Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0345904 (liver cancer)
 15,188 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Histologic and immunofluorescence studies were done in the murine kidneys (strain C3HAvy) suffering a spontaneous cancer of the liver. Proliferative glomerulonephritis has been found in 17 animals and memranproliferative glomerulonephritis with "wire loop" appearance in 6 animals. The glomeruli of all animals presented immune complex deposition in the mesangium and along the glomerular basement membrane. Furthermore, heavy intensity of IgG complex deposition was observed in animals with membranproliferative glomerulonephritis. The latter animals had developed a poorly differentiated liver cancer.
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PMID:Glomerulonephritis in malignant extra-renal neoplasms. Experimental study on mice using the method of immunofluorescence. 20 29

The article describes the case of a 42 year old woman who died of liver cell carcinoma; the woman had been on oral contraceptives (OCs) for 10 years. The association between OCs and liver cancer is being reported more and more frequently. Still, it is not clear exactly which is the mechanism that causes the malignant tumor. If coincidence and preexisting tumor are ruled out, it is possible that OCs, diminishing biliar excretion, help the accumulation of carcinogenetic substances.
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PMID:[Liver cell carcinoma associated with oral contraceptives (author's transl)]. 20 78

Preventive immunization is the cheapest and most effective approach to the management of epidemic disease. Certain forms of cancer, including Burkitt's lymphoma, carcinoma of the cervix, primary liver cancer, acute leukaemia and breast cancer show many characteristics of epidemic disease, and the possibility of producing preventive vaccine against these conditions merits serious consideration.
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PMID:Prospects of vaccines against cancer in man. 21 39

One hundred and sixty-eight patients with unresectable primary liver cancer were prospectively studied by members of the Eastern Cooperative Oncology Group. These patients were randomized to receive treatment with oral 5-Fluorouracil (5FU), oral 5-Fu plus Streptozotocin, oral 5-Fu plus Methyl-CCNU or Adriamycin. The single agent treatments (oral 5-Fu and Adriamycin) were associated with less gastrointestinal toxicity than were the oral 5-Fu treatment combinations. A total of 15 partial responses were reported. Adriamycin appears to be the most active agent and responsible for 9 of the 15 responses. No response was seen in any of the 48 patients randomized to oral 5-Fu alone. The survival associated with oral 5-Fu alone was significantly shorter than the survival time associated with the remaining 3 treatment programs among both North American and South African patients. A multivariate model of survival was formulated. Covariates of prognostic significance were treatment, initial performance status and sex. South African black patients had a shorter survival time than North American black patients. Excluding oral 5-Fu from consideration, prognostic variables appeared to dominate any differences between the remaining treatments under study.
Cancer 1978 Nov
PMID:Chemotherapy studies in primary liver cancer: a prospective randomized clinical trial. 21 18

Computed Tomography (CT) was introduced to detect lesions in 48 cases with various hepatobiliary disease. In 8 out of 11 cases with liver cell cancer, diagnosis were made by CT. A case was detected in early stage, the low density area was so small that it can be resected segmentally. In 7 out of 9 cases with metastatic liver cancer, multiple low densities were detected by C.T. Gallbladder cancers, which is known as diagnostic difficulty, were detected in five cases as low density in gallbladder area. CT has superiority to liver scintiscan, 1) CT can determine the tumor more exactly except for the diffuse type. 2) CT can be performed repeatedly without any risk and use of isotopic substances. 3) CT observes the transverse configuration of the organ, which could not be done in any conventional method.
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PMID:Computed tomography in hepatobiliary diseases. 21 86

Primary monolayer fetal and adult rat hepatocyte culture systems, which are being used to help analyze in vivo mechanisms controlling liver regeneration, proliferation, and differentiation are described. With results from animal studies of normal or genetically altered rats subjected to partial hepatectomy, to chemical infusions, or to specific dietary deficiency regimens, an apparently complex growth regulatory pattern has emerged. The data suggest a working hypothesis postulating interactions among hormone, nutritional, lipoprotein, and novel nucleotide factors at multiple regulatory sites. These findings may provide some conceptual and experimental basis for future research regarding the development of hepatic cancer, as it may arise spontaneously or from exposure to environmental carcinogens.
Natl Cancer Inst Monogr 1978 May
PMID:Hepatocyte growth control: in vitro approach to problems of liver regeneration and function. 21 65

Guanosine 3'5'-cyclic monophosphate (cGMP) in the plasma of normal persons and patients with lung or breast cancer and other kinds of neoplasma or other diseases was determined using radioimmunoassay. In comparison with normal persons, significant elevation occurred in the cGMP in the plasma of patients with various kinds of cancer or renal insufficiency. The average cGMP values in the plasma of eight normal persons, 16 patients with lung cancer, 16 patients with breast cancer, five patients with oesophagus cancer, three patients with liver cancer, three patients with stomach cancer, ten patients with renal insufficiency and two patients with myocardial infarction, were respectively 3.46, 9.05, 5.39, 5.42, 7.33, 11.66, 19.55, and 8.0 pmol per ml of plasma. There was no elevation in the cGMP in the plasma of the patients with other diseases studied.
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PMID:Guanosine 3', 5'-cyclic monophosphate level in plasma of patients with cancer and various diseases. 22 Nov 27

Primary hepatocellular carcinoma is a common disease in Africa, particularly in Mozambique, South Africa, Zambia, Kenya, etc. In Dodoma Region of Tanzania, the populace consumes large numbers of ground nuts which are believed to predispose to liver cancer. Of 939 clinically diagnosed malignancies in the Region during 1972-1976, 256 (27 percent) were primary hepatocellular carcinomas. An analysis of these findings is presented.
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PMID:Epidemiological study of carcinoma of liver in Dodoma region in Tanzania. 22 6

The value of the leucocyte adherence inhibition (LAI) test in the diagnosis of hepatocellular carcinoma (HCG) was investigated in 36 patients with this tumour. The sensitivity and specificity of the tube LAI test was assessed in 21 patients with HCC, 15 apparently healthy individuals, 9 patients with various forms of benign liver disease and 5 patients with non-hepatic neoplasms. In only 42% of the HCC patients tested was leucocyte adherence to glass reduced to a greater extent than in the healthy controls and in the patients with non-hepatic neoplasms, and the differences were not statistically significant. Moreover, positive results were obtained in 6/9 patients with benign hepatic disease. A further 15 patients were tested against extracts of HCC tissue using the haemacytometer LAI method. Of these, 53% gave positive results. In all, only 17/36 patients (47%) gave positive LAI responses. The test is thus of limited value in the diagnosis of HCC. The high false-negative result rate may be due either to abrogation of the immune response in HCC patients with large tumour burdens or to antigenic heterogeneity in HCC.
Br J Cancer 1979 Sep
PMID:Evaluation of leucocyte adherence inhibition in hepatocellular carcinoma. 22 91

The nature of nuclear proteins that are soluble in 8 M urea-50 mM phosphate, pH 7.6, was compared in rat liver and Morris hepatomas, Isoelectric focusing, using carrier ampholytes for a pH gradient of 3.5 to 10, indicated that with increasing growth rate of the hepatomas there was a progressive tendency for a decrease in nonhistone nuclear proteins with isoelectric points in the range 7.5 to 8.9 and an increase in the range 5.1 to 6.7. Studies on the influence of time on the pH gradient revealed that a nonuniform drift provided a better resolution of the pH range 7.5 to 8.9 at 7 hr than at 24 hr, while the latter time for electrofocusing gave an improved resolution of the pH range 5.1 to 6.7 Polyarcylamide gel electrophoresis in a urea-acetic acid system showed that 8 M urea-50 mM phosphate; pH 7.6 extracted a small part of the histones from nuclei of both liver and hepatomas. There was less extraction of histones from the hepatoma nuclei, especially in two rapidly growing hepatomas with the most notable difference being seen in the lysine-rich H1 histone. The results suggested that in addition to qualitative or quantitative changes in nonhistone nuclear proteins in liver cancer there are alterations in the binding of histones to chromatin.
Cancer Res 1975 Jul
PMID:Nuclear protein changes in rat hepatomas correlating with growth rate. 23 25


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