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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Study of the dynamics of changes of evoked potential (EP) amplitude in electrodental and electrocutaneous stimulation (EDS and ECS, respectively) as an index of the perceptual component of the nociceptive reaction showed that 0.2 mg/kg and 0.5 mg/kg doses of naloxone produce both a hyper- and an analgesic effect in rabbits. The effect of naloxone depended on the individual properties of the rabbits, while its degree was determined by the localization of the nociceptive stimulus. The animals' individual properties were manifested by the presence or absence of an analgesic effect of auricular electrostimulation--acupuncture-sensitive (AS) or acupuncture-resistant (AR) rabbits. Naloxone injection caused a dose-dependent hyperalgesic effect in AS animals and an analgesic effect in AR rabbits in EDS. Similar effects were recorded in ECS, but their degree differed: hyperalgesia in AS rabbits was demonstrated more clearly than analgesia in AR animals.
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PMID:[Nociceptive sensitivity of rabbits in varying localization of pain stimuli and naloxone administration]. 130 37

The effects of single and repeated maximal electroconvulsive shock (ECS, 150 mA, 50 Hz, 0.5 s) on the immunoreactive (ir-) dynorphin and beta-endorphin level in the rat brain, spinal cord and pituitary were studied. A single ECS induced a transient decrease in the hypothalamic ir-dynorphin, but did not influence the peptide content in the spinal cord, hippocampus and neurointermediate lobe of the pituitary. In contrast, the single ECS only slightly decreased the ir-beta-endorphin level in the hypothalamus, but caused a considerable fall in the peptide content in both lobes of the pituitary. A repeated ECS (every day for 9 days and 3 times a week for 3 weeks) markedly increased the ir-dynorphin content in the hypothalamus by 28 and 56%, respectively. Irrespective of the paradigm used, the repeated ECS strongly influenced spinal dynorphin neurons. At the beginning of our experiment (ECS applied 3 times) a fall in the peptide levels could be observed, but a longer treatment (ECS applied 9 times) led to its enhancement. The repeated ECS also induced a gradual decrease in the hippocampal ir-dynorphin level, followed by a long-term, rebound increase. In contrast to those numerous changes evoked in the dynorphin system, the repeated ECS did not evoke any changes in the hypothalamic and pituitary ir-beta-endorphin levels. As shown in the behavioral experiment, an acute ECS treatment resulted in a moderate increase in the pain threshold, measured by tail-flick and hot-plate tests. A prolonged ECS administration (3, 6 and 9 times) markedly enhanced the ECS-induced analgesia and catalepsy.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Single and repeated electroconvulsive shock differentially affects the prodynorphin and pro-opiomelanocortin system in the rat. 295 Sep 68