Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective study of 101 patients with cellulitis of the head and neck and extremities showed that cellulitis, predominantly a disease of males, occurred at all ages; the lower extremities were affected more frequently in the elderly, whereas upper extremity involvement prevailed in young adults. A clinical prodrome, most often including chills, was less common than is widely believed. Redness, heat, swelling, and tenderness were consistently present, and lymphangitis and lymphadenitis were less frequent. Fever was generally mild, and WBC counts were modestly elevated, if at all. Because needle aspirates and blood cultures were rarely helpful, delineation of specific cause was difficult. Therapy included rest, elevation, moist heat, analgesia, antibiotics (usually penicillinase-resistant penicillin or penicillin itself), and incision and drainage when indicated. Most patients improved rapidly. Prolonged course and complications were unusual and there were no deaths.
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PMID:Cellulitis: analysis of 101 cases and review of the literature. 697 17

The decision to prescribe antibiotics post-tonsillectomy still remains controversial. However, recent changing trends in the tonsillar tissue microflora have been widely reported, with Haemophilus influenzae, Staphylococcus aureus and anaerobic organisms all being implicated. All of the above are beta-lactamase producers and thus render lactamase prone antibiotics inactive. We compared two groups of children, one on Amoxycillin and clavulanic acid (a lactamase stable antibiotic with anaerobic cover) for 1 week post tonsillectomy--Group A (N = 44), and another group on no treatment--Group B (N = 34). We compared tonsillar core, surface and postoperative tonsillar fossae bacteriological profiles in the two groups. The tonsil core pathogens included H. influenzae (64%) of which 9.5% were beta-lactamase producers, Streptococcus viridans (55.9%), S. aureus (37%) of which 86% were beta-lactamase producers, and anaerobes which were found in 25% of samples. We found that there was considerably less morbidity in those children receiving postoperative antibiotics compared to those who did not, as judged by the amount of analgesia consumed (p = 0.379), time to resumption of normal diet (p = 0.0072) and pain analogue scores (p = 0.0006). We feel that treating children who have undergone tonsillectomy with amoxycillin and clavulanic acid significantly reduces postoperative morbidity.
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PMID:Antibiotic prophylaxis post-tonsillectomy: is it of benefit? 1059 82