Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors point out that when TEP are planned more attention is paid to the type of prosthesis, its composition and technical parameters and less attention to the quality of osseous tissue which is the subject of the present work. The authors examined at the First Orthopaedic Clinic Medical Faculty Comenius University Bratislava by means of a densitometer LUNAR DPX L the neck of the femur in patients before implantation of a TEP. They examined 96 coxae in patients with an average age of 57 years. Primary coxarthrosis accounted for 48%, bionecrosis of the head for 21%, deforming coxarthrosis (condition following LCC) 12%, rheumatoid arthritis 9%, conditions after fractures of the neck of the femur 9%. In the first group the bone density - BMD per g/cm2 in the neck of the femur (K) was 0.996 (109%), of Ward's triangle (W) 0.902 (118%), of the trochanter (T) 0.748 (106%). Values in the other groups: Group 2: K = 0,823 (93 %), W = 0,702 (91 %), T = 0,587 (76 %). Group 3: K = 0,987 (107%), W = 0,814 (99%), T = 0,684 (89 %). Group 4: K = 0,740 (83 %), W = 0,586 (74 %), T = 0,479 (64 %). Group 5: K = 0,604 (66 %), W = 0,533 (68 %), T = 0,513(63%). The results indicate that in idiopathic coxarthrosis the density is normal or elevated, in deforming coxarthrosis the coxa is difficult to examine by means of our software. In rheumatoid arthritis bionecrosis and mainly after fractures is density reduced. Reduced bone density is associated with the firmness of the fixation of TEP. Key words: DEXA, DPX, bone density, total endoprosthesis.
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PMID:[Mineralization of the Coxa (DPX) before Implantation of TEP.]. 2044 72

Previously we have generated inducible liver tumor models by transgenic expression of Myc or xmrk (activated EGFR homolog) oncogenes in zebrafish. To investigate the interaction of the two oncogenes, we crossed the two transgenic lines and observed more severe and faster hepatocarcinogenesis in Myc/xmrk double transgenic zebrafish than either single transgenic fish. RNA-Seq analyses revealed distinct changes in many molecular pathways among the three types of liver tumors. In particular, we found dramatic alteration of cancer metabolism based on the uniquely enriched pathways in the Myc/xmrk tumors. Critical glycolytic genes including hk2, pkm and ldha were significantly up-regulated in Myc/xmrk tumors but not in either single oncogene-induced tumors, suggesting a potential Warburg effect. In RT-qPCR analyses, the specific pkm2 isoformin Warburg effect was found to be highly enriched in the Myc/xmrk tumors but not in Myc or xmrk tumors, consistent with the observations in many human cancers with Warburg effect. Moreover, the splicing factor genes (hnrnpa1, ptbp1a, ptbp1b and sfrs3b) responsible for generating the pkm isoform were also greatly up-regulated in the Myc/xmrk tumors. As Pkm2 isoform is generally inactive and causes incomplete glycolysis to favor anabolism and tumor growth, by treatment with a Pkm2-specific activator, TEPP-46, we further demonstrated that activation of Pkm2 suppressed the growth of oncogenic liver as well as proliferation of liver cells. Collectively, our Myc/xmrk zebrafish model suggests synergetic effect of EGFR and MYC in triggering Warburg effect in the HCC formation and may provide a promising in vivo model for Warburg effect.
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PMID:Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. 2614 4