy of cisplatin (CDDP)-lipiodol suspension using implantable injection port for unresectable liver cancer patients]. 769 May 35

Of 275 patients who had a radical hepatic resection for HCC, 143 (52%) experienced recurrences. Of these 143 patients, the liver was the site of first recurrence in 130 patients (91%). The first form of therapy for recurrent patients was transarterial chemoembolization (TACE) in 82 (74%), hepatic resection in 15 (14%) and percutaneous ethanol injection in 6 (5%) of the 111 patients who received regional therapy. Post-recurrent survival rates of TACE and hepatic resection were 37%, 77% at 3 years and 17%, 77% at 5 years, respectively. Wrapping therapy was performed in seven patients, two of whom had received repeat TACE for intrahepatic recurrence; the remaining 5 were unresectable cases. After wrapping therapy, the area of previous collateral feeders was be supplied by the hepatic artery. The high level of AFP decreased dramatically. This procedure resulted in a complete response in 2 patients, a partial response in 3 and no change in 2. Overall survival was 4-54 months, and the median survival was 18 months. Two patients are still alive, 18 and 20 months after the procedure.
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PMID:Palliative surgical treatment for recurrent and non-resectable hepatocellular carcinoma. 769

We reported a case in which 99mTc-PMT scintigraphy was useful in diagnosing orbital metastasis of HCC. The case involved a 70 y.o. male, who had undergone nine transcatheter arterial embolizations over two years because of HCC and who had a past history of gastric cancer. The patient had complained of headache and visual disturbance for two months. Cranial CT and MRI studies showed a large homogeneous mass with remarkable bone destruction in the right lateral orbital wall. Because AFP was elevated, orbital metastasis of HCC was suspected, and 99mTc-PMT scanning was performed. On the planar and SPECT images, very high uptake was found in the right orbital tumor. The FDG-PET study showed remarkable hypermetabolism in the medial portion of tumor and follow-up MRI revealed that the tumor had expanded and invaded to the medial side of the orbit. 99mTc-PMT scanning was critical in diagnosing this case of orbital metastasis, and FDG-PET imaging was useful in determining the most active portion of the tumor.
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PMID:[Usefulness of 99mTc-PMT SPECT and 18F-FDG PET in diagnosing orbital metastasis of hepatocellular carcinoma]. 780 27

By a modified serum 64-DP isolation method we successfully isolated alpha-DNA binding protein (alpha DBP) to electrophoretic purity. Analysis by SDS-PAGE revealed a molecular weight of 59,000. It suggested that alpha DBP is a glycoprotein. Goat anti-alpha DBP anti-serum was prepared and single radial immunodiffusion assay was used to screen 256 healthy individuals (teachers, students, workers and peasants) and serum samples from 969 patients with various kinds of cancers. Contrary to previous findings, we found that serum alpha DBP was abundant in healthy individuals with homogeneous precipitation rings, and was not significantly increased in the serum of cancer patients. However, it depicted a heterogeneous pattern with 1-4 rings of various thickness. This phenomenon was observed in 94.2% of patients with liver cancer regardless of the presence or absence of AFP. We would suggest that the change of alpha DBP band from homogeneity to heterogeneity may be a sign of carcinogenesis in the body.
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PMID:[Different manifestation of DNA binding protein in healthy individuals and cancer patients]. 803 42

Epidemiological, clinical, biochemical and topographic features of primary hepatic cancer (PHC) were reviewed retrospective and prospectively in this study. This review consisted of 76 patients from 1971 to 1990. Forty nine males and 27 females. The mean age was 66.1 +/- 11.7 years. Hepatocellular carcinoma (HC) was the most frequent histological type (84.1%), followed by cholangiocarcinoma (87.7%). Mixed carcinoma and hepatoblastoma were 4.3 and 2.9% respectively. The prevalence af PHC among 1485 autopsies was 0.74%. The most frequent sites af metastasis were the lungs (66%) and portal vein (50%). Hepatocellular carcinoma was associated to cirrhosis in 80% of the cases. A syndrome including asthenia, weight loss, hepatomegaly and cholestasis was identified in most of the patients, and alkaline phosphatase was the most frequently disturbed laboratory test. 60% of tumors were bilateral and none of the solitary tumors had less than 5 cms in diameter. 20% of HC showed normal serum levels of AFP (< 20 ng/ml). 40% had at least one of the markers of B virus hepatitis in serum.
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PMID:[Primary liver cancer. Its epidemiological, clinical and biochemical characteristics]. 820 48

There has not been reported that DNA ploidy status of hepatocellular carcinoma may be used to predict the prognosis of patients with large liver cancer treated with radiotherapy combined with Chinese traditional medicine. In this series, the ploidy of DNA pattern in 28 cases were analyzed. Of them, the diploid accounts for 57.14% and aneuploid for 42.86%. Correlative analysis indicated that the clinical course of the disease in diploid cases was less severe than those in aneuploid ones (P < 0.05) and the response to treatment of patients with diploid DNA pattern was better than that of aneuploid ones (P < 0.01). However, there was no significant correlation between ploidy of DNA pattern and tumor size, AFP level or degree of differentiation of cancer cells (P > 0.05), which indicated that the ploidy pattern may be of significance in the treatment outcome of large liver cancer by radiotherapy.
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PMID:[Clinical significance of tumor cell DNA analysis in patients with large hepatocellular carcinoma treated with irradiation combined with traditional Chinese medicine]. 839 29


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