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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In this study, 40 postarthroscopy patients were treated with either diflunisal or acetaminophen with codeine to control postoperative pain. In comparing these two drugs, better known as Dolobid and Tylenol #3, the results were comparable, though acetaminophen with codeine seemed to have a more rapid onset of action. Diflunisal provided better continuity of analgesia and less frequent dosing.
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PMID:Analgesia following arthroscopic surgery: comparison of diflunisal and acetaminophen with codeine. 373 61

The analgesic efficacy of single 500- and 1,000-mg doses of diflunisal (Dolobid), a new nonsteroidal anti-inflammatory analgesic, was compared in a double-blind study with that of acetaminophen, 600 mg, the combination of acetaminophen, 600 mg, with codeine phosphate, 60 mg, and placebo in 159 oral surgery outpatients. Using a self-rating record, patients rated their pain and its relief hourly for 12 hours after medication. Both doses of diflunisal were significantly more effective than acetaminophen alone and produced peak analgesia comparable to that of the acetaminophen-codeine combination. Diflunisal proved to have an unusually long duration of analgesic action. Acetaminophen and the combination were significantly superior to placebo through hours 2 and 5, respectively; both doses of diflunisal were significantly superior through the end of the 12-hour observation period. None of the active treatments produced more side effects than the placebo.
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PMID:Diflunisal. A new oral analgesic with an unusually long duration of action. 675 Jan 71