Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In Aberdeen, Scotland, researchers compared the efficacy rate of medical abortion with that of vacuum aspiration and examined their complications and the nature and incidence of short-term sequelae. All 363 pregnant women had amenorrhea for less than 63 days. The medical abortion procedure consisted of administration of 600 mg mifepristone followed by 1 mg gemeprost (vaginal pessary) 48 hours later. Women who underwent medical abortion at less than 50 days gestation were less likely to experience pain than those who underwent medical abortion between 50 and 63 days gestation (mean pain related index [PRI] scores, 20.5 vs. 25.5, p = 0.04 and analgesia during inpatient treatment, 43% vs. 63%; p = 0.02). Medical abortion was less effective at 50-63 days gestation than at less than 50 days gestation (complete abortion, 98% vs. 92.6%). 90% of women requiring curettage after medical abortion were at 50-63 days gestation. Gestation affected neither pain nor efficacy rates of vacuum aspiration, however. At follow-up 16 days after the procedure, the significant differences in the medical sequelae of the 2 procedures during and immediately after abortion disappeared. The short-lived sequelae did not greatly affect recovery times. For example, even though women who underwent vacuum aspiration required more time off work than those who underwent medical abortion (2.5 vs. 1.2 days; p = 0.007), the return of normal daily activities was essentially the same for both groups (0.6-1.3 vs. 0.8-1.5 days). These results suggest that at gestations of less than 50 days, the 2 procedures are equally effective and have similar 0-21 day complication rates. On the other hand, at 50-63 days gestation, medical abortion becomes more unpleasant and its efficacy begins to diminish. In conclusion, at higher gestations, women who do not prefer one method over another will probably find vacuum aspiration more acceptable than medical abortion.
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PMID:A comparison of medical abortion (using mifepristone and gemeprost) with surgical vacuum aspiration: efficacy and early medical sequelae. 786 93

Music therapy has been used in multiple health care settings to reduce patient pain, anxiety, and stress. However, few available studies have investigated its effect on pain among breast cancer patients after radical mastectomy. The aim of this study was to explore the effects of music therapy on pain reduction in patients with breast cancer after radical mastectomy. This randomized controlled trial was conducted at the Surgical Department of Oncology Center, First Affiliated Hospital of Xi'an Jiaotong University from March to November 2009. A total of 120 breast cancer patients who received Personal Controlled Analgesia (PCA) following surgery (mastectomy) were randomly allocated to two groups, an intervention group and a control group (60 patients in each group). The intervention group accepted music therapy from the first day after radical mastectomy to the third admission to hospital for chemotherapy in addition to the routine nursing care, while the control group received only routine nursing care. Pain scores were measured at baseline and three post-tests using the General Questionnaire and Chinese version of Short-Form of McGill Pain Questionnaire. The primary endpoint was the change in the Pain Rating Index (PRI-total) score from baseline. Music therapy was found to reduce the PRI-total score in the intervention group significantly compared with the control group with a mean difference (95% CI) of -2.38 (-2.80, -1.95), -2.41 (-2.85, -1.96), and -1.87 (-2.33, -1.42) for the 1st, 2nd, and 3rd post-tests, respectively. Similar results were found for Visual Analogue Scale (VAS) and Present Pain Intensity (PPI) scores. The findings of the study provide some evidence that music therapy has both short- and long-term positive effects on alleviating pain in breast cancer patients following radical mastectomy.
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PMID:Effects of music therapy on pain among female breast cancer patients after radical mastectomy: results from a randomized controlled trial. 2153 35