Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

To validate a laser-based method to measure thermal nociception in dairy cows (e.g., for the use in studies on stress-induced analgesia), we performed three experiments to observe the behavioral responses to a computer-controlled CO2 laser beam applied to the skin on the caudal aspect of the metatarsus. In Exp. 1, effects of power output (0, 1.3, 1.8, 2.2, 2.4 and 2.6 W) on nociceptive responses were examined using 18 dairy cows kept and tested in tie stalls. Increasing the power output affected the latencies to respond (decreasing latencies, P < or = 0.01), types of response (less nonresponding and more kicking, P < 0.0001), and behavior during (increasing frequency of tail flicking, P = 0.003) and between single laser exposures (increasing frequency of kicking, P = 0.02). Therefore, behavioral responses to a laser stimulus seem to be a valid measure of nociception in dairy cows. Repeatability within 15 min was investigated in Exp. 2 using n = 36 dairy cows kept and tested in tie stalls and a power output of 1.8 W. The variables' latency to move the exposed leg and frequency of tail flicking during laser exposure showed the highest level of repeatability (0.50 and 0.38, respectively). However, retesting at t = 15 min led to increased responses in terms of shorter latencies to respond (P < 0.05), increased kicking (P = 0.05), and tail flicking (P = 0.02), which probably can be explained by sensitization. Effects of power output (1.0 vs. 1.8 W) and skin condition (naked vs. intact) were examined in Exp. 3 on 11 group-housed dairy cows, tested just outside their home pen. Increasing the power output and shaving off hair led to increased responses as seen by shorter latencies to respond (P < 0.0001), less nonresponding (P < 0.0001), and increased kicking (P = 0.0003), as well as reduced intra- and interindividual variability (P < or = 0.04). In conclusion, the results of these experiments suggest that behavioral responses to laser stimulation are a valid and reliable measure of nociception in dairy cows, especially when applied on naked skin, both in the home environment and just outside a group pen. The fact that repeated testing in itself at t = 15 min led to increased responses means that the test will be a conservative measure of stress-induced analgesia.
 ...
PMID:A laser-based method to measure thermal nociception in dairy cows: short-term repeatability and effects of power output and skin condition. 1272 84

Dihydrocodeine (DHC) is a semi-synthetic analogue of codeine which was formed by the hydrogenation of the double tie in the main chain of the codeine molecule. DHC is used as an analgesic, antitussive and antidiarrhoeal agent; it is also used for the treatment of opioid addiction. Limited data is available on the relative potency of DHC to other opioids. The analgesic effect of DHC is probably twice as potent as codeine for the parenteral and slightly stronger for an oral route. DHC possesses approximately 1/6(th) of the morphine analgesic effect when drugs are administered orally. In this article pharmacokinetics, pharmacodynamics, dosing guidelines, adverse effects and clinical studies of DHC in pain management are shown with focus on cancer pain. The impact of CYP2D6 activity on DHC analgesia was discussed and a proposal of calculation equianalgesic doses of DHC to other opioids was put forward.
 ...
PMID:Dihydrocodeine as an opioid analgesic for the treatment of moderate to severe chronic pain. 2054 Jun 93

Mouse models are a valuable tool for studying acute injury and chronic remodeling of the myocardium in vivo. With the advent of genetic modifications to the whole organism or the myocardium and an array of biological and/or synthetic materials, there is great potential for any combination of these to assuage the extent of acute ischemic injury and impede the onset of heart failure pursuant to myocardial remodeling. Here we present the methods and materials used to reliably perform this microsurgery and the modifications involved for temporary (with reperfusion) or permanent coronary artery occlusion studies as well as intramyocardial injections. The effects on the heart that can be seen during the procedure and at the termination of the experiment in addition to histological evaluation will verify efficacy. Briefly, surgical preparation involves anesthetizing the mice, removing the fur on the chest, and then disinfecting the surgical area. Intratracheal intubation is achieved by transesophageal illumination using a fiber optic light. The tubing is then connected to a ventilator. An incision made on the chest exposes the pectoral muscles which will be cut to view the ribs. For ischemia/reperfusion studies, a 1 cm piece of PE tubing placed over the heart is used to tie the ligature to so that occlusion/reperfusion can be customized. For intramyocardial injections, a Hamilton syringe with sterile 30 gauge beveled needle is used. When the myocardial manipulations are complete, the rib cage, the pectoral muscles, and the skin are closed sequentially. Line block analgesia is effected by 0.25% marcaine in sterile saline which is applied to muscle layer prior to closure of the skin. The mice are given a subcutaneous injection of saline and placed in a warming chamber until they are sternally recumbent. They are then returned to the vivarium and housed under standard conditions until the time of tissue collection. At the time of sacrifice, the mice are anesthetized, the heart is arrested in diastole with KCl or BDM, rinsed with saline, and immersed in fixative. Subsequently, routine procedures for processing, embedding, sectioning, and histological staining are performed. Nonsurgical intubation of a mouse and the microsurgical manipulations described make this a technically challenging model to learn and achieve reproducibility. These procedures, combined with the difficulty in performing consistent manipulations of the ligature for timed occlusion(s) and reperfusion or intramyocardial injections, can also affect the survival rate so optimization and consistency are critical.
 ...
PMID:Coronary artery ligation and intramyocardial injection in a murine model of infarction. 2167 49

Ankyloglossia (or tongue-tie) is a relatively uncommon congenital anomaly defined by an abnormally short lingual frenulum. Associations between tongue-tie and breastfeeding problems in infants have been inconsistent, and are a longstanding source of controversy in the medical community. Definitions of ankyloglossia vary, and management suggestions are not based on randomized controlled trials. Surgical correction involves cutting the lingual frenulum (frenotomy). Based on current available evidence, frenotomy cannot be recommended. If, however, the association between significant tongue-tie and major breastfeeding problems is clearly identified and surgical intervention is deemed necessary, frenotomy should be performed by a clinician experienced with the procedure and with appropriate analgesia. More definitive recommendations regarding the management of tongue-tie in infants await appropriately designed trials.
 ...
PMID:Ankyloglossia and breastfeeding. 2246 26

Dihydrocodeine (DHC) is a semi-synthetic analogue of codeine, which was formed by the hydrogenation of the double tie in the main chain of the codeine molecule - instead of a double bond between carbons 7 and 8 DHC possesses a single bond. DHC is used as an analgesic and antitussive agent and for the management of dyspnea and opioid addiction. Limited data is available on the potency of DHC to other opioids. The analgesic effect of DHC is similar to codeine and approximately twice as potent as tramadol for an oral route. In contrast to codeine and tramadol, DHC analgesia seem to be irrespective of CYP2D6 activity due to parent compound analgesic effects, multiple metabolic pathways and limited role of dihydromorphine in DHC analgesia. As the drug is commonly available appropriate titration and dosing and knowledge of its metabolism and possible adverse effects are important for safe prescription of DHC.
...
PMID:Dihydrocodeine: safety concerns. 2647 86