Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mortalities from cancer and other causes among Koreans living in Fukuoka, Japan, between 1976 and 1986 were examined as compared with those of Japanese in the prefecture. Korean males had a marked excess in all-cause mortality, while the excess among females was less prominent. In both sexes, mortalities from liver cancer, liver cirrhosis, accident and suicide were markedly increased in the Korean population. These findings are in agreement with those observed among Koreans in Osaka. Although 20-30% lower-than-Japanese mortality from stomach cancer has been reported for Koreans in Osaka, those in Fukuoka had a risk of this cancer comparable to that of Japanese. A life-style survey of Koreans in Japan might provide a better understanding of the disease patterns observed in this population.
Jpn J Cancer Res 1990 Sep
PMID:Cancer and other causes of death among Koreans in Fukuoka, Japan, 1976-1986. 212 87

Between January 1982 and April 1989, 134 patients with a suspected liver neoplasm were referred to the liver unit, Queen Elizabeth Hospital, Birmingham. In 105 (78 per cent), a primary hepatic neoplasm was histologically confirmed, and 47 patients (45 per cent) proved to have primary hepatocellular carcinoma. Twenty-nine orthotopic liver transplants were performed in 28 of these patients (27 per cent). Twenty patients (71 per cent) survived 30 days or longer (median 11.5 months; range 2-87 months), of whom nine are currently alive. We retrospectively analysed our data to determine the influence of preoperative evaluation, histological type and staging on outcome. Computed tomography proved to be superior to intraoperative assessment (86 versus 58 per cent) in diagnosing tumour positive nodes. Patients with tumour negative lymphadenopathy had a better prognosis. Postoperative stage I/II had a median survival of 16 months (range 3-87 months) compared with 7.5 months (range 2-20 months) for stage III. Non-cirrhotic patients with hepatocellular carcinoma had the best prognosis; cholangiocellular carcinoma and cirrhotic patients with hepatocelluar carcinoma had the worst outcome with no survivors beyond 1 year. Because of the advanced stage of disease at the time of presentation, the value of liver transplantation in primary liver cancer is limited. For those presenting with advanced disease confined to the liver (stage I/II) in whom conventional hepatic resection is not possible, significant benefit can be achieved in selected cases.
Br J Surg 1990 Sep
PMID:Primary hepatic malignancy: the role of liver transplantation. 216 46

Through analyses of HBV DNA integratns in human cellular DNA, we identified three different integrant types, each of which may reflect the process of primary integrant formation by the viral DNA. The first type, which we call "simple type" consists of integrants found in some hepatocellular carcinomas (HCC's). The structure of the viral genome is simple, and part of it is deleted. The viral cohesive end sequence appears at one of the viral-cellular DNA junctions, and integration has elicited a microdeletion in the target cellular DNA sequence. This structure suggests viral DNA replication intermediates as substrates for integration. Judging from its frequency in HCC, this type may represent the most preferred one, if not all, among the primary integration products. The second type, which we call "complex type" is essentially the same as the first type, except tht the viral genome structure is complex. We considered the possibility that they may have been produced via the same process, using preformed complex viral genomes such as "novel form DNA's" (Rogler and Summers, 1982) as substrates. In cultured fetal hepatocytes, integration of HBV DNA can occur only a few days after infection. Among such integrants, we found a third type integrant, having a simple viral genome, but having a larger cellular DNA deletion. We propose that different forms of viral DNA may be used as substrates in the integration process, and the process is characterized by its eliciting of deletions of different size in the target cellular DNA. The most preferred substrate may be the one producing the simple type integrants, and the most frequently occurring deletion in the target DNA may be the microdeletion.(ABSTRACT TRUNCATED AT 250 WORDS)
Gastroenterol Jpn 1990 Sep
PMID:Different type of hepatitis B virus (HBV) DNA integrants that may reflect the integration process. 217 69

Cellular DNAs of chronically hepatitis B virus (HBV)-infected human livers were analysed by Southern blot hybridization for the presence of integrated HBV DNA. In 15 out of 16 tissue samples, random HBV DNA integration was evident. By molecular cloning and structural analyses of 19 integrants from 3 chronic hepatitis tissues, rearrangement of HBV DNA with inverted duplication or translocation of cellular flanking DNA at the virus-cell junction was noted. Thus, the rearrangement of HBV DNA or cellular flanking DNA not to be a specific incident of HCC formation. Analyses of various integrants bearing HBV DNA rearrangement and their cellular counterpart DNAs failed to indicate any gross structural alteration in cellular DNA except for a small deletion at the integration sites, indicating HBV DNA rearrangement with inverted duplication to possibly occur prior to integration. Based on nucleotide sequencing analyses of virus-virus junctions, a mechanism of this inverted duplication of HBV DNA is proposed, in which an illegitimate recombination may take place by means of a patchy homology on one side of adjoining viral sequences.
Gastroenterol Jpn 1990 Sep
PMID:Integrated structures of HBV DNA in chronic hepatitis and hepatoma tissues. 217 70

Reported is the case of a 67-year-old man with an HCC who was being treated by percutaneous ethanol injection therapy (PEIT). After a year, CT and ultrasonography demonstrated the dilatation of the intrahepatic bile duct and the atrophy of the right lobe. Endoscopic cholangiography also showed stenosis of the right hepatic duct. This severe complication and injury to the hepatic duct and portal vein was determined as having occurred because of treatment by PEIT.
Gan No Rinsho 1990 Sep
PMID:[A hepatocellular carcinoma (HCC) with intrahepatic bile duct dilatation and right lobe atrophy following percutaneous ethanol injection therapy]. 217 84

To evaluate the diagnostic value of Lipiodol-CT for small hypovascular HCC, we injected 3 ml or less Lipiodol into the hepatic artery of patients with chronic liver disease and small SOL in the liver detected on echogram but not on angiogram. About seven days after injection CT was used to check for accumulation of Lipiodol in the liver SOL. We found that the sensitivity of this method for detection of hypovascular HCC is only 25%. We assume that Lipiodol does not accumulate in small hypovascular HCC lesions because they have little vascular stroma. Lipiodol-CT has high diagnostic value for the detection of small hypervascular daughter HCC lesions, but this method should not be relied on for the detection of small hypovascular HCC.
Rinsho Hoshasen 1990 Sep
PMID:[Lipiodol-CT for the detection of small hypovascular HCC]. 217

Insulin-like growth factor II (IGF-II) is a polypeptide growth factor thought to be involved in fetal tissue development. We previously showed an increased expression of IGF-II mRNA in human primary liver cancer. The present investigation was undertaken to characterize the overexpressed IGF-II transcripts and to determine whether they are translated into protein. Two cDNAs with distinct 5' untranslated regions, corresponding to IGF-II transcripts expressed in fetal liver, were isolated from a primary liver cancer. Complete nucleotide sequence analysis showed an identical open reading frame of 540 bp, encoding a predicted polypeptide identical to the IGF-II isolated from serum. An increased synthesis of IGF-II protein was demonstrated by a protein-binding assay in tumorous liver samples, the highest levels being found in primary liver cancers with the highest IGF-II steady state level. By contrast, serum IGF-II content was low in most of primary liver cancer cases analyzed. Altogether, the results indicate reexpression of IGF-II both at the mRNA and protein levels in primary liver cancer. This finding is consistent with IGF-II being a marker of liver cell differentiation. In addition, this growth factor might be involved in liver cancer progression by an autocrine and/or paracrine mechanism.
J Hepatol 1990 Sep
PMID:Expression of insulin-like growth factor II (IGF-II) in human primary liver cancer: mRNA and protein analysis. 217 34

Recent time trends (1979-1987) and geographical distributions in mortalities from subsites of cancers of the hepato-biliary-pancreatic system have been investigated on the basis of the vital statistics of Japan. The corrected age-adjusted mortality rates (CAAMRs) were calculated to eliminate the influence of the proportion of subsite-unknown cancers. During the above period, the CAAMR for intrahepatic bile duct cancer increased by a relatively high extent (2.0-fold in males and 1.67-fold in females), and those for cancers of the gallbladder, extrahepatic bile duct and pancreas (head and other parts) increased to a moderate extent (1.2-1.4-fold). The CAAMR for primary liver cancer showed an increasing trend in males and a decreasing trend in females. The CAAMR for cancer of the ampulla Vater changed little during the period. A clear cluster of prefectures with high CAAMRs was observed in the northern part of Japan for cancers of the extrahepatic bile duct and pancreatic head. Clusters of prefectures with high CAAMRs for cancer of the gallbladder and ampulla Vater were observed in the mid-northern part of Japan, especially on the Japan Sea side. The CAAMR for primary liver cancer was high in the Island of Kyushu and some western parts of Japan, and low in the northern part of Honshu Island. No clear clusters of prefectures with high CAAMRs were observed for cancers of the intrahepatic bile duct and pancreas, other than for the pancreatic head.
Jpn J Clin Oncol 1990 Sep
PMID:Descriptive epidemiology of subsites of cancers of the liver, biliary tract and pancreas in Japan. 225

Ganglioside on the cell membrane surface was isolated from human primary liver cancer of different origins (10 surgical specimens from patients, 4 tumor tissues from nude rats bearing transplanted human liver cancer and 2 human liver cancer cell lines) and compared with that of normal liver from men and nude rats. The results of TLC pattern showed that GM3 was the main constituent, comprising about 95% of the total gangliosides in the normal liver. However, it decreased in liver cancer whereas GM2 was increased markedly in most of the liver cancers, GD3 came next. By CS-910 scanning, the contents of GM3, GM2 and GD3 were 60.2%, 20.6% and 7.9% in surgical specimens; 46.1%, 29.7% and 11.9% in nude rats bearing human liver cancer and 25.2%, 47.6% and 0% in cell lines. GM2 and GD3 on the cell surface of liver cancer were determined with monoclonal antibodies or anti-serum against gangliosides. The results obtained conformed with the TLC pattern.
Zhonghua Zhong Liu Za Zhi 1990 Sep
PMID:[Spectrum pattern and determination of ganglioside from human primary liver cancer of different origins]. 227 22

A prognostic study on 119 patients with primary liver cancer undergoing nonsurgical therapy was carried out to evaluate the relevance of hepatic functional reserve and tumor size to their cumulative survival rates. All patients were classified into the three groups of Child's classification (A, B and C) according to their hepatic functional reserve and were also divided into the five groups according to their tumor size. The cumulative survival rates of all patients at 1, 2, 3, 4 and 5 years after the diagnosis were 50.9, 28.3, 18.8, 13.5 and 6.7%, respectively. The cumulative survival rates of group V whose tumor occupied more than 40% of the liver area were significantly lower than those of the other tumor-size-groups. The survival rates of Child's group A were significantly higher than those of group B and C. But in those patients who were classified into group V according to their tumor size, there was no significant difference in their survival rates among the three groups of Child's classification. These results suggest that hepatic functional reserve as well as tumor size is an important prognostic factor in patients with primary liver cancer. But if the cancer once develops greater than 40% of the liver area, hepatic functional reserve diminishes in value as a prognostic factor.
Fukuoka Igaku Zasshi 1990 Sep
PMID:[Hepatic functional reserve and tumor size as prognostic factors in patients with primary liver cancer undergoing non-surgical therapy]. 227 13


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