Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Reported herein is an autopsy case of primary hepatic neuroendocrine carcinoma associated with dermatomyositis. A 71-year-old Japanese man, who was diagnosed with dermatomyositis 5 months before death, had multiple tumors within a non-cirrhotic liver. Histopathologically, the tumors were composed of small- and medium-sized round cells with clear cytoplasm arranged in nests, sheets or rosettes. Immunohistochemically, the tumor cells were positive for chromogranin A, neuron-specific enolase and CD56 and were negative for synaptophysin. This tumor was diagnosed as a primary hepatic neuroendocrine carcinoma with metastasis to the lung, gallbladder and lymph nodes around the pancreas and aorta; no primary lesions were detected in any other organ. The tumor cells were also positive for cytokeratin 7, cytokeratin 19 and epithelial membrane antigen but were negative for anti-hepatocyte antibody and AFP. These findings suggest that the tumor originated in intrahepatic bile duct epithelium. Various cancers have been reported in patients with dermatomyositis, but only seven cases of dermatomyositis associated with primary liver cancer have been reported. To the best of the authors' knowledge, this is the first report of dermatomyositis associated with primary hepatic neuroendocrine carcinoma.
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PMID:Neuroendocrine carcinoma of the liver associated with dermatomyositis: autopsy case and review of the literature. 1709 33

A 71-year-old man was admitted to our institution having a HCC with tumor thrombus extending to the inferior vena cava. He simultaneously had a sigmoid colon cancer. S8 segmentectomy combined with a removal of tumor thrombus in the IVC and sigmoidectomy was performed. He had an uneventful postoperative course. He had a recurrence to the lung 46 months after the surgery, and underwent a pulmonary partial resection. Hepatic recurrence was found in 59 months after the initial surgery. Transcatheter arterial chemoembolization was performed for the treatment. The patient died of esophageal variceal rupture 78 months after the surgery. Although this case was a highly advanced hepatocellular carcinoma with tumor thrombus in the inferior vena cava and synchronous sigmoid colon cancer, a surgical treatment and multidisciplinary therapy may contribute to a long-term survival.
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PMID:[Aggressive surgical treatment prolonged survival of a patient with synchronous hepatocellular carcinoma with tumor thrombus in the inferior vena cava and sigmoid colon cancer]. 1821 86

We report a long-term survival case of hepatocellular carcinoma with lymph node metastases treated with surgery and radiotherapy. A 71-year-old man was admitted to our department at Kumamoto University Hospital in May 2003 for a treatment of local recurrent HCC after transarterial chemoembolization. CT showed an infiltrative type tumor, 2.5 cm in diameter, in the segment 8 of the liver. We treated the liver tumor with a right paramedian sectionectomy in May 2003. Postoperatively, lymph node metastases and recurrent HCC were diagnosed. Three times of local ablation therapies for recurrent HCC, twice lymph node dissections, and twice radiotherapies for lymph node metastases were successfully achieved. The patient survived without recurrence for 60 months after the initial hepatectomy.
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PMID:[A long-term survival case of hepatocellular carcinoma with lymph node metastases treated with surgery and radiotherapy]. 1910 35

We examined patients who were treated for another cancer during treatment for primary and recurrent liver cancer. Case 1: A 71-year-old man underwent hepatectomy for hepatocellular carcinoma (HCC). Ten months after the surgery, a pancreatic tumor and multiple liver metastases of HCC were observed. After transarterial chemoembolization was performed to control HCC, the pancreatic cancer was resected. Case 2: A 76-year-old woman underwent liver resection for HCC. Six months after the surgery, gastric cancer and multiple liver metastases of HCC were observed. Transarterial chemoembolization was performed to control HCC, and S-1 was administrated for the gastric cancer. These treatments were repeated for about 1 year with 1 course per 6 week. Case 3: A 59-year-old man underwent hepatectomy for HCC. One year after the surgery, thyroid cancer was detected and was resected. About 7 years after the first surgery, recurrent HCC was noted and resected. Case 4: A 69-year-old man underwent hepatectomy for intrahepatic cholangiocarcinoma (ICC). Two months after the surgery, esophagectomy was performed for synchronous esophageal cancer. Thereafter, hepatectomy was repeated or radiofrequency ablation was performed for liver metastases of ICC. Primary liver cancer is associated with a high recurrence rate. So long as the primary and recurrent liver cancer is properly controlled, treatment for other cancers is possible.
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PMID:[Treatments of Other Cancers and Liver Metastases after Hepatectomy for Liver Cancers]. 2680 34