Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In comparison to the living conditions that existed before 1949, the People's Republic of China (PRC) represents a remarkable story of achievement. Western knowledge about the PRC has recently increased by leaps and bounds as detente with the United States has allowed many Americans to witness the "awakening of the dragon." Many of the achievements have been in the development of a health care delivery system that uniquely addresses the needs of the most populous country. There are numerous reports on the advancements made in manpower development and deployment, infectious disease control, family planning and acupuncture anesthesia and therapy. Yet there is little information about dental care in China. Dental disease being an essentially preventable disease has an interesting status in the Chinese health care system which relies on prevention rather than cure. In September and October 1974, the author visited five cities in China, Kwangchou (Canton), Peking, Tientsin, Suchou, and Shanghai and the respective countrysides except for Tientsin. Though any account or description is certain to be but a glimpse of Hsin Hua (the New China), the story is worth being told even if it must be accomplished by small chapters contributed by many individuals. In this light, the author explores the following areas: dental manpower training, which in China has produced stomatologists, dental technicians and dental nurses; the oral health status of school age children, dental care delivery and facilities, and probably the most remarkable while at the same time provocative areas, acupuncture analgesia and therapy.
 ...
PMID:Dental care in the People's Republic of China. 67 70

The anti-morphine peptide PPC from dog brain has an inhibitory effect on morphine analgesia. It is highly homologous to DBI. The analgesic effect of bovine DBI was measured, showing the potentiation effect on morphine analgesia. In order to study the relationship between PPC and DBI, cDNA library derived from dog liver had been screened using partial gene of rat DBI as a probe. A positive clone was obtained. The entire sequence of the insert of this positive clone provided complete sequence of a peptide which was identified as the DBI peptide. It shows 88.5% homology with pig DBI, 87.4% with bovine, 83.9% with human, 46.5% with yeast, respectively. The sequence of N-terminal 50 amino acid residues except 55th, 58th site and C-terminal 17 amino acids is the same to DBI from dog. PPC has 23 amino acids more than DBI inside.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 1998
PMID:Cloning and Sequencing of cDNA Encoding the Diazepam Binding Inhibitor (DBI). 1216 1

The aim was to compare the efficacy of transcutaneous electrical nerve stimulation (TENS) and local infiltration of 2% lidocaine in the relief of episiotomy pain measured using a pain visual analog scale (VAS). A randomized, double blind, controlled clinical trial was conducted from January 1 to May 15, 1998, in the Labor-Delivery Complex of Chong Hua Hospital, Cebu City. Skin electrodes were attached to two acupoints. "Shenmen" on the wrist and "hegu" on the hand are acupoints for general pain relief and relaxation. These acupoints were stimulated using a nerve stimulator. Stimulation was started during advance labor and discontinued right after episiorrhaphy. VAS scores were taken during certain periods and compared with VAS scores for those using the conventional method of 2% lidocaine infiltration into the episiotomy site. There were 68 patients who met the inclusion criteria. 38 in the TENS group and 30 in the Control group. The patients profile of the two groups did not differ significantly in terms of age, age of gestation, parity, and length of episiotomy. Among those with VAS score of 5 (bearable), 37% was failed TENS, requiring rescue anesthesia. The proportion of patients with pain during episiotomy and 12 hours after episiorrhaphy showed no significant difference between the two groups. But during episiorrhaphy and 1 hour after episiorrhaphy, the TENS group was superior to the lidocaine group, with p-values of 0.05 (0.0392 and 0.0063, respectively) based on the Mann Whitney U-Test. Ambulation time was shorter in the TENS group. Episiotomy tenderness was nil in the TENS group. There was no swelling and edema in the perineum of patients in the TENS. The need for oral analgesics was likewise much lower in the TENS group. TENS as a form of anesthesia-analgesia cannot totally alleviate episiotomy pain as measured by VAS scoring system, with 37% as failed TENS. The study showed there was a difference only in pain relief during repair, and 1 hour after repair. With TENS being superior to lidocaine, ambulation time was shorter and episiotomy tenderness was nil in the TENS group. Likewise, lesser number of patients requested for oral analgesics in the TENS group.
 ...
PMID:A randomized controlled trial of the efficacy of transcutaneous electrical nerve stimulation (TENS) versus lidocaine in the relief of episiotomy pain. 1217 68

The topic of eliminating the fear or pain of patients during dental therapy is gaining increasing attention from dentists across the country. The field of painless dental therapeutics involves a wide range of subjects, including stomatology, anesthesiology, and hospital management. We summarized the characteristics of sedation and analgesia technology in outpatient oral therapy, reviewed the common sedative and analgesic treatments, and discussed the disputes on the use of sedation and analgesia in dental procedures. We also reviewed the trends and breakthroughs in this area on the basis of our own clinica experiences.
Hua Xi Kou Qiang Yi Xue Za Zhi 2015 Dec
PMID:[The dispute and prospect of sedation and analgesia treatments in outpatient dental procedures]. 2705 44