Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.01 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 1789
opioid receptor 1096
ASA 450
beta-endorphin 444
Mol 249
substance P 236
GABA 229
PCA 221
She 219
oxytocin 209
dynorphin 178
mu opioid receptor 159
NMDA receptor 155
CO2 155
cholecystokinin 138
5-hydroxytryptamine 125
OFQ 122
CB1 116
cannabinoid receptor 104
calcitonin 102
COX-2 100
MRI 99
T10 96
calcium channel 95
Pol 93
cytokine 91
ACTH 88
insulin 85
Leu5 81
cyclooxygenase 79
CSF 78
neurotensin 78
kappa opioid receptor 73
delta opioid receptor 73
TRPV1 71
hemoglobin 68
T12 68
cage 66
Met 66
gut 65
vasopressin 64
Met-enkephalin 62
prolactin 62
nitric oxide synthase 61
CCK 60
CB2 60
bradykinin 59
neutral endopeptidase 58
Rec 57
rat) 57
reserved 57
IL-6 56
ANOVA 56
cyclooxygenase-2 56
ATP 55
somatostatin 54
Gen 53
THC 52
fatty acid amide hydrolase 50
TNF 49
dilute 48
DBA 48
arrestin 46
5-HT1A 46
PAG 45
nicotinic acetylcholine receptor 44
COX-1 44
OPRM1 44
Leu-enkephalin 44
tumor necrosis factor 43
corticotropin-releasing factor 41
ORL1 41
axonal 40
AMP 38
albumin 38
c-fos 38
MIF 37
HT3 37
TLR4 36
T11 36
nerve growth factor 36
tap 36
transient receptor potential vanilloid 1 35
growth hormone 35
sodium channel 34
WIN 34
ACS 34
adenylyl cyclase 34
olfactory 33
lipopolysaccharide 33
MAC 33
p38 33
G protein-coupled receptor 32
orexin 32
MOR-1 32
collagen 32
CYP2D6 31
ARC 31
P-glycoprotein 31
mouse) 31
5-HT3 receptor 31
MAP 30
muscarinic receptor 30
adenylate cyclase 29
GABA(A) receptor 29
KOR 29
MAPK 29
nociceptin receptor 29
cytochrome P450 28
interleukin-6 28
ERK 28
NMR 27
angiotensin II 27
Neuropeptide FF 26
hole 26
DRG 25
MOP 25
Hip 25
CD1 25
C-reactive protein 25
acetylcholinesterase 25
IL-1 25
proenkephalin 24
brain-derived neurotrophic factor 24
IL-10 24
hyaluronidase 24
SCH 24
ERK1 23
adrenocorticotropic hormone 23
COX 23
glial fibrillary acidic protein 22
proopiomelanocortin 22
renin 22
aminopeptidase 22
NK1 21
ionotropic 21
SNS 21
peptidase 20
monoacylglycerol lipase 20
G-protein-coupled receptor 20
PKC 20
glucagon 19
San 19
TRPA1 19
arginine vasopressin 19
serotonin receptor 19
peroxidase 19
fibrinogen 19
TRPM8 19
polypeptide 19
NHS 19
metabotropic glutamate receptor 19
5-HT receptor 19
5-HT2A 18
CA1 18
CCK-B 18
short form 18
BIS 18
calmodulin 18
mast cell 18
more...
Disease
depression 1651
chronic pain 1307
cancer 913
pruritus 559
cold 478
addiction 297
hypertension 286
tumor 239
PCA 221
osteoarthritis 191
physical dependence 152
diabetes 151
amnesia 149
delirium 142
catalepsy 141
ischemia 131
Frey 123
arthritis 120
stroke 119
Thoracic 118
Best 114
SEM 113
neuropathy 113
hernia 111
fits 111
ileus 110
pneumothorax 108
obesity 108
metastases 103
sepsis 99
abortion 96
sepsis 92
migraine 86
sickle cell disease 85
pneumonia 84
breast cancer 83
rheumatoid arthritis 82
uterus 81
myocardial infarction 77
inguinal hernia 76
fibromyalgia 75
epilepsy 71
cognitive impairment 69
myocardial ischemia 67
deep vein thrombosis 66
aggression 64
confusion 64
preeclampsia 63
carcinoma 61
scoliosis 60
renal failure 60
respiratory failure 59
postherpetic neuralgia 58
osteoporosis 55
gallstones 55
pertussis 52
West 52
regional pain syndrome 50
THC 49
compartment syndrome 48
drug addiction 48
DBA 48
heart disease 48
hallucinations 48
anemia 47
pancreatitis 47
peripheral neuropathy 46
diabetic neuropathy 46
coma 46
coagulopathy 45
bone metastases 45
Parkinson's disease 44
acute pancreatitis 44
prolapse 44
asthma 44
chronic obstructive pulmonary disease 42
mental illness 42
phantom limb pain 41
emphysema 41
drug abuse 41
trigeminal neuralgia 41
prostate cancer 41
lung cancer 40
decubitus 40
cataract 40
multiple sclerosis 40
HIV 40
dysphoria 39
Horner's syndrome 39
Opiates 39
irritable bowel syndrome 38
ureter 38
paraplegia 38
obstructive sleep apnea 38
acute myocardial infarction 38
schizophrenia 37
neuroblastoma 37
pulmonary embolism 37
NAME 37
akinesia 36
heart failure 36
infectious diseases 36
bone cancer 35
Cannabis 35
dystocia 34
meningitis 34
pulmonary hypertension 33
incontinence 33
AIDS 33
MAC 33
cardiomyopathy 32
disinhibition 32
peritonitis 32
Evans 32
hyperglycemia 32
Alzheimer's disease 32
chronic pancreatitis 32
posttraumatic stress disorder 32
encephalopathy 31
psychosis 30
thrombocytopenia 30
psychological stress 30
neurological disease 29
congestive heart failure 29
substance abuse 29
herpes zoster 28
bowel obstruction 28
renal impairment 28
dementia 28
renal disease 28
coronary artery disease 28
urolithiasis 27
colorectal cancer 27
memory impairment 26
cardiovascular disease 26
sleep apnea 26
xerostomia 26
lung disease 25
Blocking 25
rash 25
SCH 24
bronchospasm 24
malnutrition 24
adenocarcinoma 24
Neuromuscular blockade 24
tumor growth 24
myasthenia gravis 24
vagina 23
liver disease 23
celiac disease 23
dysphagia 23
alcoholism 23
strabismus 23
pancreatic cancer 23
Toxic epidermal necrolysis 23
cancer recurrence 22
varices 22
emotional distress 22
chronic renal failure 22
acute appendicitis 22
more...
Symptom
analgesia 28200
pain 14242
anesthesia 6982
nausea 868
acute pain 727
vomiting 695
nausea and vomiting 606
cancer pain 461
headache 440
Postoperative pain 382
discomfort 356
discomfort 345
hypothermia 296
sleepiness 241
Sedation 226
constipation 225
seizures 205
cough 197
agitation 166
back pain 157
abdominal pain 149
weakness 148
dizziness 142
breakthrough pain 120
low back pain 103
diarrhea 88
paresthesia 88
fatigue 86
dental pain 83
numbness 78
ataxia 75
hypercapnia 71
distraction 68
functional recovery 61
respiratory distress 57
Neuropathic pain 56
dyspnea 56
chest pain 52
bone pain 50
arthralgia 45
acute stress 44
tremor 44
erythema 43
paresis 43
Wind 40
spasm 40
collapse 39
renal colic 38
spasticity 37
colic 35
angina 34
Postoperative nausea and vomiting 34
neuralgia 32
pelvic pain 32
myalgia 30
shoulder pain 28
insomnia 28
anorexia 26
facial pain 26
sore throat 25
tachypnea 24
muscle rigidity 23
orofacial pain 22
neck pain 21
chronic back pain 20
hypalgesia 20
epigastric pain 19
knee pain 19
leg pain 19
bradypnea 18
Grimace 16
limb pain 16
pallor 16
postpartum pain 16
cyanosis 15
exhaustion 15
myoclonus 14
Severe pain 14
ENT 14
hyperesthesia 14
lethargy 14
sciatica 14
flushing 13
vertigo 13
hypotonia 13
tingling 13
retching 13
incoordination 13
catatonia 13
paraparesis 12
acute abdominal pain 12
dysesthesia 12
chills 11
acute abdomen 11
bloating 11
arm pain 11
hip pain 11
snoring 11
apathy 11
despair 11
Visceral pain 10
starvation 10
dysuria 10
flank pain 9
PAIN 9
Labor pain 9
syncope 9
acidity 9
hypocapnia 8
oliguria 8
lightheadedness 8
twitching 8
Ill 8
impaired motor coordination 8
stridor 8
hyperoxia 8
blurred vision 7
Inflammatory pain 7
hunger 7
dystonia 7
otalgia 7
Postoperative nausea 7
shortness of breath 7
regurgitation 7
hand pain 7
abdominal discomfort 6
No pain 6
blepharospasm 6
tinnitus 6
acute low back pain 6
Pain at rest 6
overweight 6
clonus 5
skin irritation 5
hoarseness 5
right upper quadrant pain 5
skin pain 5
photophobia 5
bladder pain 5
stump pain 5
hypertonia 5
tonic-clonic seizure 4
groin pain 4
testicular pain 4
joint stiffness 4
abnormal gait 4
Central pain 4
Hudson 4
Welt 4
generalized pain 4
memory loss 4
renal pain 3
decreased appetite 3
chronic constipation 3
Intractable pain 3
thinning 3
stomach pain 3
polyuria 3
heel pain 3
Post dural puncture headache 3
more...
Drug
Fentanyl 277
Bupivacaine 193
Clonidine 126
Cardiovasc 90
Propofol 89
CSF 81
Monit 71
Ketorolac 66
caffeine 63
Dermatol 43
9-THC 40
Butorphanol 38
Codeine 37
MAP 37
Medetomidine 35
ICI 35
nitroglycerin 34
Codeine 33
lysine 32
Xylocaine 31
DHT 30
DHT 30
Nephron 27
Gabapentin 26
Tapentadol 26
Atropine 25
ENT 20
Ringer's solution 17
Marcaine 17
Indomethacin 16
Histamine 16
Tramal 16
Ethanol 15
Ziconotide 15
Morphine sulfate 15
Xylocaine 14
Pregabalin 14
Diclofenac sodium 13
EE2 13
Demerol 13
Ketorolac tromethamine 12
MgSO4 11
Meconium 11
Xylocaine 11
Voltaren 11
L-tyrosine 11
PCP 10
Tramadol hydrochloride 10
CPM 10
Subutex 9
Phentolamine 9
Proglumide 9
Leaf 9
Scopolamine 9
Nubain 9
FLP 9
Parecoxib 8
Fentanyl citrate 8
CTX 8
Alvimopan 8
CaCl2 8
CaCl2 8
Misoprostol 8
CaCl2 8
Portal 8
Thiopentone 8
Demerol 8
Naropin 8
THA 7
Dipyrone 7
DMI 7
Gel 7
Atipamezole 7
Nimesulide 7
Lornoxicam 7
Domperidone 7
Morphine hydrochloride 7
lactose 7
mepivacaine hydrochloride 7
IL-1ra 7
IL-2 7
CDP 7
Triad 6
Emla 6
Kenyan 6
Asn 6
Angiotensin II 6
TAT 6
Emla 6
CAM 6
ABC 6
Narcan 6
Reserpine 6
Captopril 6
Valdecoxib 6
EPI 6
Emla 6
Dormicum 6
Flunitrazepam 6
Dilaudid 6
Anexate 5
DEX 5
Tenoxicam 5
Duloxetine 5
Syntocinon 5
Diphenhydramine 5
Hyaluronidase 5
Magnesium sulfate 5
Profenid 5
Nubain 5
Menthol 5
Innovar 5
Rimonabant 5
BoNT/A 5
Hyaluronidase 5
Etodolac 5
Dextropropoxyphene 5
CTX 4
Dexon 4
Sulpiride 4
Ultiva 4
Feldene 4
Oxycon 4
Glucagon 4
Methylprednisolone 4
Remifentanyl 4
Naproxen sodium 4
KGF 4
CTX 4
ascorbate 4
Cimetidine 4
Apomorphine 4
p75 4
Flunixin meglumine 4
Butorphanol tartrate 4
Ginger 4
Ritanserin 4
TMS 4
Opium 4
Bestatin 4
ROS 4
Cimetidine 4
Check 3
Posture 3
Ginseng 3
Hypnomidate 3
Lumiracoxib 3
Nesacaine 3
Capsicum 3
Versed 3
Adenosine triphosphate 3
DDAVP 3
Ketalar 3
Asthma 3
Flurbiprofen axetil 3
Frontal 3
C2H5Cl 3
Dextrose 3
Methylene blue 3
Sodium nitroprusside 3
more...
Enzyme
mitogen-activated protein kinase 75
protein kinase C 66
protein kinase 53
ERK 53
acetylcholinesterase 43
peroxidase 40
ACS 34
P-glycoprotein 31
adenylate cyclase 30
MAP 30
cholinesterase 26
hyaluronidase 24
CD10 24
hyaluronidase 24
creatine kinase 24
guanylate cyclase 24
renin 22
alanine aminotransferase 21
NO synthase 19
BIS 18
monoamine oxidase 17
tyrosine hydroxylase 17
phosphodiesterase 17
monoacylglycerol lipase 17
phospholipase C 15
aspartate aminotransferase 15
ACE 14
lipase 13
CD13 12
tryptophan hydroxylase 12
prostaglandin synthetase 11
CYP3A4 11
PCP 10
thromboplastin 10
alkaline phosphatase 10
CPM 10
lipoxygenase 10
ADH 9
MEK 9
trypsin 9
alcohol dehydrogenase 9
phospholipase A2 9
caspase-3 8
thrombin 8
dopamine beta-hydroxylase 8
luciferase 8
PRE 7
lipoprotein lipase 7
NADPH-diaphorase 7
GRK5 6
CPT 6
focal adhesion kinase 6
CPT 6
superoxide dismutase 6
tissue plasminogen activator 6
soluble epoxide hydrolase 6
botulinum neurotoxin 6
BMT 6
CPT 6
TAT 6
lactate dehydrogenase 6
demethylase 5
phosphatidylinositol 3-kinase 5
APC 5
ATPase 5
AST 5
SCS 5
catalase 5
NOS 5
collagenase 5
arginine decarboxylase 4
MIP 4
arginine decarboxylase 4
carboxypeptidase A 4
glutamate decarboxylase 4
calcineurin 4
plasmin 4
gamma-glutamyl transpeptidase 4
dipeptidyl peptidase IV 4
choline acetyltransferase 4
CPR 4
CaMKII 4
AMPK 4
GRK2 3
caspase-1 3
reverse transcriptase 3
proteasome 3
Lys4 3
apyrase 3
meprin 3
deaminase 3
asparaginase 3
MTD 3
prostate-specific membrane antigen 3
tryptase 3
CPN 3
FAST 3
NADPH oxidase 3
PPH 3
diaphorase 3
prostate-specific antigen 3
NADPH oxidase 3
complex I 3
PDE 3
cGMP phosphodiesterase 3
DAT 3
GTP cyclohydrolase I 3
adenosine deaminase 3
adenosine deaminase 3
UDP-glucuronosyltransferase 3
cathepsin L 2
endothelin-converting enzyme 2
alpha-amylase 2
cathepsin S 2
glutamate dehydrogenase 2
3alpha-hydroxysteroid dehydrogenase 2
IOR 2
transcriptase 2
glutathione S-transferase 2
RNA polymerase 2
aspirin esterase 2
matrix metalloproteinase 9 2
MCS 2
thermolysin 2
caspase-9 2
adenosine kinase 2
diaphorase 2
5'-nucleotidase 2
carbonic anhydrase 2
heme oxygenase 2
carboxypeptidase E 2
GABA transaminase 2
12-lipoxygenase 2
urokinase-type plasminogen activator 2
NQO1 2
beta-lactamase 2
SpeB 2
pepsin 2
5alpha-reductase 2
beta-glucuronidase 2
CPS 2
lysozyme 2
glutaminase 2
kallikrein 2
5alpha-reductase 2
glutaryl-CoA dehydrogenase 2
methionine synthase 2
IKK 2
elastase 2
SRR 2
beta-galactosidase 2
glutamate dehydrogenase 2
PARP 2
methionine synthase 2
glutamate dehydrogenase 2
PKG 1
homogentisate 1,2-dioxygenase 1
chymopapain 1
aldolase 1
PMT 1
more...
Compound
Dec 1930
Clin 1786
oxygen 897
Morphine 799
water 660
ASA 485
sodium 378
Naloxone 333
glucose 330
calcium 300
CO2 274
sulfate 260
acetic acid 250
5-HT 243
Gly 243
tyrosine 242
Phe 235
Ketamine 231
GABA 230
GABA 230
N2O 217
glutamate 211
noradrenaline 191
Bupivacaine 188
arginine 173
APAP 170
potassium 146
leucine 145
ethanol 143
NMDA 140
DAMGO 137
HCl 131
Dexmedetomidine 130
Buprenorphine 128
Tramadol 127
methionine 125
NH2 120
Lidocaine 119
nitric oxide 109
Remifentanil 107
T10 96
D-Ala 95
Meperidine 91
Propofol 89
galactose 88
ACTH 87
cAMP 80
Ropivacaine 79
Naltrexone 76
His 73
lysine 72
gamma-aminobutyric acid 70
threonine 70
phosphate 66
caffeine 64
nitrogen 64
alanine 63
Midazolam 63
Ketorolac 63
Adrenal 57
creatinine 57
ATP 55
Optimal 53
Sufentanil 52
DNA 52
salt 50
DBA 50
acetate 49
TNF 49
DBA 48
DBA 48
Diazepam 47
tryptophan 45
PAG 45
formaldehyde 45
Capsaicin 44
Methadone 44
sodium chloride 43
Alfentanil 42
Oxycodone 42
Nalbuphine 41
5-hydroxytryptophan 41
PGE2 39
AMP 38
Ibuprofen 37
T11 36
Cardiol 36
tryptophan 36
tryptophan 35
Substance P 35
tryptophan 35
urea 35
ICI 35
Parenteral 35
Codeine 34
ACS 34
ACS 34
DMSO 33
Diclofenac 33
Oxytocin 33
Butorphanol 33
cGMP 32
phenol 32
bromide 32
MAP 32
Pentazocine 31
Pentazocine 30
DHT 30
NOP 30
Droperidol 30
piperidine 29
piperidine 29
aspartic acid 29
AEA 29
Cortisol 28
Neurotensin 28
hydrogen 28
Ketoprofen 28
glycerol 28
PGE 27
Norepinephrine 26
Asp 26
MOP 25
Dynorphin 25
Atropine 25
AMPA 24
Yohimbine 24
Halothane 24
nicotinamide 24
Dexamethasone 24
serine 23
chloroform 23
COX 23
6-12 22
salicylic acid 22
Salt 22
iron 22
hydroxyindoleacetic acid 21
Baclofen 21
PEG 21
Adenosine 21
ACh 21
Dopamine 20
A 1 19
Sucrose 19
Melatonin 19
acetone 19
Isoflurane 18
methanol 18
prostaglandin E1 18
Neostigmine 17
Indomethacin 16
Sevoflurane 16
Histamine 16
Agmatine 16
Glutamate 16
ADP 16
A 3 16
AEA 16
Calcitonin 16
more...