Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Enflurane was given as the principal inhalatory agent in general anaesthesia in 75 patients aged from 17 to 55 years for gynaecological operations. Anaesthesia was conducted with muscle relaxation administering the drug in concentration of 0.2-1% vol. (mean maintenance concentration 0.6%). No cardiovascular, hepatic and renal disturbances were observed. The serum glucose level increased by a mean value of 64.8% during enflurance anaesthesia, however, it did not cross the renal threshold. Enflurane failed to ensure postoperative analgesia. The drug may be used as a valuable supplement to the presently used anaesthetic agents.
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PMID:Enflurane in anaesthesiological practice. 102 71

Anesthesiological considerations are discussed on the basis of the limited literature available and our own experience with more than 2000 ESWL treatments. Guidelines concerning anesthesia technique and ESWL treatment of renal and ureteral stones are outlined and compared to our own results and those in the literature. The following techniques are discussed: intubation anesthesia with halogenated carbohydrogens (Fluothane, Ethrane), intubation anesthesia with Fluothane/Ethrane plus opiates, neuroleptic anesthesia, catheter peridural anesthesia (lumbar/thoracic), opiate analgesia and high frequency jet ventilation.
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PMID:[Anesthesiologic aspects of extracorporeal shockwave lithotripsy (ESWL)]. 288 Apr 20

The effects of several anaesthetics on spinal cord nociceptive neural mechanisms and their interactions with the opiate antagonist, naloxone, were studied in acute, spinal cord transected cats. Intra-arterial injection of bradykinin was used as the noxious test stimulus. Spontaneous activity and the neural response induced by bradykinin were recorded by the multi-unit activity technique in the lateral funiculus of the spinal cord. Naloxone, 0.1 or 2.0 mg/kg i.v. had little effect on the bradykinin-induced response, but enhanced the spontaneous firing of the lateral funiculus significantly. Fentanyl, 30 micrograms/kg i.v., depressed both the bradykinin-induced response and spontaneous firing. These effects of fentanyl were antagonized completely by naloxone, 0.1 mg/kg i.v. Nitrous oxide, thiamylal, halothane and ether depressed the bradykinin-induced response considerably, but it was not antagonized by naloxone, 0.1-2.0 mg/kg i.v. Enflurane had little effect on the bradykinin-induced response. The effects of these anesthetics on spontaneous firing were divergent: nitrous oxide enhanced it while other drugs depressed it, to various degrees. All these data suggest that the neural and/or neurochemical mechanisms of anesthetic-induced analgesia differ from mechanisms related to opioids.
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PMID:Naloxone does not antagonize the anesthetic-induced depression of nociceptor-driven spinal cord response in spinal cats. 628 89