Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 306 individuals from South Vietnam were studied: 61 had a diagnosis of primary liver cancer (38 had a tissue diagnosis, and 23 had a clinical diagnosis and a positive alpha-fetoprotein); 9 had viral hepatitis; 101 were hospitalized patients (60 with various other forms of liver disease and 41 without liver disease); 94 were blood donors; 29 were drug users, and 12 were medical students. Alpha-fetoprotein was present in 45 of 61 (74%) of those with a diagnois of primary liver cancer (PLC) and in none of the other patients. Using immunoelectroosmophoresis, hepatitis BS antigen (HBSAg) was found no more frequently in those with PLC than in the other groups studied. In contrast, using a radioimmunoassay technique HBSAg was present 3 to 8 times as frequently in the PLC patients as in other subjects without viral hepatitis. There was a close relationship between the presence of alpha-fetoprotein and HBSAg in the patients with PLC. Malaria seropositivity rates were no different in the PLC groups than the other groups. It appears that in South Vietnam PLC is associated with an increased frequency of HBSAg.
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PMID:Hepatitis BS antigen, malaria titers, and primary liver cancer in South Vietnam. 5 72

A case/control study has been carried out to determine the prevalence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs) in patients with primary liver cancer (PLC), and age/sex matched hospital controls with cancers of other sites (OCC) and similarly matched controls without cancer (NCC). HBsAg was found in 61.2% of 165 cases of PLC, as compared to 11.7% of 154 OCC and 11.3% of 328 NCC. The frequency of HBsAg in PLC patients was significantly higher (72.2%) in those with detectable alpha-fetoprotein as compared to those without (40.3%).
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PMID:[Primary liver cancer and hepatitis B infection in Senegal. Comparison of cancer patients with 2 control groups]. 6 Jan 44

A new method, radio-crossed immunoelectrophoresis, demonstrates alpha-fetoprotein (AFP) in sera with a sensitivity of 1 mug/1. By this method AFP with alpha mobility was not found in sera from healthy individuals, patients with chronic active hepatitis and cirrhosis, primary biliary cirrhosis, secondary liver cancer and cystic fibrosis. In some of the sera, AFP was elevated when measured by conventional radioimmunoassay method and the sera contained an AFP-like substance with gamma mobility when analyzed by radio-crossed immunoelectrophoresis. The nature of this gamma substance is still obscure and needs further investigation.
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PMID:Alpha-fetoprotein-like activity in sera from patients with malignant and non-malignant disease and healthy individuals. 6 Oct 78

Three of 42 (7%) monkeys given aflatoxin B1 (AFB1) for longer than 2 years have developed primary malignant neoplasms of the liver. Liver biopsies performed at intervals during aflatoxin administration revealed that neoplasia was preceded by pathologic lesions of the liver, including toxic hepatitis, proliferation of pseudotubules, and hyperplastic nodules. Serum alpha-fetoprotein levels, monitored in one of the monkeys by radioimmunoassay, paralleled tumor growth and recurrence of the hepatocellular carcinoma. Normal serum alpha-fetoprotein levels were noted for a monkey with hemangioendothelial sarcoma. Our results implicate AFB1 as a liver carcinogen in monkeys and add additional support to the hypothesis that humans exposed to this substance may be at risk of developing liver cancer.
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PMID:Carcinogenicity of aflatoxin B1 in rhesus monkeys: two additional cases of primary liver cancer. 6 57

In a study of the association between circulating alpha-fetoprotein concentrations and spontaneous hepatocellular carcinomas, we examined C3H-Avy fB mice, which with age consistently demonstrate a rapidly increasing incidence of hepatic cancer. Although elevated alpha-fetoprotein levels are observed in association with the majority of these tumors, no elevation of alpha-fetoprotein was observed during the life course of non-tumor-bearing mice despite their age-dependent risk for hepatic cancer. Therefore, whatever the evolutionary or age-related biological changes may be that lead to tumor formation in this mouse, they are not linked to the synthesis of significant amounts of this oncofetal protein.
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PMID:Serum alpha-fetoprotein in a mouse strain (C3H-Avy fB) with spontaneous hepatocellular carcinomas. 6 18

The presence in the serum of alpha-1-fetoprotein (AFP) was studied by the following immunological methods: immunoprecipitation electrophoresis after Pesendorfer et al., modified micro Ouchterlony technique as described by Prince, and for quantitative determination of this fraction commercial Partigen plates with sensitivity above 1 mg/100 ml. were used (Behringwerke A.G.). Anti AFP serum produced by the same company was used. In our experiance these three methods were equally sensitive In the newborn (41) with hyperbilirubinemia (cytomegalic inclusion disease, toxoplasmosis, ABO and Rh incompatibility) despite persisting abnormal laboratory tests indicating liver damage AFP disappeared from circulation by the end of the first month. Fetoprotein has been demonstrated in the serum by the end of the third month in nine babies in whom malformation of the biliary ducts was confirmed intraoperatively (7,14). In adults AFP was observed in the serum of only those patients in whom presence of primary hepatocellular liver cancer was proved pathohistologically Out of 15 verified cases of primary liver cancer AFP was positive in 43.7%.
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PMID:Diagnostic significance of alpha-fetoproteins in neonatal hyperbilirubinaemias and primary cancer of the liver in adults. 6 34

The present paper describes the present status of clinical tests for cancer in Japan. Since no cancer-specific substance has been found so far the clinical tests for cancer at present are always quantitative but not qualitative. Among these substances, alpha-fetoprotein is one of the most specific substances for cancer and its test is essential for diagnosis of hepatoma beins used worldwide. AFP is a specific product of liver cancer cells. The measurement of carcinoembryonic antigen in patient blood is a hopeful method for cancer diagnosis. This substance is not specifically produced by cancer cells, but the phenomenon of appearance in bloodstream appears to be cancer-specific. This may reflect the invasion of blood vessels in tissues such as colorectum, lung, etc., by infiltration of cancer cell. This is the reason for the appearance of CEA in a wide variety of cancers. There are many other clinical tests at present but these are only secondary aids for the diagnosis of cancer. This is the reason why the description concentrates mostly on AFP and CEA. The companies manufacturing the kits for these tests in Japan are also listed in this paper.
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PMID:The development of laboratory tests for cancer in Japan with special reference to carcinoembryonic proteins. 7 74

Seventy-one patients with liver cancer were examined by B-scan ultrasonography. The presence of liver cancer was assumed through the irregularity and increased intensity of echos. The accuracy of ultrasonography in the diagnosis of liver cancer was 72%, while the diagnostic accuracy of scintigraphy was 85% and angiography 93%. No obvious correlation could be demonstrated between the ultrasonographic patterns and serum alpha-fetoprotein (AFP) levels. Ultrasonography is a useful method of detecting liver cancer.
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PMID:Value of B-scan ultrasonography in the diagnosis of liver cancer. Accuracy compared to scintigraphy and angiography. 8 Jan 30

A short review of alpha-1-fetoprotein (AFP), is followed by a presentation of the serum AFP concentrations obtained in healthy subjects and in patients with hepatoma, cirrhosis of the liver or metastatic liver cancer, measured by radioimmunoassay (RIA). A calculation is made from these results of the upper limit of normal (9 ng/ml), a limit which is suggestive of hepatoma (215 ng/ml) and a limit which is pathognomonic for hepatoma (7500 ng/ml). It is concluded that the quantitative determination of AFP by RIA represents a sensitive method which provides valuable clinical information for the early diagnosis of hepatoma.
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PMID:[Serum concentrations of alpha-1-fetoprotein suggestive of, or pathognomonic for hepatoma (author's transl)]. 8 72

Vitamin A level and the cytosol-binding proteins specific for vitamin A ere studied in human tumor and its surrounding tissue. The tissues examined were 10 hepatocellular carcinomas which were surgically removed, 4 other malignant tumors (2 metastatic liver cancer and one each of gastric cancer and glioma), and 3 human fetal livers. Compared with surrounding tissues, considerable decrease of vitamin A content was observed in the hepatocellular carcinoma suggesting local deficient state of the vitamin. In addition to cellular retinol-binding protein (CRBP) and retinoic acid-binding protein (CRABP), a new molecular species having affinity for both retinol and retinoic acid was detected in the cytosols obtained from hepatocellular carcinoma as well as glioma by means of gel filtration on Sephadex G-75. With regard to ligand specificity, the protein was found to be similar to cellular retinol-binding protein, F-type or CRBP(F) which was originally recognized in the fish eye cytosol. Since the protein was also demonstrated in human fetal liver, CRBP(F) is considered to be an oncofetal protein in nature. The present study further revealed that CRBP(F) was detected in 80% of hepatocellular carcinoma (whereas plasma alpha-fetoprotein was significantly elevated only in 50%), and hepatocellular carcinoma contained CRBP(F) in a larger amount than CRABP.
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PMID:Demonstration of a novel cellular retinol-binding protein, F-type, in hepatocellular carcinoma. 8 58


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