Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Ovarian follicular fluid (FF) of a number of species contain regulatory peptides secreted by granulosa cells or by autonomic nerve terminals. In this report we demonstrate the presence of authentic (HPLC-verification) angiotensin II and III as well as of substance P (SP) in human FF obtained from hMG stimulated infertile patients undergoing in vitro fertilization. Angiotensin II/III (AII/III), estradiol (E2) and progesterone concentrations increase with the size of the follicles. SP concentrations did not vary significantly in FF of various sizes. These peptide concentrations in FF are about 10-fold higher than those measured in the serum of the same patients. Attempts to correlate SP, AII/III, E2 and progesterone concentrations in the individual FF with the ability of an oocyte to be fertilized, failed. Neither AII/III, SP, E2 nor progesterone concentrations were different in these subclasses of FF. Follicles of patients punctured under general anesthesia contained significantly more SP than follicles of patients which had lumbar analgesia. AII/III concentrations were the same in FF of both treatment groups. The presence of angiotensin II and III in FF in increasing concentrations depending on the maturity of the follicle and the inability of general anesthesia to affect the AII/III concentrations suggests that this peptide is produced within the ovary.
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PMID:Angiotensin II/III and substance P in human follicular fluid obtained during IVF: relation of the peptide content with follicular size. 245 91

The stainless steel cannulas were implanted to male rabbits of 2.0-2.6 kg, under Na-pentobarbital anaesthesia with the aid of a stereotaxic instrument. Co-ordinates of the locations of the implantations were P 9.5, LR 1.0, H 10.0 mm (under outer surface of the skull) on both sides of periaqueductal gray (PAG). After 1 wk, nociception was assessed by measuring the latency of the escape response (ERL) elicited by strong radiant heat focused on the nose of rabbits. The analgesic effect of morphine (4 mg/kg, iv) was blocked by injecting angiotensin II (AII, 0.1 microgram) into PAG (P less than 0.01, ANOVA), but not by injecting the same dose of AII into the vicinity of PAG (P greater than 0.05, ANOVA). Morphine tolerance was induced by iv infusion of morphine for 2 d, the dose being 50 mg/(kg.8 h) on d 1 and 75 mg/(kg.8 h) on d 2. On d 3, the degree of tolerance was checked by the analgesia induced by iv morphine 4 mg/kg. Tolerance was partly reversed by injecting AII anti-serum 2 microliters into PAG(P less than 0.01, ANOVA). The results suggest that AII in PAG is antagonistic to morphine analgesia and is involved in the development of morphine tolerance.
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PMID:[Antagonism to morphine analgesia and involvement in morphine tolerance of angiotensin II in periaqueductal gray of the rabbits]. 262 10