Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 105 normal spontaneous deliveries the effect of inhalation analgesia with Methoxyfluran (Penthrane) was studied. Penthrane was administered intermittently with the Penthrane oxilator (Rod inhalator of Abbott). The initial concentration was 0.25 volume%. The maximal concentration was 0.35 volume% of Penthrane. Fetal monitoring records were obtained in all deliveries. In 49 cases (46.7%) intra- and post-partum microblood studies were obtained. In 85 women (81.0%) the result of the analgesia was good. Nausea occurred in 21 women (20%). There were no abnormal fetal monitoring patterns. The Apgar scores of the newborns were between 8 and 10. The actual pH's were between 7.24 and 7.41. The third stage of labour was normal in all cases.
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PMID:[Inhalation analgesia with methoxyfluran (penthrane) in obstetrics (author's transl)]. 0 53

The anaesthetic management of patients requiring surgical correction of idiopathic scoliosis using the Harrington Rod Instrumentation Technique is discussed. Special emphasis is made of the need to minimise blood loss, to limit homologous blood transfusions and to provide adequate postoperative analgesia.
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PMID:Practical anaesthesia: the anaesthetic management of major spinal surgery in children. 50 53

In the plastics industry, various chemical additives are used to improve certain properties of plastics. Some of these chemicals, that might be toxic, have been proved to leach from the plastic containers and mix with their contents such as food oils, beverages, drugs, etc. Locally manufactured polyvinyl chloride (PVC) jerrycans were bought from the market and cut into small chips of 0.5 cm in the larger dimension. Four grams of chips were extracted with 20 ml cottonseed oil in the autoclave for 1 h at 121 degrees C. The extract was prepared daily and given orally to adult MFI mice in a dose of 10 ml kg(-1) body weight. Pure cottonseed oil was prepared under the same conditions and given in a dose of 10 ml kg(-1) body weight to the control group. Treatment of both groups continued for 1 month. Each group comprised 60 animals, regardless of sex. Effects of the oil plastic extract were observed on blood elements, serum transaminases (aspartate aminotransferase, AST, and alanine aminotransferase, ALT), organ-to-body weight of the liver, kidneys and brain, and the nervous system (effects on the neuromuscular junction and analgesia, using the Rota-Rod(R) treadmill 'RRT', and the hot plate, respectively). All the results were subjected to Student's t-test. The results showed that the extract induced significant effects: an increase in the activities of AST (p< 0.001) and ALT (p< 0.02), an increase in the mean corpuscular haemoglobin concentration (MCHC) (p< 0.01), and the monocyte count (p< 0.01). It decreased the white blood cell count (WBC) (p< 0.01), the mean corpuscular volume (MCV) (p< 0.05), and the lymphocyte count (p< 0.05). It also reduced the weight of the liver (P< 0.01), kidneys (P< 0.05), and the endurance time on the RRT (p< 0.001).
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PMID:Effects of oil plastic extract on mice. 1126 Jul 89

Paeoniflorin (PF), one of the active chemical compounds identified from the root of Paeonia lactiflora Pall, has been well-established to exhibit various neuroprotective actions in the central nervous system (CNS) after long-term daily administration. In the present study, by using the bee venom (BV) model of nociception and hypersensitivity, antinociceptive effects of PF were evaluated by intraperitoneal administration in conscious rats. When compared with saline control, systemic pre- and post-treatment with PF resulted in an apparent antinociception against both persistent spontaneous nociception and primary heat hypersensitivity, while for the primary mechanical hypersensitivity only pre-treatment was effective. Moreover, pre- and early post-treatment with PF (5 min after BV injection) could successfully suppress the occurrence and maintenance of the mirror-image heat hypersensitivity, whereas late post-treatment (3 h after BV) did not exert any significant impact. In the Rota-Rod treadmill test, PF administration did not affect the motor coordinating performance of rats. Furthermore, systemic PF application produced no significant influence upon BV-induced paw edema and swelling. Finally, the PF-produced antinociception was likely to be mediated by endogenous opioid receptors because of its naloxone-reversibility. Taken together, these results provide a new line of evidence showing that PF, besides its well-established neuroprotective actions in the CNS, is also able to produce analgesia against various 'phenotypes' of nociception and hypersensitivity via opioid receptor mediation.
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PMID:Antinociceptive effects of systemic paeoniflorin on bee venom-induced various 'phenotypes' of nociception and hypersensitivity. 1785 74