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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A prospective double-blind study of the effects of sedation in 142 patients undergoing gastro-intestinal endoscopy was performed. Four regimens were studied (neurolept analgesia with and without topical anaesthesia, and anticholinergic and topical anaesthesia, with and without diazepam). Droperidol and fentanyl without topical anaesthesia yielded the best results as far as tolerance and side-effects were concerned. It is suggested that this form of neurolept analgesia be used for gastro-intestinal endoscopy.
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PMID:The use of neurolept analgesia for gastro-intestinal endoscopy. 34 84

Total I.V. anesthesia was given to 20 patients using an Etomidate continuous infusion to maintain sleep, combined to Fentanyl analgesia, Droperidol, Pancuronium for muscular relaxation and artificial ventilation with an oxygen-air mixture. All these patients were carefully observed during and for several hours after the anesthesia and the results noted. With the Fentanyl dosages used in this technique, peroperative analgesia was frequently insufficient. More Fentanyl would probably be needed with the inherent dangers of prolonged postoperative depression.
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PMID:Total I.V. anesthesia using a continuous etomidate infusion. 54 55

Droperidol and fentanyl have been used with diazepam in 250 peroral endoscopies because of dissatisfaction with standard methods of sedation. Excellant analgesia has been achieved and complications have been negligible. The technique does not require the presence of an anaesthetist.
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PMID:Neuroleptanalgesia in upper alimentary endoscopy. 97 5

In volunteer human subjects not undergoing surgical operations and breathing spontaneously, the cardiovascular effects of Innovar and of its components, fentanyl and droperidol, were determined when the drugs were administered in minimal amounts necessary to reach an analgesic endpoint. This amount was fentanyl 5 mcg./kg. body weight combined with droperidol 0.22 mg./kg. Innovar, or its components when administered separately, produced minimal cardiovascular changes of consequence during the time of maximum analgesia (about 15 minutes). With the passage of time after administration of a single dose of Innovar, there were some changes in cardiac output, heart rate, and stroke volume, probably representing normal changes of sedated sleep. None of the changes, acute or delayed, was clinically significant. Analgesia could be achieved only when fentanyl was combined with droperidol; and although a certain amount of respiratory depression resulted from the combined drugs, the authors concluded that the observed cardiovascular changes probably represented primary drug effects.
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PMID:Cardiovascular effects of minimal analgesic quantities of Innovar, fentanyl, and droperidol in man. 116 51

Innovar, administered intramuscularly 45 minutes preoperatively, provides excellent operative sedation, analgesia, and patient cooperation. Postoperative complications are minimized, and the quantity of postoperative analgesics and antiemetics is drastically reduced when Innovar is used as a preoperative medication.
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PMID:Innovar as a preoperative medication. 118 30

The realization that many intensive care patients develop psychoreactive problems ranging from confusion to depression to frank mutism led us to include Dehydrobenzperidol (DHB) in our analgesia and sedation scheme. The early prophylactic administration of this drug was found to be particularly effective in the prevention of delirium following an alcohol and/or drug overdose.
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PMID:[Psychopharmacologic aspects in intensive care medicine]. 181 35

Since 1984 the peritoneovenous shunt has been installed in 33 patients because of resistant ascites. The aim of this study was to find the optimal type of anesthesia in our conditions on our own clinical-patient material. All patients were classified by the ASA, Goldman, Child and Child-Puigh score. The patient, surgeon and anesthesiologist were polled about the quality of anesthesia, and all observed complications were followed, like after different premedications as well as in the course and after different types of neuroleptic anesthesia. General neuroleptic anesthesia was applied in 23 patients (69.7%), one was operated on in ketamine anesthesia (3.0%) and 9 (27.3%) in local anesthesia with 2% Xylocaine. After premedication with Thalamonal in all patients there came to a fall in arterial pressure for more than 20% of initial values and the feeling of uneasiness and fear was present. All patients with local anesthesia absolutely needed additional application of sedation or analgesia, especially during the formation of the subcutaneous tunnel, and neither patient nor surgeon were satisfied with the achieved comfort. During the course of neuroleptic anesthesia with Thalamonal hypotension developed, in 17/20 patients an in 2/20 the presence of prolonged apnea demanded additional artificial ventilation. In the patient operated on in ketamine anesthesia, an acute psychotic reaction developed, followed by visual and acustic hallucinations without signs of metabolic encephalopathy. On the basis of our own experience, we conclude that general neuroleptic anesthesia with the use of Flormidal as an anesthetic and Fentanil as an analgetic, is the method of choice, and that local anesthesia can be recommended only on one operative site (except the subcutaneous tunnel).
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PMID:[Anesthesia in peritoneovenous shunt placement]. 209 43

The paper reports 174 cases of brain operations in temporo-fronto-occipital region by using the regime of combined acupuncture and medication. The patients comprised of 122 males and 52 females. The acupoints consisted of ear needling and body needling. Adjuvant drugs used were half-dosage Innovar and 0.1% lidocaine for scalp infiltration. According to the documented two-grade scaling criteria, 97.1% patients belonged to grade I. No obvious discrepancy existed between ear needling group and body needling one. Three controlled groups are presented for comparison: 1) 0.1% lidocaine alone; 2) acupuncture plus normal saline; 3) acupuncture plus 0.1% lidocaine. The resultant P value was less than 0.005, with remarkable statistical significance. It is revealed that 0.1% lidocaine per se cannot achieve satisfactory analgesia, whereas the efficacy of acupuncture can be greatly enhanced by the combination of 0.1% lidocaine and acupuncture. This method is proved as an effectual means to offset the incomplete analgesia of acupuncture, especially for those requiring intraoperative demonstration of surgical effects, to avoid impairment to functional areas of cerebral cortex, which are undoubtedly superior to general anesthesia.
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PMID:[Application of acupuncture anesthesia during craniocerebral operation in temporo-fronto-occipital region]. 212 69

Domperidone 20 mg, droperidol 2.5 mg, metoclopramide 10 mg and placebo (saline) were given i.v. 10 min before the end of anaesthesia, to 200 women undergoing major gynaecological surgery, and the incidence of postoperative nausea and vomiting following a standard anaesthetic technique was assessed. Droperidol was significantly more effective than domperidone, metoclopramide or placebo in reducing emetic sequelae. There were no significant differences between the groups in the incidence of extrapyramidal effects and postoperative sedation. Patients given droperidol required less postoperative analgesia than those given domperidone or metoclopramide. It was concluded that, of the drugs studied, droperidol alone was effective in protecting against nausea and vomiting after major gynaecological surgery.
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PMID:Comparison of the use of domperidone, droperidol and metoclopramide in the prevention of nausea and vomiting following major gynaecological surgery. 294 64

The use of alfentanil was studied in 49 patients undergoing surgery with a duration of at least 90 minutes. Induction was performed with droperidol (Dehydrobenzperidol) and etomidate (Hypnomidate), maintenance with nitrous oxide/oxygen 2:1 and alfentanil. Alfentanil was administered as an initial bolus of 2-3 mg depending on the body weight of the patient, immediately followed by a continuous infusion of 0.75 microgram/kg/min. In case a stressful or painful event in surgery caused inadequate analgesia, additional increments of 1 mg of alfentanil were administered. Anesthesia was considered to be good in 90% of the patients. The number of additional increments needed did not increase as the anesthetic procedure progressed in time. In virtually all patients postoperative recovery was fast and not related to the number of increments. It is concluded that alfentanil infusion for longer procedures in combination with nitrous oxide/oxygen provided a good and easy method for maintaining a satisfactory level of analgesia.
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PMID:The use of alfentanil (Rapifen) by infusion for surgical procedures of long duration. 310 21


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