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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this paper, laser induced human serum Raman spectra of liver cancer are measured. The spectra in serum differences between normal people and liver cancer patients are analyzed. For the typical spectrum of normal serum, there are three sharp Raman peaks and relative intensity of Raman peaks excited by 514.5 nm is higher than that excited by 488.0 nm. However, for the Raman spectrum of liver cancer serum there are no peaks or very weak Raman peaks at the same positions. To liver cirrhosis, the shape of Raman peak is similar to normal and fluorescence spectrum is similar to that of liver cancer from statistic data. The results from more than two hundred case measurements show that the spectral diagnosis was in good agreement with the clinical result. Moreover, the liver fibrosis and liver cirrhosis were studied using the technology of LIF. The experiment indicates that the blue shift of fluorescence peak difference between the normal, liver fibrosis and liver cirrhosis were observed. These results have important reference values to explore the method of laser spectrum diagnosis.
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PMID:Raman spectroscopy and fluorescence for the detection of liver cancer and abnormal liver tissue. 1727 47

induced fluorescence(LIF) and Raman spectra were measured from normal and tumorous human serum in an attempt to discover some values useful in discrimination between normal and tumorous cases. Red shift of fluorescence peak and decrease of fluorescence intensity were observed after samples radiated by laser. According to one thousand twenty-two samples' spectra, three parameters α, β and δγ are introduced to distinguish normal, benign and malignant from one another. The application of such parameters in clinical diagnosis was researched. The practical instrument of laser-induced serum fluorescence and resonance Raman spectra for cancer diagnosis or incipient cancer is designed, by combining laser spectroscopy, biomedical, photo-electron technology, controlling technology and computer technology. The instrument is intelligent for operating and diagnosing. The clinic application of this instrument has been carried out successfully in the diagnosing of stomach cancer and liver cancer (459 cases); the accuracy is about 85%. It develops a new technology in the field of cancer diagnosis.
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PMID:Study of method and system for diagnosis of cancer using autofluorescence and Raman spectroscopy. 1728 87

Suppressor of cytokine signaling (SOCS) is a new family of proteins produced in cells. It may play an important role in classic negative feedback loop to regulate cytokine signal transduction. SOCS-1 was observed and confirmed firstly. Expression of SOCS-1 can inhibit cytokine signal transduction of some cytokines, such as IL-6, LIF, OSM, INF-gamma, GH, and so on, many immune responses are regulated by them in vivo. Abnormal expression of SOCS-1 is closely related to some human diseases. It plays an important role in the development of leukemia, rheumatoid arthritis, liver cirrhosis and liver cancer. In this review, the advances of research on the relationship between SOCS-1 and cytokine, and its correlation with some diseases were summarized.
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PMID:[Progress of study on suppressor of cytokine signaling-1 - review]. 1749 65

A rapid and highly sensitive CE immunoassay method integrating mixing, reaction, separation, and detection on-chip is described for the measurement of alpha-fetoprotein (AFP), a liver cancer marker in blood. Antibody-binding reagents, consisting of 245-bp DNA coupled anti-AFP WA1 antibody (DNA-WA1) and HiLyte dye-labeled anti-AFP WA2 antibody (HiLyte-WA2), and AFP-containing sample were filled into adjacent zones of a chip channel defined by the laminar flow lines of the microfluidic device using pressure-driven flow. The channel geometry was thus used to quantitatively aliquot the reagents and sample into the chip. DNA-WA1 was electrokinetically concentrated in the channel and sequentially transported through the AFP-sample zone and HiLyte-WA2 zone by ITP in such a manner that the AFP sandwich immune complex formation took place in the sample and HiLyte-WA2 zones. The sandwich AFP immune complex was then detected by LIF after CGE in a separation channel that was arranged downstream of the reaction channel. AFP was detected within 136 s with a detection sensitivity of 5 pM. The on-chip immunoassay described here, applying ITP concentration, in-channel reaction, and CGE separation, has the potential of providing a rapid and sensitive method for both clinical and research applications.
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PMID:Electrokinetic analyte transport assay for alpha-fetoprotein immunoassay integrates mixing, reaction and separation on-chip. 1838 19