Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344329 (collapse)
 28,634 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

From 1999, at the Orthopaedic Clinic of the University of Siena, 56 patients were treated with the compression hip nail-plate system, a new synthesis device for the treatment of peritrochanteric fractures. The system consists in a new dynamic cephalic screw that could be combined with a plate or a femoral nail. The dynamic cephalic screw of the BCM system has a limited sliding method, impeding excursion greater than 10 mm and preventing excessive collapse of the fracture fragments that can evolve into a shortening of the limb. The canulated nail has a diameter of only 9 mm, which permits insertion into the shaft canal without reaming. The possibility of the double combination of the screw with a plate or with an intramedullary nail permits the surgeon to have a double solution with a single instrument at hand, and offers the opportunity of changing the choice of synthesis method to implant even during surgery.
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PMID:Preliminary experience with a new osteosynthesis device for intertrochanteric fractures. 1223 72

We report on assembly and stimuli-response behavior of layer-by-layer (LbL) films of pH- and temperature-responsive cationic diblock copolymer micelles (BCMs) of poly(2-(dimethylamino)ethyl methacrylate)-block-poly(N-isopropylacrylamide) (PDMA-b-PNIPAM) and a linear polyanion polystyrene sulfonate (PSS). As a function of solution pH at temperatures above lower critical solution temperature (LCST) of PNIPAM, PDMA-b-PNIPAM micelles have been demonstrated earlier to exhibit an abrupt change in micellar aggregation number and hydrodynamic size between larger and smaller BCMs (LBCMs and SBCMs, respectively). Here, LBCMs or SBCMs were included within LbL films through self-assembly with a polyanion, and film pH and temperature responses were studied using ellipsometry and atomic force microscopy (AFM). Both types of micelle preserved their micellar morphology when adsorbed at the surface of oxidized silicon wafers coated with PSS-terminated precursor layer at a constant pH. Response of adsorbed BCMs to temperature and pH variations was strongly dependent on whether or not BCMs were coated with the PSS layer. While monolayers of LBCMs lost their original dry morphology in response to pH or temperature variations, depositing a PSS layer atop LBCMs inhibited such irreversible restructuring. As a result of wrapping around and strong binding of PSS chains with LBCM micelles, BCM/PSS assemblies preserved their original dry state morphology despite the application of pH and temperature triggers. However, the wet-state film response to pH and temperature stimuli was drastically different. Swelling of BCM/PSS multilayers was strongly affected by temperature but was almost independent of pH due to neutralization of BCM PDMA's coronal charge with PSS. Cycling the temperature below and above PNIPAM's LCST caused PNIPAM chains within BCM cores to swell or collapse, resulting in reversible swelling transitions in the entire BCM/PSS assemblies. Temperature-controlled switching between the hydrophobic and hydrophilic state of assembled micellar cores was also used to regulate the release of a micelle-loaded hydrophobic pyrene dye, whose release rate increased at temperatures below PNIPAM's LCST.
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PMID:Polyelectrolyte multilayers of diblock copolymer micelles with temperature-responsive cores. 2113 98