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 28,634 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Records on 1,297 people with witnessed out-of-hospital cardiac arrest, caused by heart disease and treated by both emergency medical technicians (EMTs) and paramedics, were examined to determine whether or not early cardiopulmonary resuscitation (CPR) initiated by bystanders independently improved survival. Bystanders initiated CPR for 579 patients (bystander CPR); for the remaining 718 patients, CPR was delayed until the arrival of EMTs (delayed CPR). Survival was significantly better (P less than 0.05) in the bystander-CPR group (32%) than in the delayed-CPR group (22%). Multivariate analysis revealed that the superior survival in the bystander-CPR group was due almost entirely to the much earlier initiation of CPR (1.9 minutes for the Bystander-CPR group and 5.7 minutes for the delayed-CPR group; P less than 0.001). There were significantly more people with ventricular fibrillation (VF) in the bystander-CPR group (80%) than in the delayed-CPR group (68%); and, for people in VF, the survival rate was significantly better if they had received bystander-CPR (37% versus 29%). The authors conclude that early initiation of CPR by bystanders significantly improves survival from out-of-hospital cardiac arrest, and they suggest that it may do so by prolonging the duration of VF after collapse and by increasing cardiac susceptibility to defibrillation. The benefit of this early CPR, however, appears to exist within a rather narrow window of effectiveness. It must be started within 4-6 minutes from the time of collapse and must be followed within 10-12 minutes of the collapse by advanced life support in order to be effective.
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PMID:Survival of out-of-hospital cardiac arrest with early initiation of cardiopulmonary resuscitation. 397 Jul 66

Studies have shown that over 50% of cardiovascular deaths occur before hospitalization. A major factor associated with survival in cases of out-of-hospital cardiac arrest is the time from cardiovascular collapse to the initiation of cardiopulmonary resuscitation (CPR) or "downtime." The purpose of this study was to determine whether blood lactate levels could be used to predict downtime in the canine cardiac arrest model. Femoral arterial and Swan-Ganz catheters were placed in 22 mongrel dogs, and ventricular fibrillation was electrically induced. The dogs remained in ventricular fibrillation without ventilation for 5, 10, 15, 30, or 60 minutes. After the predetermined fibrillation time, a left anterolateral thoracotomy was performed, and open-chest cardiac massage was begun. Arterial and mixed venous lactate levels were determined for every 5 minutes during 30 minutes of cardiopulmonary resuscitation. The correlation coefficient between the mixed venous and arterial lactate levels was 0.96 or greater during all stages of resuscitation. Peak serum lactate level increased linearly in relation to downtime. The increase in lactate level was not evident until after CPR was begun, and it remained at peak levels or decreased insignificantly, despite optimal open-chest CPR. Linear regression analysis revealed that 84% of the variability in serum lactate levels could be explained by downtime differences. In this model, blood lactate level is a reliable and objective measure of downtime and may be a useful indicator of the adequacy of CPR if levels decrease or remain stable. The clinical implications of this study lie with the use of blood lactate levels in the emergency department to guide the aggressiveness of resuscitative efforts.
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PMID:Lactic acidosis as a predictor of downtime during cardiopulmonary arrest in dogs. 397 Jul 67

Hospital mortality was examined in all patients successfully resuscitated from a witnessed out-of-hospital cardiac arrest due to ventricular fibrillation over a 1-yr period. Variables independently predictive of hospital mortality were a history of congestive heart failure before cardiac arrest, the time between collapse and initiation of CPR, and the time between collapse and restoration of circulation. The latter time was not related to either patient age or clinical history. Thus, hospital mortality was predetermined by prehospital factors, some of which can be changed.
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PMID:Predictors of hospital mortality after out-of-hospital cardiopulmonary resuscitation. 405 42

On the assumption that increased urinary lysozyme concentration (;lysozymuria') indicates tubular proteinuria and therefore impaired tubular function, urinary lysozyme has been estimated in acute disorders where transient disturbances of renal function might be expected, in cases diagnosed clinically as extrarenal uraemia, and in a few examples of acute renal disease. Reversible lysozymuria occurred with hypokalaemia, postoperative ;collapse', electrolyte depletion, severe extrarenal infection, acute pyelonephritis, the nephrotic syndrome, after a few apparently uncomplicated surgical operations, and very transiently after ventricular fibrillation abolished by DC shock. There was no lysozymuria with severe uraemic heart failure, aspirin and paracetamol poisoning, or severe jaundice, nor in two cases of acute glomerulonephritis. Although lysozymuria may occasionally be useful in the clinical diagnosis of acutely disordered renal function, the results suggest that its value is limited; on the other hand, they have provided information on renal pathophysiology in acute disease.
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PMID:Lysozymuria and acute disorders of renal function. 470 97

Survival after out-of-hospital cardiac arrest was studied in a suburban community (population 304000) before and after addition of paramedic services. During period 1 emergency medical technicians provided basic emergency care (cardiopulmonary resuscitation at the scene of collapse and during the journey to hospital). In period 2 additional care was given at the scene of collapse by paramedics capable of advanced emergency care (defibrillation, endotracheal intubation, drugs). During the 3-yr study 585 patients with cardiac arrest caused by heart disease received prehospital emergency resuscitation. Paramedic services improved the rate of live admission to the coronary-care or intensive-care unit from 19% to 34% (p less than 0.001) and the rate of discharge from 7% to 17% (p less than 0.01). The mean time from collapse to delivery of advanced emergency care was 27.5 min during period 1 with technician services, and 7.7 min during period 2 with paramedic services. Ventricular fibrillation caused cardiac arrest in nearly all patients who survived; it occurred in 91 of the 160 (57%) patients during period 1 whose rhythms were determined and in 192 of the 343 (56%) patients during period 2. The decreased time from collapse to delivery of advanced emergency care accounted for the improved survival with paramedic services.
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PMID:Out-of-hospital cardiac arrest: improved survival with paramedic services. 610 90

A retrospective review was undertaken to determine the influence of the St John Ambulance life support units on the the incidence of sudden cardiac death during a 12 month period in Auckland. In 65 instances subjects who collapsed with either ventricular fibrillation or cardiac arrest were resuscitated and transported alive to a hospital accident and emergency department in the Auckland area. Twenty patients died within 24 hours of admission and a further 14 died in hospital. There were seven late deaths and 24 survivors (37%). Ten patients are asymptomatic and the remainder are troubled by angina or breathlessness. Only three of the surviving patients have suffered severe cerebral damage as a result of their collapse.
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PMID:Sudden cardiac death: results of resuscitation begun outside hospital. 634 35

Ventricular fibrillation, an abnormal cardiac rhythm, occurs in at least two-thirds of the 400,000 people who die out of the hospital from sudden cardiac arrest. This rhythm can be treated successfully by electric countershock, a procedure known as defibrillation. The survival rate following such cardiac arrest is directly related to the rapidity of response; the shorter the time from collapse to defibrillation, the more patients will survive. There are two basic options to shorten the time from collapse to defibrillatory shock. The first is to upgrade the emergency medical system. The second is to provide spouses and family members of potential cardiac arrest patients with automatic home defibrillators. This article considers the effectiveness of the second option, home defibrillation, compared with that of an equally costly upgrade in existing emergency medical service systems. The comparisons depend on the existing level of emergency medical service system, the cost of the home defibrillator, and the rate at which a home defibrillator would be used appropriately. The comparisons suggest that in many circumstances home defibrillation is an appropriate option to be considered.
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PMID:The potential use of automatic defibrillators in the home for management of cardiac arrest. 651 18

Clinical proton NMR imaging uses magnetic field strengths in the range 0.1 to 0.5 T. In addition to the large static magnetic field, patients are exposed to magnetic field gradients during imaging and under extreme conditions, such as power failure or quenching, the field may collapse precipitously. A potential source of hazard to patients under these conditions is the induction of thoracic currents which may trigger ventricular fibrillation. In the present experiments, a 0.16 T resistive magnet with a time constant of 60 ms, powered by a programmable power supply, was used to examine any possible effects of static and changing magnetic field on the ECG and arterial blood pressure of anesthetized rats and guinea pigs. Animals were exposed to the following field conditions: static fields of 0.16 T; sine, triangular, and square wave modulated fields from 0.1 to 2 Hz; rapid field switches in excess of 2.0 T/s for 25 ms timed to occur at different stages of the cardiac cycle, including the vulnerable period during ventricular repolarization; and AC fields of 50 Hz. No change was observed in the blood pressure, heart rate, or ECG under any of the field conditions examined.
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PMID:Potential hazards of NMR imaging. No evidence of the possible effects of static and changing magnetic fields on cardiac function of the rat and guinea pig. 653 Sep 23

We have compared the effectiveness of two different mobile coronary care systems with regard to mortality from cardiac arrest (CA) outside hospital in Gothenburg, Sweden. In period 1, the mobile coronary care unit (MCCU) was part of a randomized study of the effect of an MCCU versus standard ambulances on early mortality from ischaemic heart disease. The MCCU was single, hospital based and manned by two CCU nurses and two ambulance drivers. The organization ran on workdays 08.00 a.m. to 17.00 p.m. from October, 1973 to May, 1978, corresponding to twelve months of effective time. One-year data for the MCCU have been calculated by extrapolating to a 100% allocation to the MCCU. In period 2, from November, 1980, through December, 1981, also corresponding to twelve months of effective time, the system was reorganized to a mobile intensive care unit (MICU) manned by paramedics 24 h all days of the week, and part of the time by CCU nurses. The MICU was dispatched to all suspected emergencies and the treatment capacity was defibrillation, endotracheal intubation and, part of the time, drugs. Simultaneously with the MICU, the nearest standard ambulance was dispatched and the first crew to arrive started cardiopulmonary resuscitation (CPR). Comparing the extrapolated data from period 1 with the exact data from period 2, there was an increase in period 2 of dispatches to subjects in CA due to heart disease from 59 to 181. The retrieval of subjects in ventricular fibrillation (VF) increased from 20 to 87 as a result of reduced delay times from the collapse to alarm, start of CPR and defibrillation.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Resuscitation of patients in cardiac arrest outside hospital. Comparison of two different organizations of mobile coronary care in one community. 670 2

Laboratory dogs are used to demonstrate and practice cardiopulmonary resuscitation (CPR) procedures. Cardiovascular collapse, cardiac arrest, and ventricular fibrillation are produced in anesthesized dogs and then managed by the student. The laboratory exercise focuses and emphasizes CPR material taught in the classroom and on mannequins. With the current emphasis on CPR training and certification, we recommend the concept to the dental profession as an added dimension in teaching CPR.
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PMID:Cardiopulmonary resuscitation: a teaching aid. 692 3


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