Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We investigated the influence of apomorphine, amphetamine, amantadine, dimethylaminoadamantane, nomifensine, ergometrine and beta-phenylethylamine on cataleptogenic and antinociceptive action of analgesics in rats. Nomifensine, apomorphine, beta-phenylethylamine, amantadine and ergometrine antagonized the catalepsy induced by morphine and codeine. Catalepsy induced by fentanyl was depressed only by nomifensine and apomorphine. Amphetamine only slightly antagonized the analgesic-induced catalepsy and the effects were not dose-dependent. Dimethylaminoadamantane did not antagonize catalepsy at all. Antinociceptive action of morphine and codeine was antagonized by apomorphine and amphetamine. Ergometrine counteracted the action of morphine, and beta-phenylethylamine decreased the action of pentazocine. The results suggest that: 1. There are differences in the mechanism of cataleptogenic action of the opiates (morphine and codeine) and fentanyl; 2. Catalepsy after analgesia differs from the catalepsy produced by neuroleptics in respect of interaction with such drugs as amphetamine, apomorphine or dimethylaminoadamantane. Analgesic-induced catalepsy seems to depend on the presynaptic inhibition of dopaminergic neurotransmission; 3. Stimulation of the central dopaminergic system in rat brain either does not change or weakly antagonizes the action of analgesics in the hot plate test.
Pol J Pharmacol Pharm 1981 Oct
PMID:Central action of narcotic analgesics. VIII. The effect of dopaminergic stimulants on the action of analgesics in rats. 611 81

The review, based largely on our own results describes the present state of knowledge of some aspects of opioid peptides and their physiological role. Studies on the effect of opioid peptides and opiates on brain function and the changes of brain level of endogenous opioids under various conditions have demonstrated, among others, the role of opioids in stress and stress-induced analgesia, the involvement of various opioid receptors in spinal mechanisms of analgesia, the inhibitory role of dynorphin in seizures in contrast to proconvulsant action of beta-endorphin system and mu receptor, and led to postulation of the role of beta-endorphin interaction with serotonin for ingestive behavior and a possible involvement of beta-endorphin system in the mechanism of action of antidepressant treatments.
Pol J Pharmacol Pharm
PMID:Some aspects of physiology and pharmacology of endogenous opioid peptides. 614 28

The participation of the endogenous opiate-like peptide system in the mechanism of the analgesic effect of the stimulation of the peripheral nervous system has been generally accepted but the published results of the investigations on this topic are controversial. The authors studied the plasma beta-endorphin-like activity in 10 healthy subjects before and after pinpoint receptor stimulation (prs). This immunoreactive activity showed fairly high differences in successive determinations but was not significantly different before and after prs. The authors believe that this is an argument against the hypothesis assuming release of pituitary endorphins into the circulating blood after acupuncture but cannot rule out the role of the cerebral beta-endorphin system in the mechanism of acupuncture analgesia.
Neurol Neurochir Pol
PMID:[Plasma concentration of immunoreactive beta-endorphin in healthy persons during pinpoint stimulation of receptors (acupuncture)]. 632 35

Male Wistar rats were irradiated with a single 600 R dose of X rays and then treated for 3 or 6 days with intraperitoneal injections of steroid hormones. In both irradiated and non-irradiated rats the morphine analgesia was potentiated after 3, and even more after 6 days of pretreatment with testosterone and hydrocortisone, while the effect of morphine was weaker after pretreatment with estradiol and desoxycortone. The results correlate with an increase or decrease of the morphine level in the brain. The results cannot be explained by changes in the activity of beta-glucuronidase.
Pol J Pharmacol Pharm
PMID:Interaction of morphine and steroid hormones in the postirradiation disease in rats. 646 59

Tail-flick latencies and morphine concentrations in the blood serum, brain (without striatum) and spinal cord were measured in rats receiving 10 mg/kg ip morphine with or without haloperidol pretreatment (0.1 or 1 mg/kg sc). Haloperidol pretreatment dose-dependently potentiated the analgesic action of morphine and interfered with tissue morphine levels. Morphine levels in the spinal cord were similar to those in the blood serum and were dose-dependently increased by haloperidol pretreatment; in the brain the appearance of morphine was delayed, the levels lower than in the blood serum, and the effect of both doses of haloperidol (augmentation of morphine level) was similar. The results indicate that the analgesic effect of morphine in the tail-flick test is correlated better with the spinal than cerebral morphine levels and that potentiation of morphine analgesia by haloperidol is due, at least in part, to pharmacokinetic interaction.
Pol J Pharmacol Pharm
PMID:Behavioral and pharmacokinetic interaction between morphine and haloperidol in the rat. 646 60

The aim of this paper was to study the interaction between neurotensin and both enkephalins or its synthetic analogue D-Ala2-metenkephalinamide, or tuftsin, on the antinonciceptive effect of these peptides in mice after intracisternal injection. Antinociception was measured by the hot-plate method. It was shown that neurotensin antagonized evidently the antinociceptive effect of enkephalins and their analogue. On the contrary, neurotensin and tuftsin were agonists in induction of analgesia. It is concluded that neurotensin modulates in an opposite way the function of the enkephalinergic neurons and the central action of tuftsin.
Acta Physiol Pol
PMID:Interaction on the antinociceptive effect between neurotensin and enkephalins or tuftsin. 654 85

In C57BL/6 mice caffeine antagonized morphine-induced hyperactivity. This effect was most evident when caffeine was used in doses that slightly increased locomotor activity. Given at the same dose caffeine did not affect morphine-induced analgesia. Two possibilities of explanation of this effect are discussed: action of caffeine on dopaminergic mechanisms responsible for morphine-induced running fit through its effect on cyclic AMP level, and a direct action of caffeine on delta opiate receptors involved in the stimulatory effect of morphine.
Pol J Pharmacol Pharm
PMID:Caffeine interferes with morphine-induced hyperactivity but not analgesia. 667 94

The effects of single or repeated electroconvulsive shock (ECS) (once daily for 7 days) on rat behavior and on the level, utilization and uptake of biogenic amines in rat brain were studied between one and ten days after the last ECS. It has been found that a single ECS caused catalepsy and analgesia, depressed locomotor activity and locomotor hypermotility produced by amphetamine and nomifensine (but not by apomorphine) and decreased the frequency of head twitch response evoked by LiCl. Repeated ECS also induced catalepsy and analgesia but enhanced both the spontaneous locomotor activity and amphetamine, nomifensine and apomorphine-induced hypermotility, and increased the frequency of head twitch response produced by LiCl, 5-HTP and 5-methoksytryptamine. Single and repeated ECS did not change exploratory motility or stereotyped behavior induced by apomorphine, but enhanced haloperidol-induced catalepsy and altered dopamine and serotonin levels in the rat brain. The utilization of NA and DA was not changed by repeated ECS, whereas the uptake of these amines was slightly reduced. The present results provide evidence that a single ECS depresses but repeated ECS augments some behavioral responses to dopaminergic and serotonergic agonists. The possible biochemical mechanisms involved in these effects of ECS are discussed.
Pol J Pharmacol Pharm 1983
PMID:Effects of electroconvulsive shock on monoaminergic systems in the rat brain. Thesis. 668 70

1. CAM--a new type of opiate antagonist [10, 11] was used to study the types of opiate receptors (OR) involved in the analgesic and narcosis potentiating effects of different opiates. The analgesic assays were: hot plate, algolytic test (rat) and acetic acid stretching test (mouse). 2. The in vivo equivalent of pA2 value (apparent pA2) for naloxone (NX) and CAM was determined with each opiate agonists. 3. The estimated pA2 values for analgesia did not differ significantly from those obtained for anesthesia in the case of NX, however, if CAM was used as antagonist the pA2 values were the same as with NX in the algolytic test, but different result was obtained when analgesia was measured by hot plate and stretching test, and narcosis potentiation was examined. 4. It was concluded that NX and CAM interact with the same OR when algolytic test was used, however different type of OR might be involved in hot plate and stretching assays and anesthesia potentiation, too.
Pol J Pharmacol Pharm 1982
PMID:Quantitative studies of the antagonism by naloxone and N-cyclopropylmethyl-norazido-dihydroisomorphine (CAM) of different opiates. 689 45

Percutaneous electrostimulation is a new method of analgesia and it is hoped that good effects can be obtained in painful syndromes resistant to other therapeutic methods. Its basic advantage is the possibility of controlling the parameters during the stimulation by the patient who is wearing a miniaturized apparatus generating impulses of desired parameters. The authors tried out the effectiveness of ministimulators of Polish design for the treatment of neuralgic pains in inpatients and outpatients. The electrodes were placed at the sites of greatest pain and along peripheral nerves. The immediate analgesic effect of the stimulation, its degree and duration were evaluated. In 67% of patients an immediate improvement was obtained, and in 16% of them the pain disappeared completely. The authors stress that the effectiveness of this method equals that of various types of acupuncture and discuss a possible common mechanism of action of both methods.
Neurol Neurochir Pol
PMID:[Evaluation of the direct analgesic effect of ministimulators]. 696 42


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>