Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344329 (collapse)
 28,634 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Psychiatric evaluation teams used observations of family interaction and psychoanalytically oriented individual interviews to study the psychological aftereffects of the 1972 Buffalo Creek disaster, a tidal wave of sludge and black water released by the collapse of a slag waste dam. Traumatic neurotic reactions were found in 80% of the survivors. Underlying the clinical picture were unresolved grief, survivor shame, and feelings of impotent rage and hopelessness. These clinical findings had persisted for the two years since the flood, and a definite symptom complex labeled the "Buffalo Creek syndrome" was pervasive. The methods used by the survivors to cope with the overwhelming impact of the disaster--first-order defenses, undoing, psychological conservatism, and dehumanization--actually preserved their symptoms and caused disabling character changes.
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PMID:Disaster at Buffalo Creek. Family and character change at Buffalo Creek. 125 39

Most psychoanalytic writers believe that both asthma and sexual impotence depend on fixations at the early stages of the Oedipus complex. Through psychoanalytic study of patients with both disorders, the author believes that this problem may be considered from another angle whereby the fixation of sexual impotence is situated at the early stages of the Oedipus complex, while asthma depends on fixations at the level of the breast although its character is also triangular. It is the author's opinion that in studying the psycho-pathogenesis of these afflictions it is important to distinguish between basic and defensive phantasies, since it is the former which reveals the level of object relations where the malady is situated. Defensive phantasies include, owing to regressive and progressive movements, objects and defences from other levels and therefore cannot be used for the investigation of levels of fixation. In the cases presented, the aim of the psychosomatic symptom is, in asthma, to avoid the collapse of the self while, in impotence, it is to avoid castration anxieties, when the introjected object does not provide sufficient cohesion to the self or is experienced as persecutory. At first the patient uses manic defences but should these fail, further defences are resorted to (contraction of the bronchioles in asthma and inhibition in sexual impotence), and these give rise to the psychosomatic symptom.
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PMID:Fixation of asthma and sexual impotence at different pregenital stages. 887 36

To investigate the outcome of our management of patients with giant cell tumour of the sacrum and draw lessons from this. A retrospective review of medical records and scans for all patients treated at our unit over the past 20 years with a giant cell tumour of the sacrum. Of the 517 patients treated at our unit for giant cell tumour over the past 20 years, only 9 (1.7%) had a giant cell tumour in the sacrum. Six were female, three male with a mean age of 34 (range 15-52). All, but two tumours involved the entire sacrum and there was only one purely distal to S3. The mean size was 10 cm and the most common symptom was back or buttock pain. Five had abnormal neurology at diagnosis, but only one presented with cauda equina syndrome. The first four patients were treated by curettage alone, but two patients had intraoperative cardiac arrests and although both survived all subsequent curettages were preceded by embolisation of the feeding vessels. Of the seven patients who had curettage, three developed local recurrence, but all were controlled with a combination of further embolisation, surgery or radiotherapy. One patient elected for treatment with radiotherapy and another had excision of the tumour distal to S3. All the patients are alive and only two patients have worse neurology than at presentation, one being impotent and one with stress incontinence. Three patients required spinopelvic fusion for sacral collapse. All patients are mobile and active at a follow-up between 2 and 21 years. Giant cell tumour of the sacrum can be controlled with conservative surgery rather than subtotal sacrectomy. The excision of small distal tumours is the preferred option, but for larger and more extensive tumours conservative management may well avoid morbidity whilst still controlling the tumour. Embolisation and curettage are the preferred first option with radiotherapy as a possible adjunct. Spinopelvic fusion may be needed when the sacrum collapses.
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PMID:Giant cell tumour of the sacrum: a suggested algorithm for treatment. 2007 78