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Query: UMLS:C0344329 (collapse)
 28,634 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Results on the efficiency and toxicity of arecoline hydrobromide during the first 11 years of the hydatid limitation program in Tasmania are presented. A satisfactory mucous purge was obtained from about 80% of dogs when arecoline was used at 3.25 mg/kg and from about 75% when the dose rate was reduced to 1.62 mg/kg of body weight. Arecoline is considered to have a low efficiency in detecting tapeworm infection in individual dogs, but is valuable as a diagnostic aid in groups of dogs. Toxicity was seen as acute cardiac collapse in about 5 dogs per 1000 dosed. Deaths followed in 1 dog in about 9,500.
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PMID:The toxicity and efficiency of arecoline hydrobromide in the Tasmanian hydatid control program. 68 77

In rabbits, i.v. delta9-tetrahydrocannabinol (delta9-THC) at 0.5 mg/kg was challenged with i.v. arecoline (0.025 mg/kg), nicotine (0.02 mg/kg) or physostigmine (PHYSO, 0.05 mg/kg), and observations were made on quantified EEG and behavior. The cholinomimetics effectively reversed the cortical and hippocampal EEG alterations induced by delta9-THC. Arecoline and PHYSO temporarily reversed the behavioral-sedative effects of delta9-THC whereas the combination of delta9-THC with nicotine produced behavioral collapse preceded by behavioral disturbance.
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PMID:The interaction of delta9-tetrahydrocannabinol with cholinomimetic drugs in an agonist-antagonist paradigm. 95 40

Echinococcosis is a re-emerging zoonotic disease in Kyrgyzstan, and the incidence of human infection has increased substantially since the collapse of the Soviet Union in 1991. Domestic dogs are hosts of Echinococcus spp. and play an important role in the transmission of these parasites. The demography, ecology and behaviour of dogs are therefore relevant in studying Echinococcus spp. transmission. Dog demographics, roles of dogs, dog movements and faecal environmental contamination were assessed in four rural communities in the Alay Valley, southern Kyrgyzstan. Arecoline purge data revealed for the first time that E. granulosus, E. canadensis and E. multilocularis were present in domestic dogs in the Alay Valley. Surveys revealed that many households had dogs and that dogs played various roles in the communities, as pets, guard dogs or sheep dogs. Almost all dogs were free to roam, and GPS data revealed that many moved outside their communities, thus being able to scavenge offal and consume rodents. Faecal environmental contamination was high, presenting a significant infection risk to the local communities.
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PMID:Dog ownership, dog behaviour and transmission of Echinococcus spp. in the Alay Valley, southern Kyrgyzstan. 2398 26