Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
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Query: UMLS:C0345904 (
liver cancer
)
15,188
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To screen out copy number variation (CNV)-driven differentially expressed genes (DEGs) in
liver cancer
and advance our understanding of the pathogenesis, an integrated analysis of
liver cancer
-related CNV data from The Cancer Genome Atlas (TCGA) and gene expression data from EBI Array Express database were performed. The DEGs were identified by package limma based on the cut-off of |log2 (fold-change)|>0.585 and adjusted p-value<0.05. Using hg19 annotation information provided by UCSC,
liver cancer
-related CNVs were then screened out. TF-target gene interactions were also predicted with information from UCSC using DAVID online tools. As a result, 25 CNV-driven genes were obtained, including tripartite motif containing 28 (TRIM28) and
RanBP-type and C3HC4-type zinc finger containing 1
(
RBCK1
). In the transcriptional regulatory network, 8 known cancer-related transcription factors (TFs) interacted with 21 CNV-driven genes, suggesting that the other 8 TFs may be involved in
liver cancer
. These genes may be potential biomarkers for early detection and prevention of
liver cancer
. These findings may improve our knowledge of the pathogenesis of
liver cancer
. Nevertheless, further experiments are still needed to confirm our findings.
...
PMID:Identification of copy number variation-driven genes for liver cancer via bioinformatics analysis. 2517 35
