Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0345904 (
liver cancer
)
15,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Phosphoglycerate kinase 1
(
PGK1
) is an important enzyme in the metabolic glycolysis pathway. In this study, we observed a significant overexpression of
PGK1
in
liver cancer
tissues and a negative correlation between
PGK1
expression and
liver cancer
patient survival. Furthermore, depletion of
PGK1
dramatically reduced cancer cell proliferation and tumorigenesis, indicating an oncogenic role of
PGK1
in
liver cancer
progression. Moreover, we identified acetylation at the K323 site of
PGK1
as an important regulatory mechanism for promoting its enzymatic activity and cancer cell metabolism. And we further characterized P300/cyclic adenosine monophosphate response element binding protein-binding protein-associated factor (PCAF) and Sirtuin 7 as the enzymes regulating K323 acetylation from both directions in
liver cancer
cells.
...
PMID:Acetylation of PGK1 promotes liver cancer cell proliferation and tumorigenesis. 2880 69
