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Target Concepts:
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Query: UMLS:C0344329 (
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28,634
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
mDia is an actin nucleator and polymerization factor regulated by the small GTPase Rho and consists of three isoforms. Here, we found that mice lacking mDia1 and mDia3, two isoforms expressed in the brain, in combination (mDia-DKO mice) show impaired left-right limb coordination during locomotion and aberrant midline crossing of axons of corticospinal neurons and spinal cord interneurons. Given that mice lacking
Ephrin-B3
-EphA4 signaling show a similar impairment in locomotion, we examined whether mDia is involved in
Ephrin-B3
-EphA4 signaling for axon repulsion. In primary cultured neurons, mDia deficiency impairs growth cone
collapse
and axon retraction induced by chemo-repellants including EphA ligands. In mDia-DKO mice, the
Ephrin-B3
-expressing midline structure in the spinal cord is disrupted, and axons aberrantly cross the spinal cord midline preferentially through the region devoid of
Ephrin-B3
. Therefore, mDia plays multiple roles in the proper formation of the neural network in vivo.
...
PMID:EphA4-dependent axon retraction and midline localization of Ephrin-B3 are disrupted in the spinal cord of mice lacking mDia1 and mDia3 in combination. 2389 Feb 16
