Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Four patients with venous occlusions were treated with a combined technique including thrombolysis and regional sympathetic blockade. The thrombolytic therapy was achieved with streptokinase and/or urokinase infusion via venous catheter located distal to the obliteration in flow direction. The dose of the thrombolytic agents ranged between 40,000 and 200,000 U/h and lasted for a period of 3 days to 6 weeks. Subsequent anticoagulation using systemic low dose heparin was conducted for a further 2 weeks. Initial sympathetic blockade with concomitant analgesia and vasodilatation was accomplished by bupivacain either at the stellate ganglion or epidurally depending on the thrombus location. The circulation and function of the affected extremities were restored after lysis and no amputation was necessary. The described procedure seems to offer promising possibility in the treatment of severe venous thromboses in high-risk patients.
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PMID:A combined technique of local thrombolysis and regional neural blockade in severe venous occlusions. 355 35

Chronic refractory angina pectoris is a clinical entity characterized by a persistent thoracic pain, despite pharmacological therapy (Canadian Cardiovascular Society functional class 3-4); the patients show a severe, diffuse coronary atherosclerosis not amenable to myocardial revascularization at coronary angioplasty or bypass grafting. This clinical entity which is becoming ever more frequent is a cause of a poor quality of life necessitating repeated hospitalization. Many therapeutic alternatives have been proposed for the treatment of these patients, but results were inconclusive. In this review their pathophysiological background, clinical efficacy, safety and complications are analyzed. Data concerning spinal cord stimulation, upper thoracic sympathectomy, high thoracic epidural analgesia, chronic-intermittent urokinase administration, enhanced external counterpulsation and transmyocardial laser revascularization are presented. Finally, the main research directions in this particular field are reported.
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PMID:[Non-pharmacological, non-conventional therapy of chronic refractory angina pectoris]. 1939 5