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Query: UMLS:C0344329 (collapse)
 28,634 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An 11-year-old neutered male Yorkshire Terrier was presented to the Haemaru Referral Animal Hospital with a history of unresponsive tracheal collapse and an incidental finding of a lung nodule in the left caudal lung lobe on radiography. Thorough physical examination and imaging studies revealed no other masses. Cytologic examination of C-arm mobile fluoroscopy-guided fine-needle aspirates revealed numerous free nuclei and a low number of small round cells with moderate to abundant pale basophilic cytoplasm. Some cells contained indistinct basophilic granules in their cytoplasm, and extracellular pink material was noted. A caudal lung lobectomy was performed, and histologic evaluation of the mass revealed round to polygonal cells with abundant eosinophilic granular cytoplasm and round nuclei with mild anisokaryosis and 0-3 mitotic figures per high-power field. Cells were arranged in packets separated by fine fibrovascular stroma, suggestive of a pulmonary neuroendocrine neoplasm, specifically a carcinoma/carcinoid. The cells were immunoreactive for chromogranin A and neuron-specific enolase, and negative for cytokeratin, synaptophysin, calcitonin, thyroglobulin, parathyroid hormone, CD79a, light lambda, and vimentin. With these findings the tumor was diagnosed as a primary lung carcinoid. Eleven months after resection, there was no evidence of tumor regrowth or metastasis. The absence of necrosis, few mitotic figures, minimal pleomorphism, and benign behavior of this tumor resembled those of a typical carcinoid in humans.
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PMID:Cytologic and immunohistochemical characterization of a lung carcinoid in a dog. 1853 28

: A 14-year-old male Labrador Retriever was presented for lethargy and collapse. On physical examination, numerous abnormalities were found, including a large ventral neck mass (100 cm(3)) in the area of the thyroid gland. Fine-needle aspirates revealed 2 apparent populations of cells: one suspected to be a well-differentiated thyroid carcinoma, and the other consisting of large pleomorphic to spindloid cells suggestive of sarcoma. Two days later, the dog died at home. A full necropsy was not performed, but examination of the head and neck revealed a well-encapsulated mass adjacent to the cranial trachea and larynx. A section of the mass was evaluated histologically and a diagnosis of anaplastic thyroid carcinoma was made. Immunohistochemical evaluation with antibodies to thyroglobulin, cytokeratin, and vimentin confirmed distinct populations of malignant epithelial and malignant mesenchymal cells, and the diagnosis was amended to thyroid carcinosarcoma. Thyroid carcinosarcoma is a rare neoplasm in dogs in which the cell type comprising the mesenchymal component can vary. Immunochemistry to demonstrate the 2 cell types may be necessary to differentiate thyroid carcinosarcoma from anaplastic thyroid carcinoma.
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PMID:What is your diagnosis? Ventral neck mass in a dog. 1905 83

Biopsy specimens from 5 papillary thyroid carcinomas (PC), 2 lymph node metastases (LM) from PC, 3 colloid goitres (CG) and 7 normal (N) thyroid tissue were maintained as three-dimensional structures in agar overlay culture for up to 6 weeks. This organ culture method provides a system that maintains the cellular complexity present in the original tissue, including the stromal elements. Organotypic cultures with a well defined surface architecture were obtained. Follicles present in the spheroids maintained a polarized epithelial cell layer. Immunohistochemical staining showed thyroglobulin expression in most spheroids after two weeks of culture. Proliferating cells were also observed after the same time period evaluated by proliferation cell nuclear antigen (PCNA) immunostaining. The spheroids obtained from one of the papillary carcinomas and the corresponding lymph node metastasis increased in volume size during the first three weeks of culture while in the other cases volume decreased. The proportion of connective tissue increased in most of the spheroids during the culture period and a partial collapse of follicles was observed in parallel. Papillary structures were observed in spheroids from papillary carcinomas and lymph node metastases. Our data indicate that viable organotypic spheroid cultures can be obtained and propagated in vitro from thyroid tissue. Such a system has a potential use for studying normal biological functions of thyroid tissue in vitro and this method may be of special value in studying mechanisms of invasive growth as well as effects of therapy on normal and neoplastic tissue taken from individual patients.
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PMID:Primary organ-culture of nonneoplastic and neoplastic thyroid-tissue as multicellular spheroids. 2155 42

A three-year-old, female neutered, Dobermann pinscher was presented for investigation of lethargy, episodic collapse, ataxia and myxoedema. Primary hypothyroidism and primary cortisol-deficient hypoadrenocorticism were diagnosed based on history, physical examination and compatible hormonal analysis. Increased serum concentrations of thyroglobulin autoantibodies and 21-hydroxylase autoantibodies indicated an immune-mediated aetiology. The case was complicated by lymphadenopathy with hand-mirror lymphocytes, classically identified in lymphoma. A polymerase chain reaction test for antigen receptor rearrangement indicated polyclonality and therefore reactive lymphadenopathy. The dog's clinical signs resolved following introduction of levothyroxine and prednisolone. Prioritising the problem-based approach in this case facilitated the diagnosis of hypoadrenocorticism in addition to hypothyroidism due to the persistence of clinical signs despite thyroxine replacement. Importantly, atypical adrenal gland dysfunction was not misinterpreted as inadequate therapeutic response to thyroxine supplementation. The observation that polyglandular endocrinopathy type II can occur in dogs suggests that in dogs with a suboptimal response to treatment for hypothyroidism or hypoadrenocorticism comorbid endocrinopathies should be investigated.
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PMID:Polyglandular endocrinopathy type II (Schmidt's syndrome) in a Dobermann pinscher. 2748 17