Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 1960 direct laryngoscopy in combination with general anaesthesia with relaxation and intermittent positive negative pressure ventilation via a smallbore blocker tube was introduced. When, in 1965, microlaryngoscopy was developed it was exclusively performed with this technique. Since 1960, 44, 464 ear, nose or throat operations were carried out. 3,305 (7.4%) were endolaryngeal operations. 943 of them were performed in surface analgesia. 2,363 microlaryngoscopic operations were done under general anaesthesia. 22.5 per cent of the patients were women and 77.5 per cent were men. Their age varied between 6 weeks and 86 years. 2.4 per cent were children under 6 years of age and 33 per cent were aged over 60 years. The main advantages of this method over "open laryngeal surgery" are: 1. it provides a large measure of safety for the patient since even old and obese persons with a rigid rib cage can be adequately ventilated; the cuff prevents aspiration; there is no danger of the patient waking up during relaxation since he is being kept ventilated with a mixture of nitrous oxide-oxygen and halothane. Ventilation via the blocker tube begins immediately after intubation and not, as in open jet ventilation, after insertion of the laryngoscope. 2. The surgeon and his team are not exposed to the risk of infection since, in contrast to the "open larynx" methods, the closed system effectively prevents the escape of pathogenic micro-organisms.
 ...
PMID:[Development of anaesthetic technique for endolaryngeal surgery 1960--1976 (author's transl)]. 37 44

A new concept of anaesthesia in patients undergoing operations of the lumbar vertebral column is presented. Electrostimulation of four auricular acupuncture points is combined with controlled ventilation of nitrous-oxide oxygen mixture. This combination is comparable to similar anaesthesia procedures of other operative fields. In 30 patients the anaesthesia was performed as a "combined electrostimulationhypalgesia". In a control study of 30 similar patients a mixture of nitrous-oxide and oxygen only was used. For 120 min systolic and diastolic blood pressure as well as heart rate of both groups are measured and compared. The postoperative state as well as individual data from the patients are included in the investigation. The analgesia established by "combined electrostimulationhypalgesia" seems to be based essentially on the effect of nitrous-oxide as well as premedication, induction of anaesthesia, relaxation and kind of ventilation. Electrostimulation of auricular acupuncture points seems to induce stabilisation of the circulatory system. On account of our findings the relevance of electrostimulation in this method of anaesthesia must be judged very critically.
 ...
PMID:[Combined-electrostimulation-hypalgesia in surgery of the lumbar vertebral column. A tentative evaluation of this method (author's transl)]. 38 Mar 86

In two double-blind studies two hyperbaric 5% lidocaine solutions containing glucose in concentrations of 75 mg/ml and 50 mg/ml, respectively, were compared. The onset and total onset time, spread, intensity, duration of analgesia and motor block were studied. The spinal anaesthesia was given with the patient either sitting or in the lateral recumbent position. A tendency to a longer duration of anaesthesia near dermatomes Th X-L II and L IV-L V was noted in the group of patients in the sitting position and receiving lidocaine with a lower glucose concentration. Otherwise there were no differences between the two lidocaine solutions. The result shows that the glucose concentration can be reduced from 75 to 50 mg/ml in "heavy" lidocaine without any clinical disadvantage. This means a more isotonic solution in relation to the cerebrospinal fluid, resulting in milder osmotic effects on interspinal structures.
 ...
PMID:Clinical significance of specific gravity of spinal anaesthetic agents. Two double-blind studies with hyperbaric 5% lidocaine. 39 55

A comparison was made between the effects of two different anesthetics, alpha-D-gluco-chloralose and 1-1-phenylcyclohexyl piperidine hydrochloride (Sernylan), on cerebral blood flow (CBF), brain metabolism and cerebrovascular CO2 responsiveness in primates. The experiments were carried out on immobilized and artificially ventilated baboons. Anesthesia was induced either with 100/mg/kg chloralose (i.p.) or with 1 mg/kg Sernylan (i.m.). CBF in 8 different brain regions was measured by the intra-arterial 133Xe clearance technique. The CO2 responsiveness of the cerebrovascular bed was tested by a gas mixture containing 5% CO2. Chloralose depressed total as well as regional CBF compared to the effect of Sernylan. A significant shift occurred toward lower CBF values in the grey matter while white matter flow was identical in the two groups. Brain O2 consumption was significantly higher during Sernylan analgesia (3.35 +/- 0.34 ml/100 g/min) than during chloralose anesthesia (2.42 +/- 0.22 ml/100 g/min). There were no differences in glucose uptake, lactate and pyruvate production, or in arterial and cerebral venous blood gases in the two types of anesthesia. The cerebrovascular CO2 sensitivity of the Sernylan-treated baboons was higher than that of the chloralose-anesthetized animals, in both the grey and white matter.
 ...
PMID:Comparative effects of chloralose anesthesia and Sernylan analgesia on cerebral blood flow, CO2 responsiveness, and brain metabolism in the baboon. 40 48

Three hundred fifty-seven groin hernia repairs were performed under local anesthesia using a long-lasting local anesthetic agent. An ilioinguinal, iliohypogastric, and twelfth intercostal nerve block was carried out initially, followed by regional infiltration of the agent, using a technic first described by Ponka [8] with several modifications. This technic can be employed suffessfully in the majority of groin hernia repairs. It requires careful attention to detail in the administration of preoperative sedation and analgesia and the use of sharp dissection only and greater gentleness in the handling of tissue. We have observed a significant reduction in postoperative discomfort and the virtual elimination of urinary retention, urinary sepsis, atelectasis, and phlebitis in these cases. All patients are fully ambulatory, without assistance immediately after surgery and the majority are discharged the same day or the following morning. This results in a marked reduction in the total cost of repairing a groin hernia.
 ...
PMID:Change in the management of adult groin hernia. 41 25

The anaesthetic requirements for peripheral angiographies in geriatric or poor risk patients are temporary sedation, analgesia and sufficient immobilisation. Neither general anaesthesia using muscle relaxants and assisted ventilation nor regional methods warrant satisfactory results in all cases, especially if multiple arteriographies are to be performed at the same session. Therefore a few new anaesthetic techniques were studied, having combined benzodiazepines with ultrashort acting intravenous narcotics. Premedication with Pethidin 1mg/kg, the administration of Flunitrazepam 0,017 mg/kg with regard to sedative, analgesic and relaxant effects and Methohexital 0.67 mg/kg as anaesthetic given prior to injection of contrast medium would seem more useful than other techniques.
 ...
PMID:[Anaesthesia for peripheral angiographies (author's transl)]. 41 63

A study of 50 patients undergoing haemorrhoidectomy under general anaesthesia in Reading was undertaken. Half the patients received, in addition, a caudal anaesthetic given by the surgeon at the beginning of the operation with the patient in the lithotomy position. The rest of the patients had no form of local anaesthetic. The amount of analgesia needed, general comfort after the operation, and the number of days after surgery of the first bowel movement were recorded. The use of caudal anaesthesia resulted in a 79% reduction in the number of doses of papaveretum needed by the patients after the operation and a reduction by half in the period of postoperative constipation. Possible reasons for the latter finding are discussed. The possible risks of caudal anaesthesia are considered, but it is concluded that they are far outweighed by the benefits obtained.
 ...
PMID:Haemorrhoidectomy without tears. 42 Apr 95

In reviewing techniques for therapeutic local anaesthesia of pain spots, it appeared that the common denominator was puncture by the needle and not the anaesthetic employed. The present study examines short- and long-term effects of dry needling in the treatment of chronic myofascial pain. 241 patients and 312 pain sites were treated by needling. When the most painful spot was touched by the needle, immediate analgesia without hypesthesia was observed in 86.8% of cases. Permanent relief of tenderness in the needled structure was obtained for 92 structures; relief for several months in 58; for several weeks in 63; and for several days in 32 out of 288 pain sites followed up. The effectiveness of treatment was related to the intensity of pain produced at the trigger zone, and to the precision with which the site of maximal tenderness was located by the needle. The immediate analgesia produced by needling the pain spot has been called the "needle effect".
 ...
PMID:The needle effect in the relief of myofascial pain. 42 36

A case of pregnancy complicated by malignant hyperthermia susceptibility is reported. Serum CPK and electrolyte concentrations were measured during pregnancy and labour. Labour and delivery were managed successfully under epidural analgesia using plain bupivacaine 0.5%.
Anaesthesia 1979 Jan
PMID:Malignant hyperthermia susceptibility. Management during pregnancy and labour. 42 40

Fourteen patients with a variety of neoplasms not responsive to standard forms of therapy underwent whole body hyperthermia for a maximum 4 h at 41.8 degrees C. This was a phase-I cancer trial designed to develop whole body hyperthermia as an adjuvant to systemic chemotherapy. Intravenous analgesia was used to sedate patients, obviating the need for general endotracheal anesthesia. Hyperthermia was induced by means of a high-flow water perfusion suit. Cardiovascular performance was evaluated using a flow-directed pulmonary artery catheter. Patients developed a twofold mean increase in cardiac index without evidence of cardiac damage by ECG or creatine phosphokinase (CPK) isoenzymes. An acute fall in serum magnesium and phosphate and an acute rise in arterial pH, serum CPK values, and granulocyte count occurred in all patients. There were no clotting abnormalities. Toxicity included fatigue, diarrhea, nausea, and transient elevations in liver enzymes. Four patients were febrile for 36 h after initial defervescence. Peripheral neuropathy developed in four. These results show that with carefully monitored conditions whole body hyperthermia is feasible.
 ...
PMID:Whole body hyperthermia: a phase-I trial of a potential adjuvant to chemotherapy. 42 99


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>