Gene/Protein Disease Symptom Drug Enzyme Compound
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 28,634 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In infants with transposition of the great arteries (TGA) tracheobronchial obstruction may occur as a result of compression by a dilated posterior pulmonary artery, especially if there is a large interventricular septal defect with its attendant large pulmonary blood flow and high pressure. Banding of the pulmonary artery may give temporary relief. A patient with TGA had collapse of the left lung at 2 months of age, following atrial septectomy. Bronchoscopy and bronchography revealed extrinsic compression of the left main bronchus. Banding of the pulmonary artery at 6 months of age relieved the respiratory distress. At 8 years of age atelectasis of the left lung recurred following a Mustard procedure. Two additional procedures were attempted to decrease the pressure of the pulmonary artery on the bronchus but these were unsuccessful. At age 9 years, pneumonectomy, her sixth thoracotomy, was performed as a final attempt to relieve the respiratory problem caused by persistent atelectasis. She is now 17 years of age and has remained asymptomatic during the last 8 years.
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PMID:Pneumonectomy for intractable left bronchial compression in d-transposition of the great arteries. 76 61

Pneumothorax develops when extraalveolar air ruptures into the pleural space with partial or complete collapse of the affected lung. Pneumothorax can occur at any time during the newborn period, but it usually appears as a complication of some other respiratory problem. The purpose of this study is to known the incidence of pneumothorax due to the respiratory difficulties. The materials were taken from 2368 neonates suffering from respiratory difficulties, out of 7445 neonates born in Cipto Mangunkusumo General Hospital in 1987 and 1988. All these babies were put on radiological examination. Among those 10 babies were diagnosed as pneumothorax. It occurred as a complication of severe asphyxia (due to over vigorous initial resuscitation), and its incidence was 0.09%, that of respiratory distress syndrome (2.13%), bronchopneumonia (6.25%) and aspiration pneumonia (2.8%). The overall incidence of pneumothorax in the newborn with respiratory difficulties was 0.42% and the mortality 20%.
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PMID:Pneumothorax in the newborn with respiratory difficulties. 207 21

Exercise-inducible laryngeal obstruction (EILO) has been recognized as a not rare respiratory problem in youth practicing sports. The aim of the study was to test the mechanosensitivity of the larynx, and to identify the factors affecting it in a group of youth with proven EILO. Laryngeal sensory testing was performed in 54 adolescents and young adults with EILO. Laryngeal mucosal alterations were assessed according to the Reflux Finding Score (RFS). The data concerning diseases possibly affecting the upper airway, findings of previously performed flexible videolaryngoscopy during exercise, and RFS score were compared between the participants with laryngeal hyposensitivity and those with normal sensitivity. The participants with isolated vocal folds' adduction during an EILO attack were compared with those who demonstrated supraglottis collapse. Testing revealed an increased threshold for mechanical stimuli in 81.5% of participants. Among participants with hyposensitivity, there were significantly more participants with dysphagia during EILO attacks than among the participants with normal laryngeal sensitivity. The hyposensitivity group had a significantly higher RFS score compared with the other group. Isolated vocal folds' approximation was only observed in 11.9% of participants. These participants were younger and had asthma more frequently compared with the others. Only 16.9% of participants with EILO did not state symptoms related to gastroesophageal reflux. The decreased mechanosensitivity was detected in the majority of participants, suggesting that laryngopharyngeal reflux can be an important etiological factor. The problem of breathing difficulties during sport activities in youth can also be associated with the disproportionate growth of the respiratory tract.
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PMID:Laryngeal sensitivity testing in youth with exercise-inducible laryngeal obstruction. 2822 37