Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Osseous deposits secondary to advanced carcinoma of the prostate are a common feature of the disease. These deposits are most often seen in the lumbar spine and pelvis and cause severe and intractable pain, often requiring large quantities of strong analgesia for alleviation of pain. Relief of pain can be achieved by external irradiation of these deposits, but this relief may not be permanent and the disease may be so widespread that it is impracticable to treat all the deposits by irradiation. Deposits from carcinoma of the prostrate are usually multiple and all may cause pain at the same time. A method of delivering the radiation to all the deposits at the same time has been sought. Previous studies have shown that radioactive phosphorus (P32) can be used to obtain this localisation of radioactivity at sites of osseous activity. In this study 24 patients with bone metastases from carcinoma of the prostate were treated with radiophosphorus and methyl testosterone, or radiophosphorus with parathormone and calcium. An overall response rate of 58% shows this to be an effective palliative treatment. The results suggest there is a greater response when P32 is used in conjunction with parathormone and calcium, than with methyl testosterone.
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PMID:Carcinoma of the prostate: the treatment of bone metastases by radiophosphorus. 730 44

Analgesic effect of calcitonin administered in doses of 1, 3, and 5 U/100 g was studied in rats. Intrathecal administration of calcitonin (0.015 U) results in higher increase in analgesic effect compared to intraventricular injection. Intramuscular (1, 3, and 5 U/100 g) and intraventricular (0.1 U) injection of parathormone exert no analgesic effect, whereas intrathecal injection in a dose of 0.1 U resulted in statistically significant analgesia. High correlation was found for nociception and calcium level in blood. Nifedipine and isoptin (1, 5, and 10 mg/kg) were shown to reduce significantly the analgesic effect of calcitonin. On the membrane of the isolated neuron of mollusk calcitonin (10(-9) - 10(-7) M) increased and in a concentration of 10(-6) M decreased JCa. Inhibiting effect of isoptin on JCa was found for combined action of calcitonin and isoptin on the neuron membrane.
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PMID:[The effect of calcium-regulating hormones on pain sensitivity in rats]. 897 74

Minimally invasive parathyroidectomy is the procedure of choice for primary hyperparathyroidism due to parathyroid adenoma. Localization of the offending adenoma in minimally invasive parathyroidectomy (MIP) has been described in the literature aided by isotope, telescope or ultrasound guidance. We present a prospective study of two techniques based on surgeon experience. Thirty patients diagnosed with primary hyperparathyroidism at the Mater hospital in Dublin, Ireland were randomized to have a minimally invasive parathyroidectomy using surgical sonography (MIPUSS) or the conventional unilateral open procedure (OP) over a two year period. The age, sex and serum calcium/parathormone were comparable in both groups. There was no significant difference in complications between the two groups with temporary hypocalcemia occurring in 3 patients undergoing unilateral neck exploration and in 2 MIPUSS patients. There was one transient episode of recurrent laryngeal neuropraxia occurring in the OP group which resolved at 30 day follow-up. The incision size, operating time, hospital stay, and required post-operative analgesia were all markedly reduced in the MIPUSS group. In conclusion, MIPUSS is safe, effective and has advantages in terms of operating time, incision size and early discharge.
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PMID:Minimally invasive parathyroidectomy using surgical sonography. 2153 91