Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0345904 (
liver cancer
)
15,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
N6-Methyladenosine
(m
6
A) modification has been implicated in the progression of several cancers. We reveal that during epithelial-mesenchymal transition (EMT), one important step for cancer cell metastasis, m
6
A modification of mRNAs increases in cancer cells. Deletion of methyltransferase-like 3 (METTL3) down-regulates m
6
A, impairs the migration, invasion and EMT of cancer cells both in vitro and in vivo. m
6
A-sequencing and functional studies confirm that Snail, a key transcription factor of EMT, is involved in m
6
A-regulated EMT. m
6
A in Snail CDS, but not 3'UTR, triggers polysome-mediated translation of Snail mRNA in cancer cells. Loss and gain functional studies confirm that YTHDF1 mediates m
6
A-increased translation of Snail mRNA. Moreover, the upregulation of METTL3 and YTHDF1 act as adverse prognosis factors for overall survival (OS) rate of
liver cancer
patients. Our study highlights the critical roles of m
6
A on regulation of EMT in cancer cells and translation of Snail during this process.
...
PMID:RNA m
6
A methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. 3106 16
N6-Methyladenosine
(m
6
A) is the most abundant and important internal modification site of RNA methylation in viruses and eukaryotic. m
6
A RNA methylation plays key roles in the regulation of post-transcriptional gene expression, including messenger RNA (mRNA), microRNA (miRNA) and long noncoding RNA (lncRNA). And m
6
A methylation regulates the various aspects of RNA metabolism, including structure, maturation, stability, splicing, export, translation and decay. Liver is a vital metabolic and digestive organ in the pathophysiological processes. Recent studies suggested that m
6
A RNA modification highly regulates hepatic function and development of liver diseases. Here, we aim to summarize the biological and clinical significance of m
6
A modification in hepatic growth and hepatic disease including viral hepatitis, non-alcoholic fatty liver disease (NAFLD), and
liver cancer
.
...
PMID:Role of identified RNA N6-methyladenosine methylation in liver. 3107 30
