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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The present study defines the clinical presentation and examines possible aetiological factors in the occurrence of hepatocellular carcinoma in Karachi, Pakistan. Histologically proven cases of hepatocellular carcinoma (n = 366) were seen over 16 years. The maximum frequency occurred in the age range 51-60 years (range: 8-98 years), and the male to female ratio was 2.5:1. The place of birth, place of longest stay and various addictions did not have any association with the occurrence of liver carcinoma. Only three cases had a history of liver cancer in their immediate relatives. The main presenting features were right hypochondrial mass (85%) and pain (79%). The liver size did not correlate with the duration of illness. alpha-Fetoprotein titres were more than 200 ng/mL in 62% of cases. Using a reverse passive haemagglutination assay method, HBsAg and anti-HBc positivity were 32% and 60%, respectively. Antigen figures rose to 60% when radio-immunoassay was used; 41% of cases were anti-delta positive (EIA). Aflatoxin contamination varied between 10% and 17% in various localities of Karachi, suggesting an association of liver cancer with HBsAg and aflatoxins. Histopathologically 73% were trabecular, and 2.5% were mixed hepatocholangiocarcinomas. Follow-up was available in 45% of cases. All except two (1.2%) died within 6 months.
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PMID:Hepatocellular carcinoma in Karachi. 171 78

A 54-yr-old man with multiple metastatic liver cancer was admitted to our hospital because of melena and intermittent colicky pain on the right upper abdomen. He underwent partial gastrectomy for gastric cancer 3 yr before the admission. Endoscopic examination of the duodenum on the 3rd hospital day showed active bleeding from the papilla of Vater, and diagnosis of hemobilia was done. Transcatheter arterial embolization controlled the bleeding successfully, and no rebleeding occurred until his death due to the advanced cancer 8 months later. We considered that the high vascularity of his metastatic tumor caused hemobilia. To the best of our knowledge, this is the first report of hemobilia by metastatic liver cancer treated successfully with transcatheter arterial embolization.
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PMID:Successful control of hemobilia secondary to metastatic liver cancer with transcatheter arterial embolization. 195 Dec 43

Multi-institutional studies on clinical hyperthermia of deep-seated tumours were undertaken using 8 MHz radiofrequency capacitive heating devices (Thermotron RF-8) at seven institutions. Each institute was designated to treat specific organs. This paper contains the accumulations of the results obtained at different institutions charged for different tumours. Deep-seated tumours in the lung, stomach, pancreas, liver, urinary bladder and rectum were treated. A total of 177 cases examined from January 1985 to December 1988 included 96 cases (54%) treated with radiotherapy plus hyperthermia, among which 14 cases were pre-operative. Of 177 cases, 81 (46%) were treated with chemotherapy plus hyperthermia. Complete response (CR) and partial response (PR) were obtained in 80% of the cases with lung cancer, 39% with stomach cancer, 56% with liver cancer, 35% with pancreas cancer, 71% with urinary bladder cancer, 100% with primary rectal cancer, and 47% with recurrent rectal cancer. Thermometry was performed using two techniques; one is direct measurement of intratumour temperature in lung and liver cancers, the other is indirect measurement of intracavitary temperature for stomach, pancreas, urinary bladder and rectal cancers. Intratumour temperatures were measured in 30 of the 43 tumours of the lung and liver. The maximum tumour temperature was greater than 42 degrees C in 23 (77%) of the 30 tumours. Intracavitary temperatures were measured in 133 (99%) of the 134 tumours of stomach, pancreas, urinary bladder and rectum. An intracavitary temperature greater than 42 degrees C was obtained in 98 (73.7%) of the 133 tumours. The contribution of hyperthermia in improving the quality of life of patients under terminal care was also investigated. It was indicated that hyperthermia was one of the most effective treatment techniques for advanced or inoperable cases. In this study local control rate (LCR) was mainly discussed because the period of follow-up was only 3 years. Side-effects were observed in 37 cases (21%); main side-effects were fatty induration, pain during treatment and burn. However, no side-effects were severe enough to interrupt therapy.
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PMID:Multi-institutional clinical studies on hyperthermia combined with radiotherapy or chemotherapy in advanced cancer of deep-seated organs. 220 48

This paper deals with 70 cases of primary liver cancer treated by externally applying Pu Tuo plaster and internally taking oral Chinese herbal medicine. In term of the statistic, of all the cases applied the plaster, 96.7% has proved to be effective in alleviating the pain, 83.5% was remarkable. It has significantly improved the quality of the patients' later lifes. Applying Pu Tuo plaster with taking oral Chinese herbal medicine, the patients could survive longer. On average, after the treatment, the patient could live ten and half months, 44.8% of the II-stage liver cancer patients applied the plaster could live as long as one year, the longest one has been living more than 2 years and 8 months, he looks still well now. He has been working since 1987. In recent B-ultrasonic examination, the patient's primary focus disappeared, and alpha-fetoprotein test turned to be negative.
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PMID:[Analysis of 70 cases of primary liver carcinoma treated by pu tuo ointment and herbs]. 229 17

Discriminant analysis was used in evaluating the importance of clinical aspects and the value of routine and experimental biochemical markers in the differential diagnosis of primary liver cancer (PLC) and chronic, non-neoplastic, liver diseases. Our results show that: 1) Clinical signs, such as the presence of pain, weight loss or mass, correctly indicate the diagnosis in 76% of the cases; 2) The determination of alkaline phosphatase isoenzymes is shown by the computer to be the most useful marker and provides an overall diagnostic accuracy which is higher than that of alpha-fetoprotein. We also found that, by using these two markers together, "by intersection," the best overall accuracy (85%) is obtained. We, therefore, suggest determination of alkaline phosphatase isoenzymes and alpha-fetoprotein in screening the populations at risk for liver cancer.
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PMID:Discriminant analysis in the clinical and biochemical diagnosis of primary liver cancer. 243 64

The composite substance of Mitomycin C (MMC) and polymer by low temperature radiating polymerization has a characteristic of slow release, the possibility of applying it to local chemotherapy was clinically studied. Buttom-formed preparation (MMC 20 mg) and needle-formed preparation (MMC 5 mg) were applied to the lesions, respectively, by sewing and piercing in 220 cancer patients with non resectable infiltrative lesions. The treatment had a pain-relieving effect in 70 out of 117 cases (60.0%) of painful cancer in the pancreas, biliary duct, liver, etc, and improved the symptoms of digestive organs in 31 out of 93 cases (33.3%). However, the tumor-reducing effect was recognized only in minute localized lesions of hepatic cancer, etc., and the survival period was not prolonged. The treatment caused no severe side effects. From the above results, the local chemotherapy with slow-releasing MMC preparation was concluded to be a useful means of palliative therapy in non-resectable, though its formulation may to be further improved.
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PMID:[Clinical study of controlled-release preparation of mitomycin C in the treatment of inoperable cancer patients]. 246 Nov 68

Between December 1986 and January 1978, 68 patients with bone metastases were analyzed to evaluate the effect of radiation for the relief of pain. The 68 patients, who had a total of 97 lesions, complained of pain caused by their bone metastasis. The good, fair, and poor responses were found to be 18%, 60%, and 22%, respectively. With reference to the primary neoplasms, the effective response rate was 73% in lung cancer, 100% in breast cancer, 75% in gastric cancer, 100% in hepatic cancer, 100% in bladder cancer, 25% in epipharyngeal cancer, and 70% in the other neoplasms. Depending on the cell types of the lung cancer, the effective response rate was 80% for small cell carcinomas, 72% for adenocarcinomas and 40% for squamous cell carcinomas. Our results suggest that radiotherapy for bone metastases is to be recommended, since the effective response rate was 78% for the relief of pain.
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PMID:[Radiotherapy in bone metastases--with special reference to its effect on relieving pain]. 255 Jun 86

In 169 cases with liver cancer pain, the therapeutic effects of TCM and the authors' "analgesic therapy of four steps" were analysed. The results were that most patients with advanced liver cancer had mild pain, and only a small number of patients (14.2%) had moderate or severe pain. By the first step analgesic therapy, 46.1% of the patients were relieved and with the second or third step of analgesic therapy, 93.5% of the patients were relieved, only 6.5% of the patients with grade III pain needed the fourth step therapy. With TCM treatment alone, the remission rate of grade I and grade II pain was 100% and 76.9% respectively. "Analgesic therapy of four steps" produced less side effects or addiction to narcotics.
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PMID:Treatment of pain according to syndrome differentiation in 169 cases of liver cancer. 256 Oct

Chemoembolization with degradable starch microspheres (DSM) was performed in twelve cases of hepatocellular carcinoma, one case of cholangioma, and one case of metastatic liver cancer. The following results were obtained. (1) Tumor regression of over 50% was observed in eight of fourteen cases. Tumor regression of over 25% was obtained in ten of fourteen cases. (2) Half of the cases had fever, pain and leukocytopenia, but they were slight and transient. (3) Implantable drug delivery system (Port-A-Cath) was applied for intra-arterial chemoembolization in four cases. The longest implantation period was 662 days and 33 infusions were made. These results suggest that chemoembolization with DSM can be effectively used in the treatment of malignant hepatic tumors.
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PMID:[Treatment with degradable starch microspheres (DSM) in malignant hepatic tumors-clinical experience of implantable drug delivery system (Port-A-Cath)]. 284 29

Metastasis of the cervical spine or pathological fracture respectively presents a demanding therapeutical task. Pain and threatening, neurological deficit require an active action, even if curative treatment is unlikely. The remaining survival time after appearance of osseous metastasis is on the average nine to twelve months and justifies an operation, especially in view of psychosocial consequences for the patient. We are describing the unique case of cervical spinal manifestation after liver transplantation because of primary hepatic cancer.
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PMID:[Occipitocervical fusion in metastasis to the dens]. 285 Dec 3


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