Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Spinal anaesthesia of 20 does undergoing laparotomies was accomplished with epidural injections of 2 per cent lignocaine at a dosage of 1 ml per 4.55 kg in 16 goats. Epidural injection resulted in paralysis lasting 198.5 minutes +/- 36.6 minutes. Subarachnlid injection resulted in paralysis lasting 180.8 minutes +/- 44.9 minutes. Xylazine was given intramuscularly at the dosage of 0.11 mg per kg after posterior paralysis was complete. These treatments resulted in effective analgesia for surgical intervention. Recovery was complete and uneventful in all goats. An additional 26 operations were performed using this treatment and results were equally satisfactory.
 ...
PMID:Spinal analgesia and sedation of goats with lignocaine and xylazine. 51 12

Fourteen patients with postoperative pain were allowed to self-administer preset doses of pethidine intravenously via a logic-controlled motor syringe. Plasma samples were collected during anaesthesia and the postoperative self-administration period, and the concentrations of pethidine and nor-pethidine were determined. Separate single-dose studies in eight patients yielded pharmacokinetic parameters which made possible computer simulations of continuous plasma concentration curves for the anaesthesia and postoperative self-administration period. The consumption of pethidine showed great interindividual variations with a mean consumption for the entire group of 26 mg per hour. The patients established steady-state plasma concentrations with far less than the maximum amount of pethidine allowed. The mean measured plasma concentration of pethidine which provided adequate analgesia was 738 +/- 149 ng/ml. Simulated and measured plasma concentrations were in close agreement. The individual mean drug consumption per hour during self-administration correlated closely with the individual elimination rate of pethidine. No serious side effects were observed. Thus, patient-controlled analgesic therapy offers an individualized analgesic supply to meet an analgesic demand which is governed by each patient's appreciation of pain.
 ...
PMID:Patient controlled analgesic therapy in the early postoperative period. 53 41

Chloroprocaine hydrochloride 2% and bupivacaine hydrochloride 0.375% in 10-ml doses of plain solutions were studied in a randomised blind manner as the agents for continuous lumbar extradural analgesia in labour. Twenty-four patients were assessed for the speed of onset, duration of action, degree of motor blockade, dermatomal spread, arterial hypotension, and the incidence of unblocked segments. Chloroprocaine showed a quicker onset time and a shorter duration of action than bupivacaine. Chloroprocaine exhibited more marked motor blockade and a lower incidence of unblocked segments. The dermatomal spread and effect on arterial pressure were similar in both groups.
Anaesthesia 1979 Oct
PMID:Extradural analgesia in labour. A comparison of 2-chloroprocaine hydrochloride and bupivacaine hydrochloride. 53 19

An obstetric patient had a subarachnoid block during attempted extradural analgesia for labour. The sensory block extended to T1 and was accompanied by hypotension. The analgesia lasted 3 hr. after which sensory and motor function recovered quickly. The local anaesthetic agent used was 2% 2-chloroprocaine.
Anaesthesia 1979 Oct
PMID:Subarachnoid injection during extradural analgesia for labour using 2-chloroprocaine. 53 24

Seven hundred and twenty-two patients who received epidural analgesia during labour were delivered by Caesarean section. The block was extended in 554 patients to provide analgesia for surgery. In twenty-one cases incomplete analgesia necessitated general anaesthesia. The main complications were maternal hypotension (15.9%) and vomiting (17.1%). Almost all patients expressed enthusiasm for the technique.
Anaesthesia
PMID:The extension of labour epidural analgesia for Caesarean section. 53 48

Total I.V. anesthesia was given to 20 patients using an Etomidate continuous infusion to maintain sleep, combined to Fentanyl analgesia, Droperidol, Pancuronium for muscular relaxation and artificial ventilation with an oxygen-air mixture. All these patients were carefully observed during and for several hours after the anesthesia and the results noted. With the Fentanyl dosages used in this technique, peroperative analgesia was frequently insufficient. More Fentanyl would probably be needed with the inherent dangers of prolonged postoperative depression.
 ...
PMID:Total I.V. anesthesia using a continuous etomidate infusion. 54 55

In 463 patients the total intravenous anesthesia technique was applied, for which sleep was induced with etomidate and analgesia was obtained with fentanyl. This technique, which prevents pollution of the air, appeared to be easily applicable and without major complications in either spontaneously breathing or ventilated patients.
 ...
PMID:Etomidate-fentanyl-air anesthesia. 54 65

As part of an investigation of the quality of the return to consciousness after anaesthesia, a comparison was made between recovery times in 60 patients divided into three groups, subjected to general anaesthesia and shallow maintenance with halothane, mixed short shallow neuro-analgesia, and short analgesia anaesthesia. Psycho-aptitudinal recovery was evaluated with three graphic tests. The results indicate that recovery times are much shorter for shallow neuro-analgesia, and particularly for analgesic anaesthesia by comparison with ordinary shallow techniques coupled with maintenance in O2 + N2O + Halothane.
 ...
PMID:[Study of recovery from anesthesia by means of graphic tests of writing and drawing]. 54 7

Controversy exists concerning the choice of anesthetic technic for elective cesarean section. Several maternal and newborn parameters were compared during general anesthesia (GA) and lumbar epidural analgesia (LEA). High inspired maternal O2 levels were achieved with both technics. Vigorous, well-oxygenated infants with good umbilical-cord acid-base values were delivered during both GA and LEA. Umbilical artery and vein pH were better with GA, but 1-minute Apgar-minus-color scores were higher and time to sustained respiration was shorter with LEA. On the basis of this study, neither technic can be vigorously recommended over the other from the standpoint of the newborn's condition.
 ...
PMID:A comparison of general anesthesia and lumbar epidural analgesia for elective cesarean section. 55 20

During recovery from spinal and epidural block, the progressive reduction of digital blood flow is regarded as evidence of sympathetic recovery of the extremity. This was demostrated by the decreasing amplitude of a digital pulse-wave (photoelectric plethysmographic) recording. As the level of analgesia regressed to T8-11 following spinal or epidural block, the toe pulse-wave amplitudes began to decrease. In the presence of good motor and sensory block in the lower extremity with low spinal or epidural anesthesia (level of analgesia T-11 or below), the clinical or photoeletric plethysmographic evidence of sympathetic denervation was minimal or absent. According to these findings, the authors postulate that some preganglionic sympathetic fibers which conduct sympathetic stimulation to the lower extremity originate at spinal cord segments T-10 or above.
 ...
PMID:Sympathetic recovery following lumbar epidural and spinal analgesia. 55 32


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>