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Query: UMLS:C0344307 (
analgesia
)
28,200
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The
corticotropin-releasing factor
(
CRF
) is involved in somatic pain regulation and may produce an analgesic effect in humans and animals, although the mechanisms of the
CRF
-induced
analgesia
remain unclear.
CRF
action is mediated by the
CRF
receptors of subtypes 1 and 2 (
CRF
-R1 and
CRF
-R2, respectively). Activation of the hypothalamic -pituitary -adrenocortical axis (HPA) is provided by
CRF
-R1; but
CRF
-R2 are also involved in the regulation of the HPA axis, and, respectively, glucocorticoids, the end hormones of the HPA axis, also participate in somatic pain regulation. Additionally, opioids may contribute to the
CRF
-induced
analgesia
. This article serves as an overview of the role of
CRF
-R1 and
CRF
-R2, as well as glucocorticoid and opioid receptors in peripheral
CRF
-induced
analgesia
in conscious rats, while we focused on the data obtained under normal (non-pathological) conditions including results of our studies in rats. The involvement of
CRF
-R1 and
CRF
-R2, glucocorticoids and opioid receptors was studied under the same experimental conditions following pretreatment with appropriate antagonists: NBI 27914, astressin
2
-B, naltrexone and RU 38486, respectively. Somatic pain sensitivity was measured by the tail flick latencies induced by thermal stimulus (tail flick test). Peripheral administration of the
CRF
caused both an increase in the tail flick latencies (analgesic effect) and plasma corticosterone levels. Pretreatment with NBI 27914, astressin
2
-B, naltrexone or RU 38486 attenuated the peripheral
CRF
-induced
analgesia
. The results obtained suggest that the peripheral
CRF
-induced analgesic effect may be mediated through the involvement of
CRF
-R1 and
CRF
-R2 as well as opioid and glucocorticoid receptors, including
CRF
-R2 and opioid receptors within periaqueductal gray matter of the midbrain.
...
PMID:The peripheral corticotropin-releasing factor (CRF)-induced analgesic effect on somatic pain sensitivity in conscious rats: involving CRF, opioid and glucocorticoid receptors. 2940 82
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