Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0344307 (
analgesia
)
28,200
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The anti-morphine peptide PPC from dog brain has an inhibitory effect on morphine
analgesia
. It is highly homologous to
DBI
. The analgesic effect of bovine
DBI
was measured, showing the potentiation effect on morphine
analgesia
. In order to study the relationship between PPC and
DBI
, cDNA library derived from dog liver had been screened using partial gene of rat
DBI
as a probe. A positive clone was obtained. The entire sequence of the insert of this positive clone provided complete sequence of a peptide which was identified as the
DBI
peptide. It shows 88.5% homology with pig
DBI
, 87.4% with bovine, 83.9% with human, 46.5% with yeast, respectively. The sequence of N-terminal 50 amino acid residues except 55th, 58th site and C-terminal 17 amino acids is the same to
DBI
from dog. PPC has 23 amino acids more than
DBI
inside.
...
PMID:Cloning and Sequencing of cDNA Encoding the Diazepam Binding Inhibitor (DBI). 1216 1
