Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Polypeptides are endogenous agents, involved in the regulation of many physiologic functions and the pathogenesis of several diseases. Polypeptide antagonists form a group of new chemical entities which may provide valid therapeutic agents. Some polypeptides (angiotensin, kinins) are released through the action of proteolytic enzymes (renin, kallikreins) and act as hormones or autacoids; others (substance P, neurotensin) are synthetized by nervous cells to serve as neurotransmitters or neuromodulators. The main homeostatic role of the renin-angiotensin system is to uphold high systemic arterial blood pressure. Overproduction of renin and insufficient checking of renin secretion are among the most common causes of arterial hypertension. Several forms of arterial hypertension (neurovascular, idiopathic) benefit from a reduction in renin-angiotensin system activity. This is achieved either through decreasing renin secretion, by inhibiting conversion of angiotensin I into angiotensin II, or through blocking the peripheral actions (at the receptor sites) of angiotensin II. Renin secretion is very significantly reduced by beta-blocking agents (propranolol); conversion of angiotensin I into angiotensin II is inhibited by teprotide, captopril and their derivatives; peripheral actions of angiotensin II are blocked by saralasin. Bradykinin and related agents produce vasodilation, increase vascular permeability and stimulate pain fibers. Kinins thus reproduce the cardinal features of inflammation and are held to be mediators of the inflammatory reaction. The substance P neuropeptide is found in the brain and bowel; it may act as a transmitter of the sensation of pain at the spinal cord and central nervous system sites. Among other effects outside of the brain, substance P is a potent vasodilator and inhibits renin secretion. Neurotensin is a neuropeptide which produces hypothermia, muscular relaxation and analgesia. Outside of the brain, this peptide is involved in the regulation of gastric secretion, intestinal motility and insulin and glucagon secretion. The vasoactive intestinal peptide, found in certain cholinergic nerve endings, is a large peptide which inhibits gastric secretion, intestinal motility and vascular tone.
Sem Hop 1984 Mar 29
PMID:[Polypeptides and antagonists]. 620 6

During 2588 coronarography examinations conducted over a period of 4 years, assisted circulation was employed in 63 cases to reduce the risks of the examination procedure in particularly debilitated patients. These high risk cases included 48 patients with unstable angina resistant to medical treatment and 45 cases of recent infarcts with complications. Mortality with assisted circulation was very low, in spite of the severe nature of the affections, but the authors use this technique in only a limited number of cases, mainly because of the risk of lower limb ischemia, and the possibility of using intravenous nitroglycerin and analgesia from neuroleptics for examination. For this reason the number of cases examined in this way has dropped from 4% in 1977 to 2% in 1978, though assisted circulation is still employed in certain particularly severe cases of angina, and for infarcts with complications.
Sem Hop 1980 Oct 15
PMID:[Assisted circulation during coronarography: advantages and limitations. A report on 63 cases (author's transl)]. 625 75

Tiapride, a substituted benzamide, exerts an antalgic effect in man. To examine the possibility that tiapride analgesia might be related to a mechanism involving a release of endogenous opioids, the acute effects of an intravenous injection of the drug on plasma radioimmunoassayable beta-endorphin were studied in patients with pain from cancer (placebo-tiapride double-blind randomized trial). Seeing that substituted benzamides affect prolactin secretion, the plasmatic levels of prolactin and dopamine, a known factor inhibiting prolactin release, were studied as well. The tiapride infusion produced a slight but significant increase in plasma beta-endorphin level, an early and significant increase in plasma prolactin, and a sudden and highly significant decrease in plasma dopamine. These results are compatible with the hypothesis that tiapride influences the neuroendocrine system.
Sem Hop
PMID:[Effects of tiapride infusion on plasma levels of beta-endorphin, prolactin and dopamine in patients with pain from cancer (author's transl)]. 626 92

Missing limb pain remains a preoccupying and worrisome problem for amputees. Approximately one-third of amputees experience missing limb pain. Although it often abates with time, this pain disables the patient in the first few months following amputation. We carried out a therapeutic trial of oral tablets of tiapride, which was given to twenty patients in three daily doses of 50 to 100 mg each. Tiapride was the sole medication in most instances. Analgesia appeared after an interval of 24 hours to 15 days. Clinical tolerance was excellent. Efficiency in terms of resolution of pain is observed in most cases.
Sem Hop 1982 Oct 21
PMID:[Tiapride and pain in amputees]. 629 62