Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A report is presented on 114 terminations of pregnancy during the second and third trimesters of pregnancy with a new (PGE) prostaglandin E2 derivative Sulprostone. In 84 cases, legal therapeutic abortions were induced. In 30 women an abnormal pregnancy was terminated. Sulprostone is a PG with selective activity in the uterus. It can be administered parenterally or locally. 48 women received intravenous sulprostone, 35 patients had extraamniotic injections and 31 patients had extraamniotic injections following an intramuscular injection for priming of the cervix the night before. In 103 women, the pregnancy was terminated within the first 24 hours after the administration of sulprostone (90.3%). 8 patients (7.0%) had a cervical dilatation over 2 cm. In 3 women no effect was noted. In 1 patient, the PG application was stopped because of severe vomiting. The mean administration abortion interval was 12 hours with intravenous infusion of sulprostone, 12 hours and 54 minutes following extraamniotic application and 10 hours and 30 minutes with extraamniotic administration following intramuscular priming. In 5 patients the abortion was completed after the priming administration. More than 90% of the patients required analgesia. 32.4% displayed side effects, all of mild character. The results and the methods are described and compared to other methods. (Author's modified)
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PMID:[Induction of abortion during the second and third trimester of pregnancy with sulprostone (author's transl)]. 721 68

A case of chest pain in a 31-year-old woman after vaginal delivery with epidural analgesia during sulprostone administration is described. Chest pain occurred shortly after sulprostone was started and disappeared when sulprostone was stopped. Ischaemia related data were negative. Angiographically coronary arteries were normal. Coronary artery spasm aetiology was retained. Sulprostone pharmacology is summarized. Coronary artery effects are compared with literature reports. Recommendations before sulprostone use are underlined.
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PMID:[Chest pain and sulprostone during postpartum hemorrhage]. 1247 87