Gene/Protein
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Gene/Protein
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Target Concepts:
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Query: UMLS:C0344307 (
analgesia
)
28,200
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Volatile anesthetics produce safe, reversible unconsciousness, amnesia and
analgesia
via hyperpolarization of mammalian neurons. In molluscan pacemaker neurons, they activate an inhibitory synaptic K+ current (IKAn), proposed to be important in general anesthesia. Here we show that
TASK
and TREK-1, two recently cloned mammalian two-P-domain K+ channels similar to IKAn in biophysical properties, are activated by volatile general anesthetics. Chloroform, diethyl ether, halothane and isoflurane activated TREK-1, whereas only halothane and isoflurane activated
TASK
. Carboxy (C)-terminal regions were critical for anesthetic activation in both channels. Thus both TREK-1 and
TASK
are possibly important target sites for these agents.
...
PMID:Inhalational anesthetics activate two-pore-domain background K+ channels. 1032 Dec 45
