Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344329 (collapse)
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The mixing behavior of 1-(perfluorobutyl)undecanoic acid-pentadecanoic acid (C15), 1-(perfluorohexyl)undecanoic acid-heptadecanoic acid (C17), and 1-(perfluorooctyl) undecanoic acid-nonadecanoic acid (C19) mixtures was investigated at the air-water interface. The compression isotherms of the fluorocarbon acid-hydrocarbon acid mixtures were recorded at various compositions on hydrochloric acid (pH 1.9, 37+/-2 degrees C) as a subphase. The phase transition, limiting molecular area, area at collapse pressure, and collapse pressure were determined for all pi-A isotherms. The mixing behavior was assessed by analyzing the concentration dependence of the average molecular area at constant film pressure (area/mole fraction or A-X diagram) and the concentration dependence of the phase transition, where possible. All three acid mixtures show a negative deviation from ideal behavior at surface pressures between 5 and 20 mN/m, which is indicative of an attractive interaction of both compounds in the mixed monolayer at the air-water interface. The miscibility apparently decreases with increasing chain length of the carboxylic acids (C15>C17>C19).
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PMID:Mixing of partially fluorinated carboxylic acids with their hydrocarbon analogs at the air-water interface. 1629 Jun 12

A random copolymer (p(A/MaU)) of sodium 2-(acrylamido)-2-methylpropanesulfonate (AMPS) and sodium 11-methacrylamidoundecanate (MaU) was prepared via conventional radical polymerization, which formed a unimer micelle under acidic conditions due to intramolecular hydrophobic interactions between the pendant undecanoic acid groups. Under basic conditions, unimer micelles were opened up to an expanded chain conformation by electrostatic repulsion between the pendant sulfonate and undecanoate anions. A cationic diblock copolymer (P163M99) consisting of poly(3-(methacrylamido)propyl)trimethylammonium chloride (PMAPTAC) and hydrophilic polybetaine, 2-(methacryloyloxy)ethylphosphorylcholine (MPC), blocks was prepared via controlled radical polymerization. Mixing of p(A/MaU) and P163M99 in 0.1 M aqueous NaCl under acidic conditions resulted in the formation of spherical polyion complex (PIC) micelles and vesicles, depending on polymer concentration before mixing. Shapes of the PIC micelles and vesicles changed under basic conditions due to collapse of the charge balance between p(A/MaU) and P163M99. The PIC vesicles can incorporate nonionic hydrophilic guest molecules, and the PIC micelles and vesicles can accept hydrophobic guest molecules in the hydrophobic core formed from p(A/MaU).
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PMID:Formation of Polyion Complex (PIC) Micelles and Vesicles with Anionic pH-Responsive Unimer Micelles and Cationic Diblock Copolymers in Water. 2704 89