Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Seven new nitrogen heterocycle porphyrins, 5,10,15,20-tetra[4-(N-pyrrolidinyl)phenyl]porphine (TBPPH(2)), 5,10,15,20-tetra[4-(4'-ethylpiperazinyl)phenyl]porphine (TEPPH(2)), 5,10,15,20-tetra [4-(4'-butylpiperazinyl)phenyl]porphine (TUPPH(2)), 5,10,15,20-tetra[4-(4'-heptylpiperazinyl) phenyl]porphine (THPPH(2)), 5-[4-(4'-ethylpiperazinyl)phenyl]-10,15,20-triphenylporphine (MEPPH(2)), 5-[4-(4'-buthylpiperazinyl)phenyl]-10,15,20-triphenylporphine (MUPPH(2)) and piperazine bridge porphine dimer N,N'-di(5,10,15,20-tetraphenylporphinato)piperazine (DiPPH(2)) have been synthesized by the direct condensation of nitrogen heterocycle substituted benzaldehydes with pyrrole. Each porphine bears one or four substituted pyrrolidine or piperazine moieties that have been used as drugs. Their structures were characterized by elementary analysis, MS, 1H NMR, IR and UV-vis. These nitrogen heterocycle porphyrins aggregates in water and THF solution were studied by the spectrophotofluorimetry. The anticancer activity of these porphines for the liver cancer cells, the stomach tumor cells and the nasopharyngeal carcinoma cancer cells were tested by the MTT assay. Compared with cis-platinum (cis-Pt) and 5-Fluorouracil (5-Fu), the nitrogen heterocycle porphyrins have the better biological activity and might have potential application in medicine.
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PMID:Study on synthesis, characterization and biological activity of some new nitrogen heterocycle porphyrins. 1265 60

Reaction of trans-(dmpe) 2CrCl2 (dmpe=1,2-bis(dimethylphosphino)ethane) with one equivalent of LiCCSiMe3 and one equivalent of nBuLi in THF under a dinitrogen atmosphere affords dark orange trans,trans-[(Me 3SiCC)(dmpe)2Cr]2(micro-N2).hexane (1). Under similar conditions but in the absence of acteylide ligand, the reaction of trans-(dmpe)2CrCl2 with 2 equivalents of nBuLi yields the previously characterized complex trans-(dmpe)2Cr(N2)2 (2), while the reaction of trans-(dmpe)2CrCl2 with 2 equivalents of LiCCSiMe3 in THF yields trans-(dmpe)2Cr(CCSiMe3)2 (3). Compound 3 can also be synthesized by irradiating a mixture of trans-(dmpe)2CrMe2 and HCCSiMe3 or by reduction of HCCSiMe3 with compound 2. The magnetic properties, electrochemistry, and crystal structure of trans,trans-[(Me3SiCC)(dmpe)2Cr]2(micro-N2) are consistent with the complex containing two CrI ions bridged by a neutral N2 moiety, with a 1.178(10) A N[TRIPLE BOND]N bond distance. For complex 1 redox processes centered at E1/2=-1.69 V (DeltaEp=185 mV) and -1.43 V (DeltaEp=182 mV) versus Fe(Cp)2/Fe(Cp)2+ are assigned to the CrICrI/CrICrII and CrICrII/CrIICrII couples, respectively. For trans-(dmpe)2Cr(CCSiMe3)2 a reversible couple assigned as the CrII/III couple was observed at -1.59 V (DeltaEp=242 mV) versus Fe(Cp)2/Fe(Cp)2+. The dinuclear CrI-dinitrogen complex 1 has a room temperature magnetic moment of 2.77 microB while compound 3 displays a moment of 2.55 microB. Density-functional theory calculations performed on a model compound of 1, namely, trans,trans-[(HCC)(dpe)2Cr]2(micro-N2) (dpe=diphospinoethane), indicate that oxidation of the molecule should result in weakening of the dinitrogen triple bond.
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PMID:Dinitrogen and acetylide complexes of low-valent chromium. 1845 23