Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0344307 (
analgesia
)
28,200
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide,
CER
) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8,
CER
and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and water; antinociception; sedation; catalepsy; ptosis, antistereotypic, anticonvulsive and tremorolytic effects; inhibition of self-stimulation. Effects of
CER
in man comprise sedation, satiety, changes in mood,
analgesia
and antipsychotic effects. A modulation of central dopaminergic functions appears to be one possible mechanism of
CER
and its analogues. A common denominator for all effects of
CER
is, at present, not evident.
...
PMID:Caerulein and its analogues: neuropharmacological properties. 391 10
