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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

During the period of 1975-1989, in the Belgrade population increasing mortality trends were established for colon and rectal cancer, cancer of the pancreas and gallbladder and bile ducts cancer, for both sexes, and for esophageal cancer in males. Stomach and liver cancer mortality decreased in females. In males, stomach cancer mortality after a prolonged steady decrease suddenly rose in the years 1988 and 1989. Mortality rates series for esophageal cancer in females and for liver cancer in males did not fit any usual trend function.
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PMID:Trends in cancer mortality of the digestive tract in Belgrade, Yugoslavia, 1975-1989. 795

The medical records of 267 patients who had liver tumors, primary and metastatic, from 1988 to 1995 were retrospectively reviewed. Two hundred thirteen patients (80%) had metastatic disease, and 54 patients (20%) had primary liver disease. Their clinical manifestations and laboratory values were evaluated as factors predictive of diagnosis and survival. There was a significant increase in the occurrence of upper abdominal pain, weight loss, extrahepatic symptoms due to the metastatic origin, and hepatomegaly. Metastases from colorectal primary lesions were synchronous in 34 patients and metachronous in 31 patients. Stomach, lung, and pancreatic primaries were more commonly synchronous. Breast metastases were more commonly metachronous. Elevated serum glutamic-oxaloecetic transaminase and alkaline phosphatase and decreased albumin were the most common liver test abnormalities at diagnosis. Carcinoembryonic antigen values were elevated in the majority of colon cancer patients. Eighty-one percent of patients with primary liver cancer had elevated levels of alpha-fetoprotein, 40 per cent were seropositive for hepatitis B, and 23 per cent were seropositive for hepatitis C. Seventy-nine patients (30%) underwent surgery for their cancer, 37 (47%) had resections, 38 (48%) were unresectable, and 4 (5%) underwent liver transplantation. The patients who underwent surgery had a 32 per cent 5-year survival rate compared to a 0 per cent 5-year survival in the patients who did not have surgery (p = 0.0001). The patients who had resections had a better survival rate than those deemed unresectable at surgery (62% versus 0% at 5-years with p = 0.0008). The perioperative morbidity rate was 16 per cent, with lobectomies having the best rate and trisegmentectomies having the worst. Perioperative mortality rate was zero for all liver resections. Hepatic resection and, in selected patients, liver transplantation are the only two available therapeutic modalities that produce long-term survival with a possible cure in patients with primary and metastatic liver tumor.
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PMID:Surgical and nonsurgical management of primary and metastatic liver tumors. 952 Aug 9

Pattern of gastro-intestinal malignancies differ in different geographical areas and depends upon the genetic, cultural, dietary and socioeconomic factors. Therefore studying pattern of gastro-intestinal cancers help to identify high risk groups, recommend preventive measures or advise appropriate screening in high risk population. The present study was undertaken to determine the pattern of gastrointestinal malignancies at Kolar, situated in south-eastern part of Karnataka. A ten-year retrospective study from January 1997 to December 2006 was done at the department of pathology at Sri Devaraj Urs Medical College, Kolar, Karnataka. All the gastro-intestinal malignancies diagnosed were retrieved from pathology department records and socio-epidemiological data regarding each case was collected from hospital record section. The cases were analysed for site of involvement, age distribution, histological types and yearwise distribution by descriptive analysis. Gastro-intestinal malignancies constituted 22.96% of all the malignancies diagnosed. Males were more frequently affected than females, M:F ratio was 1:0.6. Peak incidence was in 7th decade. Stomach was the commonest site (48.4%) followed by oesophagus (27.7%), rectum (6.5%), colon (5.0%) and primary liver cancer (4.76%). Majority of histological type was adenocarcinoma. Yearwise distribution showed gradual increase in incidence of cancer. In the present study gastro-oesophageal malignancies was the most common gastro-intestinal malignancy in this part of Karnataka which in turn reflects on potential lifestyle and environmental factors.
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PMID:Spectrum of gastro-intestinal cancers--a ten-year study. 2151 May 49