Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0344307 (analgesia)
 28,200 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a preliminary open study of salsalate (3 g daily for 4 weeks) in 61 patients with rheumatoid arthritis or osteoarthrosis, it was found that although the drug produced satisfactory analgesia in 64% of patients, the incidence of side-effects was high (57% of patients): most were symptoms of salicylism and probably related to the high plasma salicylate levels achieved. In a second open study, 20 patients with osteoarthrosis were treated for 4 weeks with 250 mg diflunisal twice daily and then crossed over to salsalate (3 g daily) for a further 2 weeks. The results of subjective assessments of pain relief showed that both drugs produced satisfactory analgesia, and neither was associated with a significant level of gastro-intestinal bleeding. During the diflunisal treatment period there were no reports of salicylism, and plasma salicylate levels were very much lower than those measured after salsalate. The pain relieving effects of both drugs, assessed from patient preference for one or the other treatment, were unrelated to the plasma salicylate levels and it is suggested that plasma levels may have more relationship to the incidence of side-effects than with therapeutic effects.
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PMID:Relationship of plasma salicylate levels to pain relief with two different salicylates. 35 53

The incidence, time of onset and course of clinically manifest upper gastrointestinal bleeding was analysed in 265 polytraumatized patients with an average "injury severity score" (ISS) of 31.5. Under standardized intensive-care treatment - including appropriate artificial ventilation; maintenance of a stable circulation; complete parenteral and earliest possible enteral nutrition; low-dose heparinization; sedation and analgesia as required; and intragastric administration of antacids - only two patients (0.8%) had clinically manifest upper intestinal bleeding and then only preterminally in the course of incurable multi-organ involvement, the bleeding being a component of multiple organ failure. The focus of stress-ulcer prevention should lie in a decrease of factors precipitating multiple organ failure, as well as in the carefully selective use of general intensive-care measures. The need of general systemic prevention with H2-receptor blockers and (or) pirenzepine is questionable.
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PMID:[Significance of upper gastrointestinal hemorrhage in patients with multiple injuries]. 376 14