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Query: UMLS:C0344307 (
analgesia
)
28,200
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of GABA-ergic compounds on morphine-induced
analgesia
was studied to reveal probable interaction of GABA and opiates. As an index for morphine effect the reaction of vocalization in response to electrical stimulation of the rat tail was used. It was shown that thiosemicarbazide, the inhibitor of glutamate decarboxylase and bicuculline, GABA-ergic receptor blocking agent, which were proposed to be joined in a group of GABA-negative compounds, reduce and shorten the effect of morphine.
Depakine
, the inhibitor of alpha-ketoglutarate-GABA-transaminase, as well as GABA itself administered in high doses (GABA-positive actions) make morphine
analgesia
more pronounced and longer. Probable causes of the described interrelationship between GABA and opiates are discussed.
...
PMID:[Effect of GABA-ergic substances on the analgesic effect of morphine in rats]. 38 Jun 85
