Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In volunteer human subjects not undergoing surgical operations and breathing spontaneously, the cardiovascular effects of Innovar and of its components, fentanyl and droperidol, were determined when the drugs were administered in minimal amounts necessary to reach an analgesic endpoint. This amount was fentanyl 5 mcg./kg. body weight combined with droperidol 0.22 mg./kg. Innovar, or its components when administered separately, produced minimal cardiovascular changes of consequence during the time of maximum analgesia (about 15 minutes). With the passage of time after administration of a single dose of Innovar, there were some changes in cardiac output, heart rate, and stroke volume, probably representing normal changes of sedated sleep. None of the changes, acute or delayed, was clinically significant. Analgesia could be achieved only when fentanyl was combined with droperidol; and although a certain amount of respiratory depression resulted from the combined drugs, the authors concluded that the observed cardiovascular changes probably represented primary drug effects.
 ...
PMID:Cardiovascular effects of minimal analgesic quantities of Innovar, fentanyl, and droperidol in man. 116 51

Innovar, administered intramuscularly 45 minutes preoperatively, provides excellent operative sedation, analgesia, and patient cooperation. Postoperative complications are minimized, and the quantity of postoperative analgesics and antiemetics is drastically reduced when Innovar is used as a preoperative medication.
 ...
PMID:Innovar as a preoperative medication. 118 30

The paper reports 174 cases of brain operations in temporo-fronto-occipital region by using the regime of combined acupuncture and medication. The patients comprised of 122 males and 52 females. The acupoints consisted of ear needling and body needling. Adjuvant drugs used were half-dosage Innovar and 0.1% lidocaine for scalp infiltration. According to the documented two-grade scaling criteria, 97.1% patients belonged to grade I. No obvious discrepancy existed between ear needling group and body needling one. Three controlled groups are presented for comparison: 1) 0.1% lidocaine alone; 2) acupuncture plus normal saline; 3) acupuncture plus 0.1% lidocaine. The resultant P value was less than 0.005, with remarkable statistical significance. It is revealed that 0.1% lidocaine per se cannot achieve satisfactory analgesia, whereas the efficacy of acupuncture can be greatly enhanced by the combination of 0.1% lidocaine and acupuncture. This method is proved as an effectual means to offset the incomplete analgesia of acupuncture, especially for those requiring intraoperative demonstration of surgical effects, to avoid impairment to functional areas of cerebral cortex, which are undoubtedly superior to general anesthesia.
 ...
PMID:[Application of acupuncture anesthesia during craniocerebral operation in temporo-fronto-occipital region]. 212 69

To evaluate the insulin response and the rates of disappearance of glucose from plasma during high spinal analgesia and various types of general anaesthesia, a series of intravenous glucose tolerance tests was performed in six dogs. Plasma glucose and insulin levels were measured during the intravenous glucose tolerance tests. Insulinogenic indices were calculated. The values obtained during anaesthesia were compared to those obtained during an unanaesthetized state. The insulinogenic index was increased significantly during high spinal analgesia and thiopentone infusion. Halothane and enflurane anaesthesia decreased the insulinogenic index significantly while Innovar-nitrous oxide also decreased it, but not significantly. These findings suggest that insulin secretion in response to hyperglycaemia is stimulated by spinal analgesia and thiopentone anaesthesia, depressed by halothane and enflurane anaesthesia and unchanged during neuroleptanesthesia. A diuresis was observed in the thiopentone anaesthetic and spinal analgesic groups as compared to the other general anaesthetic groups. Urinary losses of insulin and glucose paralleled urinary output; yet the greatest mean urinary loss of glucose did not exceed 4.5 per cent of the load of glucose administered. Accordingly, 95 per cent of the administered glucose remained within the body, presumably available for utilization.
 ...
PMID:Intravenous glucose tolerance test during anaesthesia in dogs: insulin response and glucose clearance. 702 Aug 89

Medetomidine and fentanyl-droperidol (Innovar-vet) were assessed over a three hour period in 80 healthy dogs. Following physical examination, electrocardiogram (ECG), arterial blood sample analysis, and dynamometer pressure threshold (analgesia score), the dogs were randomly assigned to one of four treatments: Miv--medetomidine (750 micrograms/M2) administered intravenously (IV), Mim--medetomidine (1000 micrograms/M2) administered intramuscularly (IM), Iiv--Innovar-vet IV (0.05 mL/kg) or Iim--Innovar-vet IM (0.1 mL/kg). All assessments were carried out by a single individual unaware of the treatment used. Objective assessments included temperature, heart and respiratory rates, analgesia score, arterial blood gases, acid-base and lactate levels. Subjective evaluation included degree of sedation, response to various clinical procedures, noise responsiveness, posture, and the incidence of side effects. Onset and duration of effect were also recorded. The ECG strips were assessed for arrhythmias. Data was analyzed using a 3-way analysis of variance for continuous variables and a Chi-square analysis of frequencies. A p value < or = 0.05 was considered significant. Medetomidine-treated animals had a decreased respiratory rate, longer duration of analgesic effect, increased incidence of bradycardia, vomiting and twitching, were less noise responsive and shivered less throughout the study. An increased incidence of second degree heart block with Miv (15 min), a delayed onset and recovery with Mim and increased lactate levels following Iiv (15 min) were observed. No differences were found in other measurements and good to excellent chemical restraint was produced with all treatments in 65% or more cases.
 ...
PMID:Comparison of medetomidine and fentanyl-droperidol in dogs: sedation, analgesia, arterial blood gases and lactate levels. 849 Aug 14