Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0344329 (
collapse
)
28,634
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The regulation of the acid-base balance in cells is essential for proper cellular homeostasis. Disturbed acid-base balance directly affects cellular physiology, which often results in various pathological conditions. In every living organism, the protein family of carbonic anhydrases regulate a broad variety of homeostatic processes. Here we describe the identification, mapping and cloning of a zebrafish carbonic anhydrase 5 (ca5) mutation,
collapse
of fins (cof), which causes initially a
collapse
of the medial fins followed by necrosis and rapid degeneration of the embryo. These phenotypical characteristics can be mimicked in wild-type embryos by acetazolamide treatment, suggesting that
CA5
activity in zebrafish is essential for a proper development. In addition we show that
CA5
regulates acid-base balance during embryonic development, since lowering the pH can compensate for the loss of
CA5
activity. Identification of selective modulators of
CA5
activity could have a major impact on the development of new therapeutics involved in the treatment of a variety of disorders.
...
PMID:Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish. 2274 34
