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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 69 bladder cancer, 76 lung cancer and 59 liver cancer deceased cases and 368 alive community controls group-matched on age and sex were studied to evaluate the association between high-arsenic artesian well water and cancers in the endemic area of blackfoot disease (BFD), a unique peripheral vascular disease related to continuous arsenic exposure. According to a standardized structured questionnaire, information on risk factors was obtained through proxy interview of the cases and personal interview of the controls. A positive dose-response relationship was observed between the exposure to artesian well water and cancers of bladder, lung and liver. The age-sex-adjusted odds ratios of developing bladder, lung and liver cancers for those who had used artesian well water for 40 or more years were 3.90, 3.39, and 2.67, respectively, as compared with those who never used artesian well water. Multiple binary logistic regression analyses showed that the dose-response relationships and odds ratios remained much the same while other risk factors were further adjusted.
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PMID:A retrospective study on malignant neoplasms of bladder, lung and liver in blackfoot disease endemic area in Taiwan. 396 42

This paper briefly reviews the health hazards associated with smoking, including passive smoking, with specific reference to local (Hong Kong) evidence. A Medline search of Hong Kong papers from January 1966 to January 1998 was made, and these and other relevant papers were reviewed. In Hong Kong, at least 10 people die daily from smoking- related diseases. Local studies show that smoking is associated with lung cancer, oesophageal cancer, liver cancer, ischaemic heart disease, peripheral vascular disease, ischaemic stroke, peptic ulcer, osteoporosis, impaired lung function, respiratory symptoms, and other adverse health effects. Smoking in pregnant women can result in smaller babies being born. Pooled results from four case-control studies show a 60% excess risk of lung cancer due to exposure to environmental tobacco smoke. Several studies confirm the link between exposure to environmental tobacco smoke and respiratory illness, hospitalisation, and asthma in children. The risks of smoking (one of every two smokers will be killed by tobacco) are not well known and are underestimated by both doctors and the public. Stronger health messages and more local evidence are needed to support tobacco control in Hong Kong.
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PMID:The public health harm of tobacco and its prevention in Hong Kong. 1183 Jul 5

Arsenic has been well documented as the major risk factor for development of blackfoot disease (BFD), a unique peripheral vascular disease that was once endemic to the southwestern coast of Taiwan, where residents imbibed artesian well water containing high concentrations of arsenic for more than 50yr. Long-term arsenic exposure has also been reported to be associated with increased incidence of liver cancer in a dose-responsive manner. A tap-water supply system was implemented in the early 1960s in the BFD endemic areas. Artesian well water was no longer used for drinking and cooking after the mid-1970s. The objective of this study was to examine whether liver cancer mortality rates were altered after the consumption of high-arsenic artesian well water ceased and, if so, when the reduction occurred. Standardized mortality ratios (SMRs) for liver cancer were calculated for the BFD endemic area for the years 1971-2000. Cumulative-sum techniques were used to detect the occurrence of changes in the SMRs. The study results show that mortality from liver cancer in females declined starting 9yr after the cessation of consumption of high-arsenic artesian well water. However, data show fluctuations in male liver cancer mortality rates. Based on the reversibility criterion, the association between arsenic exposure and liver cancer mortality is likely to be causal for females but not in males.
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PMID:Does arsenic exposure increase the risk for liver cancer? 1537 Dec 25